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Paraoxonase 2

PON2, paraoxonase 2
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: paraoxonase, PON3, HAD, HDL, CAN
Papers on PON2
N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.
Li et al., Louisville, United States. In Oncotarget, Feb 2016
Furthermore, opposite to conventional chemotherapeutics, C12 requires paraoxonase 2 (PON2) to exert its cytotoxicity on tumor cells in vitro and its inhibitory effects on tumor growth in vivo.
Neurotoxicity of traffic-related air pollution.
Roqué et al., Seattle, United States. In Neurotoxicology, Dec 2015
In most cases, the effects of DE were more pronounced in male mice, possibly because of lower antioxidant abilities due to lower expression of paraoxonase 2.
Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.
Chung et al., Seoul, South Korea. In J Mol Neurosci, Nov 2015
The human paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3.
Glabridin, an isoflavan from licorice root, upregulates paraoxonase 2 expression under hyperglycemia and protects it from oxidation.
Tamir et al., Qiryat Ata, Israel. In Mol Nutr Food Res, Nov 2015
This study investigates the potential of glabridin to regulate paraoxonase 2 (PON2) levels, in vivo, and explores the glabridin protective effect on PON2 through tryptophan-fluorescence quenching and mass spectrometry.
The proteome of native adult Muller glial cells from murine retina.
Hauck et al., Regensburg, Germany. In Mol Cell Proteomics, Oct 2015
paraoxonase 2, peroxiredoxin 1, 4 and 6).
Paraoxonase activity as a marker of exposure to xenobiotics in tobacco smoke.
Socha et al., Wrocław, Poland. In Int J Toxicol, May 2015
The paraoxonase (PON) family is composed of 3 proteins (PON1, PON2, and PON3), each of which plays a crucial role in the body, displaying antioxidant, anti-inflammatory, and antiatherosclerotic properties.
Paraoxonase 2 Induces a Phenotypic Switch in Macrophage Polarization Favoring an M2 Anti-Inflammatory State.
Hayek et al., Haifa, Israel. In Int J Endocrinol, 2014
Paraoxonase 2 (PON2) is expressed in macrophages, and it was shown to protect against atherosclerosis.
Review: The role of paraoxonase in cardiovascular diseases.
Milnerowicz et al., Wrocław, Poland. In Ann Clin Lab Sci, 2014
Paraoxonase (PON) is a group of proteins present in three forms (PON1, PON2, PON3) encoded by genes PON1, PON2, and PON3.
Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets.
Pal et al., New Delhi, India. In Bmc Cancer, 2014
The hormone increased the transcription and/or expression of molecular intermediates (SURVIVIN, HIF-1α, PARP-1, Bcl-2, c-FLIP, KLK-10, XIAP, c-IAP-1) associated with chemo-resistance and increased levels of stress modulators (PON2, HO-1, HSP27 and NRF-2).
An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.
Manco et al., Napoli, Italy. In Plos One, 2014
The human paraoxonase 2 (PON2) has been described as a highly specific lactonase hydrolysing the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) and having secondary esterase but not phosphotriesterase activity, in contrast with the related enzymes PON1 and PON3.
Characterization of the paraoxonase system in follicular fluid of women subjected to an ovarian stimulation cycle.
Ruiz-Larrea et al., Spain. In Free Radic Biol Med, 2014
The objective of this work was a) to characterize the paraoxonase system in follicular fluid of women undergoing a controlled ovarian stimulation cycle, analysing the associated PON1, PON2, and PON3 activities, and b) to study the possible involvement of the PON system in follicular maturation.
Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Agundez et al., Madrid, Spain. In Curr Drug Metab, 2014
Polymorphisms related with activation or detoxification of drugs and xenobiotics, such as CYP1A1, CYP1A2, CYP19A1, CYP1B1, CYP2C9, CYP2C19, CYP2E1, CYP2D6, NAT2, GSTM1, GSTM3, GSTO1, GSTP1, PON1, PON2, ABCB1 and ADH genes have not been demonstrated convincingly a definitive association with the risk of developing PD.
Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review.
Joven et al., Reus, Spain. In Int J Mol Sci, 2013
Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism's antioxidant system; alterations in which are associated with diseases involving oxidative stress.
Inflammation, infection, cancer and all that…the role of paraoxonases.
Reddy et al., Los Angeles, United States. In Adv Exp Med Biol, 2013
The paraoxonase (PON) gene family consists of three members, PON1, PON2 and PON3.
Paraoxonase 2 acts as a quorum sensing-quenching factor in human keratinocytes.
Harder et al., In J Invest Dermatol, 2012
PON2 acts as a QS-quenching factor in keratinocytes and may have an important role in cutaneous defense against bacterial infections.
Association between paraoxonase 2 Ser311Cys polymorphism and ischemic stroke risk: a meta-analysis involving 5,008 subjects.
Li et al., Chongqing, China. In Mol Biol Rep, 2012
The aim of this study was to perform a meta-analysis to investigate a more authentic association between PON2 Ser311Cys polymorphism and ischemic stroke.
Predictive role of multilocus genetic polymorphisms in cardiovascular disease and inflammation-related genes on chronic kidney disease in Type 2 diabetes--an 8-year prospective cohort analysis of 1163 patients.
Chan et al., Hong Kong, Hong Kong. In Nephrol Dial Transplant, 2012
Single-nucleotide polymorphisms in PON2 is associated with chronic kidney disease in Type 2 diabetes.
Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians.
Juyal et al., New Delhi, India. In Pharmacogenet Genomics, 2011
The association of PON2, with Parkinson's disease among Indians may point toward an inherent population-specific genetic predisposition
Paraoxonase gene polymorphism and the risk for Alzheimer's disease in the polish population.
Slowik et al., Kraków, Poland. In Dement Geriatr Cogn Disord, 2010
the studied PON2 polymorphism is not associated with late-onset Alzheimer's disease
Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies.
Danesh et al., Cambridge, United Kingdom. In Lancet, 2004
METHODS: We conducted a meta-analysis of 43 studies of the Q192R, L55M, and T(-107)C polymorphisms in the paraoxonase PON1 gene and the S311C polymorphism in the PON2 gene (all of which are in moderately strong linkage disequilibrium with one another), involving a total of 11212 CHD cases and 12786 controls.
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