gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein phosphatase methylesterase 1

PmeI, PME-1, PPE1
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 [PubMed 10318862]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, PP2A, ACID, HAD, V1a
Papers on PmeI
Regulation of cell wall remodeling in grapevine (Vitis vinifera L.) callus under individual mineral stress deficiency.
Amâncio et al., Lisbon, Portugal. In J Plant Physiol, Jan 2016
While methylesterification patterns can be associated to PME/PMEI gene expression, the lower cellulose content cannot be attributed to altered cellulose synthase (CesA) gene expression suggesting the involvement of other gene families.
Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.
Sundström et al., Turku, Finland. In Cancer Med, Dec 2015
Here, we report the role of PP2A inhibitor PME-1 in CRC.
Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.
Westermarck et al., Helsinki, Finland. In Mol Cell Proteomics, Dec 2015
We demonstrate the versatility of RRP to enable a systematic prioritization of the most relevant interaction partners from high content data, highlighted by the analysis of cancer relevant protein interactions for oncoproteins Pin1 and PME-1.
Efficient construction of recombinant adenovirus expression vector of the Qinchuan cattle LYRM1 gene.
Zan et al., China. In Genet Mol Res, 2014
After linearization of pAdTrack-CMV-LYRM1 and the negative control vector pAdTrack-CMV by restriction endonuclease PmeI, the vectors were transformed into Escherichia coli BJ5183 containing pAdEasy-1 to obtain the recombinant adenovirus vector pAd-LYRM1 and pAd-CMV through homologous recombination.
Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues.
Jonassen et al., Stavanger, Norway. In Plant Cell Environ, 2014
A system with key regulatory proteins (TAP46, TIP41, PTPA, LCMT1, PME-1) is present in all eukaryotes to stabilize, activate and inactivate the catalytic subunits.
Heritability of predicted daily enteric methane emissions from growing Nellore cattle.
Branco et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
The PME of each animal, obtained as MJ/day and converted to g/day, was estimated using three equations: PME1 (MJ/day) = 2.29 + 0.647 x DMI (kg/day), PME2 (MJ/day) = 3.96 + 0.561 x DMI (kg/day), and PME3 (MJ/day) = 4.41 + 0.50 x DMI (kg/day).
Identification of miRNAs with potential roles in regulation of anther development and male-sterility in 7B-1 male-sterile tomato mutant.
Fellner et al., Olomouc, Czech Republic. In Bmc Genomics, 2014
In situ hybridization showed predominant expression of miR159, GAMYBL1, PMEI and cystatin in tapetum, tetrads and microspores.
Antioxidant Properties of Essential Oil Extracted from Pinus morrisonicola Hay Needles by Supercritical Fluid and Identification of Possible Active Compounds by GC/MS.
Song et al., T'ai-chung-shih, Taiwan. In Molecules, 2014
Nine PM needle extracts (PME1-9) were obtained in 1%-4% yields using different SFE conditions, of which PME1 had the lowest yield (1.1%) and PME3 the highest (3.9%).
Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.
Sato et al., Yamaguchi, Japan. In Plos One, 2014
Protein phosphatase methyl esterase (PME-1) catalyzes specifically the demethylation of the C-terminal Leu309 residue of PP2A catalytic subunit (PP2Ac).
β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.
Paterson et al., Australia. In Clin Microbiol Rev, 2013
These include PER-7, GES-11, and PME-1.
The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
Janssens et al., Leuven, Belgium. In Febs J, 2013
In this review, we highlight how PP2A holoenzyme biogenesis and enzymatic activity are controlled by a sophisticatedly coordinated network of five PP2A modulators, consisting of α4, phosphatase 2A phosphatase activator (PTPA), leucine carboxyl methyl transferase 1 (LCMT1), PP2A methyl esterase 1 (PME-1) and, potentially, target of rapamycin signaling pathway regulator-like 1 (TIPRL1), which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
Liu et al., Wuhan, China. In Febs Lett, 2012
GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1
Probe Development Efforts to Identify Novel Inhibitors of ABHD10
Rosen et al., Bethesda, United States. In Unknown Journal, 2012
The Scripps Research Institute Molecular Screening Center (SRIMSC) recently completed a fluorescence-polarization activity-based protein profiling (fluopol-ABPP) high throughput screening (HTS) campaign to identify inhibitors of protein phosphatase methylesterase-1 (PME-1).
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Cravatt et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2011
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells.
Sontag et al., Newcastle, Australia. In J Neurochem, 2010
PME-1 plays a critical role in differentiation of neuroblastoma cells.
Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)
Rosen et al., Bethesda, United States. In Unknown Journal, 2010
Protein phosphatase methylesterase-1 (PME-1) is specifically responsible for demethylation of the carboxyl terminus.
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
Westermarck et al., Turku, Finland. In Cancer Res, 2009
Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Shi et al., Princeton, United States. In Cell, 2008
Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from yeast to humans.
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
Cravatt et al., Los Angeles, United States. In Plos One, 2007
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues
11 Reversible methylation of protein phosphatase 2A.
Goris et al., Leuven, Belgium. In Enzymes, 2005
PP2A has been shown to be methylated at the C-terminal leucine residue of the catalytic subunit by a specific 38 kDa methyltransferase (LCMT1) and demethylated by a specific 44-kDa methylesterase (PME-1).
share on facebooktweetadd +1mail to friends