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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Promyelocytic leukemia

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, RAR, HAD, Ubiquitin
Papers using PML antibodies
SUMO modification regulates the transcriptional activity of FLASH.
Tsilibary Effie C., In PLoS ONE, 2008
... β-tubulin (sc-5274), mouse monoclonal anti-p53 (sc-126), rabbit anti-FLASH M300 (sc-9088), mouse anti-NPAT (sc-136007) and mouse anti-PML (sc-966), mouse anti-FLIPS/L (sc-5276), rabbit anti-IKKα (sc7607) (Santa Cruz Biotechnology, Santa Cruz, CA); rabbit ...
The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.
Jin Dong-Yan, In PLoS ONE, 2000
... (Sigma-Aldrich), mouse monoclonal anti-penta-His (Qiagen), mouse monoclonal anti-RGS-His (Qiagen), mouse monoclonal anti-S-tag (Novagen), rabbit polyclonal anti-PML (Bethyl Laboratories) and rabbit polyclonal ...
PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins
Sittler Annie et al., In The Journal of Cell Biology, 1999
... HcRFP-PML IV plasmid was generated by subcloning PML IV from pCDNA3 into pHcRed1-C1 vector (CLONTECH Laboratories, Inc.) ...
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
Dasso Mary et al., In The Journal of Cell Biology, 1999
... Monoclonal mouse antibody (PG-M3) against PML was obtained from Santa Cruz Biotechnology, Inc ...
Dual-axis tomography: an approach with alignment methods that preserve resolution.
Everett Roger D., In PLoS Pathogens, 1996
... Melanoma cells expressing doxycyline-inducible PML IV were constructed using the pRetro-X-Tet-On-Advanced vector system and pRetro-X-Tight-Pur plasmid (Clontech Laboratories) with the PML ...
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Papers on PML
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
Bultynck et al., Leuven, Belgium. In Biochim Biophys Acta, Feb 2016
An important aspect of this is the identification of several major oncogenes, including Bcl-2, Bcl-XL, Mcl-1, PKB/Akt, and Ras, and tumor suppressors, such as p53, PTEN, PML, BRCA1, and Beclin 1, as direct and critical regulators of Ca(2+)-transport systems located at the ER membranes, including IP3 receptors and SERCA Ca(2+) pumps.
Progressive Multifocal Leukencephalopathy in Primary Immune Deficiencies: STAT1 Gain of Function and Review of the Literature.
Holland et al., Frederick, United States. In Clin Infect Dis, Feb 2016
BACKGROUND:  Progressive multifocal leukencephalopathy (PML) is a rare, severe, otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically occurs only in the immunocompromised patients.
Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia.
Lo-Coco et al., Roma, Italy. In Br J Haematol, Feb 2016
UNASSIGNED: Acute promyelocytic leukaemia (APL) is characterized by the PML/RARA fusion transcript.
Treatment options for progressive multifocal leukoencephalopathy in HIV-infected persons: current status and future directions.
Toma et al., Montréal, Canada. In Expert Rev Anti Infect Ther, Feb 2016
UNASSIGNED: Progressive multifocal encephalopathy (PML) caused by JC virus was frequently encountered in AIDS patients before combination antiretroviral therapy (cART).
Lipid droplets go nuclear.
Walther et al., Cambridge, United States. In J Cell Biol, Feb 2016
show that the nuclear membrane, promyelocytic leukemia bodies, and the protein PML-II play a role in nuclear LD formation, suggesting functional relationships between these structures.
The potential role for ocrelizumab in the treatment of multiple sclerosis: current evidence and future prospects.
Blinkenberg et al., Copenhagen, Denmark. In Ther Adv Neurol Disord, Jan 2016
However, progressive multifocal leukoencephalopathy (PML) has been reported in patients treated with anti-CD20 monoclonal antibodies for other indications.
Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies.
Meshinchi et al., Wilmington, United States. In Hematology Am Soc Hematol Educ Program, Jan 2016
Acute promyelocytic leukemia (APL) is characterized commonly by a fusion between the PML gene and the RARA gene, genes targetable by arsenic (ATO) and retinoic acid (ATRA), respectively.
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
So et al., Hong Kong, Hong Kong. In Nat Med, Dec 2015
Here we demonstrate that AML driven by repressive transcription factors, including AML1-ETO (encoded by the fusion oncogene RUNX1-RUNX1T1) and PML-RARα fusion oncoproteins (encoded by PML-RARA) are extremely sensitive to poly (ADP-ribose) polymerase (PARP) inhibition, in part owing to their suppressed expression of key homologous recombination (HR)-associated genes and their compromised DNA-damage response (DDR).
HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation.
Zhe et al., Guiyang, China. In Oncol Lett, Nov 2015
The promyelocytic leukemia (PML) gene inhibits cell proliferation and tumor growth, participates in the differentiation of hematopoietic progenitor cells and induces cell apoptosis.
[Significance of PLSCR1 in Matrine Induced Differentiation of ATRA Resistant APL Cells].
Zhou et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
OBJECTIVE: To observe the expression of phospholipid scramblase 1 (PLSCR1) in matrine (MAT) induced differentiation of all-trans retinoic acid (ATRA) resistant acute promyelocytic leukemia (APL) cells, and to explore its correlation to cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signal pathway.
[Everolimus combined with all-trans retinoid acid reverses drug resistance in acute promyelocytic leukemia NB4-R1 cells].
He et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Jun 2015
OBJECTIVE: To investigate the effect of everolimus(RAD001)combined with all-trans retinoid acid(ATRA) on drug resistance of ATRA-resistance acute promyelocytic leukemia(APL) cell line NB4-R1 and its molecular mechanism.
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
Lu et al., Boston, United States. In Nat Med, May 2015
By using mechanism-based screening, here we find that all-trans retinoic acid (ATRA)--a therapy for acute promyelocytic leukemia (APL) that is considered the first example of targeted therapy in cancer, but whose drug target remains elusive--inhibits and degrades active Pin1 selectively in cancer cells by directly binding to the substrate phosphate- and proline-binding pockets in the Pin1 active site.
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.
de Thé et al., Paris, France. In Nat Med, 2014
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB) assembly.
An endogenous accelerator for viral gene expression confers a fitness advantage.
Weinberger et al., San Francisco, United States. In Cell, 2013
We map the accelerator to a highly self-cooperative transcriptional negative-feedback loop (Hill coefficient ∼7) generated by homomultimerization of the virus's essential transactivator protein IE2 at nuclear PML bodies.
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.
O'Shea et al., Los Angeles, United States. In Cell, 2012
E4-ORF3 forms a nuclear polymer and simultaneously inactivates p53, PML, TRIM24, and MRE11/RAD50/NBS1 (MRN) tumor suppressors.
Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation.
Tang et al., Beijing, China. In J Biol Chem, 2012
Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation.
A metabolic prosurvival role for PML in breast cancer.
Pandolfi et al., Boston, United States. In J Clin Invest, 2012
PML expression in breast cancer correlated strikingly with reduced time to recurrence, a gene signature of poor prognosis, and activated PPAR signaling.
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Pandolfi et al., Boston, United States. In Nat Med, 2012
A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells.
Hodny et al., Praha, Czech Republic. In J Biol Chem, 2012
As IL6 is induced in response to various viral and genotoxic stresses, this cytokine may regulate autocrine/paracrine induction of PML under these pathophysiological states
Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).
Kao et al., Cleveland, United States. In J Biol Chem, 2012
Data indicate that promyelocytic leukemia protein (PML) functions as a negative regulator in endothelial cell network formation and migration.
More papers using PML antibodies
All-trans retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia
de Thé Hugues et al., In The Journal of Experimental Medicine, 1994
... Leukemic cells were isolated from bone marrow and spleen of leukemic hMRP8-PML/RARα transgenic mice (leukemia 935) as ...
A rapid method of total lipid extraction and purification.
Koutsopoulos Sotirios, In PLoS ONE, 1958
... , then the fragment was subcloned into the Pml I site of pGEMT-T-T21D12.3
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