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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

SH3 domain containing ring finger 1

POSH, plenty of SH3s
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, AP-1, Rac1, Ubiquitin, MuSK
Papers using POSH antibodies
Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons
Greene Lloyd A. et al., In Cell research, 1997
... Anti-POSH antibody was from Abnova (Taiwan) ...
Papers on POSH
Family history and outcome of young patients with breast cancer in the UK (POSH study).
POSH Study Steering Group et al., Oxford, United Kingdom. In Br J Surg, Jul 2015
METHODS: Prospective Outcomes in Sporadic versus Hereditary breast cancer (POSH) is a large prospective cohort study of women aged less than 41 years with breast cancer diagnosed and treated in the UK using modern oncological management.
The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients.
Nevanlinna et al., Helsinki, Finland. In Oncotarget, May 2015
The top 39 SNPs from this stage were analyzed in three independent data sets: iCOGS (n=6720 chemotherapy-treated cases), SUCCESS-A (n=3596), and POSH (n=518).
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.
Sweeney et al., York, United Kingdom. In J Cell Biol, Apr 2015
We identify novel roles for endosomal JNK-scaffold POSH (Plenty-of-SH3s) and a JNK kinase kinase, TAK1, in regulating growth activation in Rab8 mutants.
An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ⩽40 years at breast cancer diagnosis.
Eccles et al., Cambridge, United Kingdom. In Br J Cancer, Apr 2015
This study was conducted to establish how well PREDICT performs in estimating survival in a large cohort of younger women recruited to the UK POSH study.
Cellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migration.
Kawauchi, Tokyo, Japan. In Front Cell Neurosci, 2014
The locomoting neurons exhibit unique features; a radial glial fiber-dependent migration requiring the endocytic recycling of N-cadherin and a neuron-specific migration mode with dilation/swelling formation that requires the actin and microtubule organization possibly regulated by cyclin-dependent kinase 5 (Cdk5), Dcx, p27(kip1), Rac1, and POSH.
Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study.
Eccles et al., London, United Kingdom. In Br J Cancer, 2014
METHODS: Women aged ≤ 40 years at breast cancer diagnosis were recruited to the POSH national cohort study (MREC: 00/06/69).
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.
Czene et al., Singapore, Singapore. In Nat Commun, 2013
We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events).
The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
Daniels et al., Columbia, United States. In Eur J Immunol, 2013
Here, we identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.
Prospective observational study of breast cancer treatment outcomes for UK women aged 18-40 years at diagnosis: the POSH study.
POSH Study Steering Group et al., Southampton, United Kingdom. In J Natl Cancer Inst, 2013
The Prospective Study of Outcomes in Sporadic and Hereditary Breast Cancer (POSH) was designed to investigate factors affecting prognosis in this patient group.
POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
Xu et al., Beijing, China. In Cell Rep, 2012
Here, we show that the Rac1-interacting scaffold protein POSH is essential for neuronal migration in vivo.
Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal.
Ruohola-Baker et al., Seattle, United States. In G3 (bethesda), 2012
Here we report that a group of mutations affecting various ubiquitin-conjugating enzymes cause significant GSCs loss, including Plenty of SH3s (POSH), Ubiquitin-conjugating enzyme 10 (UbcD10), and pineapple eye (pie).
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.
Greene et al., New York City, United States. In J Biol Chem, 2012
a model in which Sh3rf2 promotes proteasomal degradation of pro-apoptotic POSH in healthy cells and in which apoptotic stimuli lead to rapid loss of Sh3rf2 expression, and consequently to stabilization of POSH and JNK activation and cell death
Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.
Schwarze et al., Lexington, United States. In Mol Cancer, 2010
The data presented here define POSH and Siah2 as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy.
POSH promotes cell survival in Drosophila and in human RASF cells.
Aigaki et al., Hachiōji, Japan. In Febs Lett, 2010
POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts
POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila.
Xu et al., Beijing, China. In J Genet Genomics, 2010
evidence that the JNK pathway scaffold protein, POSH, is involved in TNF (Eiger) signaling in Drosophila
Regulation of the protein stability of POSH and MLK family.
Xu et al., Beijing, China. In Protein Cell, 2010
POSH's ability to induce apoptosis is correlated with its stability as well as its MLK binding ability.
Monte Carlo Sampling with Hierarchical Move Sets: POSH Monte Carlo.
Jacobson et al., San Francisco, United States. In J Chem Theory Comput, 2009
Since the forward and reverse transitions are different, we name the algorithm POSH (port out, starboard home) Monte Carlo.
Longevity determination genes in Drosophila melanogaster.
Matsuo et al., Hachiōji, Japan. In Mech Ageing Dev, 2002
Using a conditional misexpression system, we identified Drosophila POSH (DPOSH), a scaffold protein containing RING finger and four SH3 domains, whose ubiquitous overexpression in adult stage extends the longevity.
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