gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Patatin-like phospholipase domain containing 5

PNPLA5, GS2-Like
This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: PNPLA3, pigment epithelium-derived factor, apolipoprotein B, LDL receptor, PCSK9
Papers on PNPLA5
Recent developments in genome and exome-wide analyses of plasma lipids.
Rich et al., Charlottesville, United States. In Curr Opin Lipidol, Apr 2015
Exome sequencing promises to identify genes with protein-coding variants with a large impact on lipids, as shown for LDL-cholesterol levels associated with novel (PNPLA5) and known (LDLR, PCSK9, APOB) genes.
Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis.
Deretic et al., Albuquerque, United States. In Curr Biol, 2014
We carried out a screen for a potential link between triglyceride mobilization and autophagy and identified a neutral lipase, PNPLA5, as being required for efficient autophagy.
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
NHLBI Grand Opportunity Exome Sequencing Project et al., Chapel Hill, United States. In Am J Hum Genet, 2014
We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previously unidentified variants in PCSK9, LDLR and APOB, three known lipid-related genes.
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
Shukla et al., Marshfield, United States. In Front Genet, 2013
The nearby genes were PDE4B (rs2455012), TXNRD2 (rs3804047), VRK1 and BCL11B (rs7152530), and PNPLA5 (rs470093).
Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.
Brown et al., Ithaca, United States. In Plos One, 2012
Transient transfection of truncated versions of human adipose triglyceride lipase (ATGL, also known as PNPLA2), PNPLA3/adiponutrin, or PNPLA5 (GS2-like) fused to GFP revealed that the C-terminal third of these proteins contains sequences that are sufficient for targeting to LDs.
Genetic variance in the adiponutrin gene family and childhood obesity.
Ridderstråle et al., Lund, Sweden. In Plos One, 2008
No association between genetic variants in PNPLA5 genes and childhood and adolescent obesity
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.
Gimeno et al., Cambridge, United States. In J Lipid Res, 2005
Using bioinformatics, we identified three additional Adiponutrin family members (GS2, GS2-Like, and PNPLA1).
share on facebooktweetadd +1mail to friends