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Transmembrane protein 123

Porimin, Pro-oncosis receptor inducing membrane injury
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: 110-kDa, Orf, Apo, fibrillin-1
Papers on Porimin
Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123.
Tamaki et al., Tokyo, Japan. In J Biol Chem, 2010
Tmem123 may be used as a new maturation marker in DCs and that this molecule may be closely associated with the cell surface expression of CD40.
Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death.
Schlossman et al., Boston, United States. In Proc Natl Acad Sci U S A, 2001
Anti-Porimin (Pro-oncosis receptor inducing membrane injury) mAb mediates oncosis-like cell death in Jurkat cells.
A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis.
Schlossman et al., Boston, United States. In Proc Natl Acad Sci U S A, 1998
One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells.
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