GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
BPI fold containing family A, member 1
PLUNC, SPLUNC1, LUNX, Spurt
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2011] (from
NCBI)
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4E-BP1, CAN, HAD, ACID, POLYMERASE
Papers on
PLUNC
Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment.
Review
New
Shanghai, China. In Curr Opin Allergy Clin Immunol, Feb 2016
PURPOSE OF REVIEW: Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) is an epithelium-secreted protein that is involved in innate immunity.
New insights on the palate, lung, and nasal epithelium clone (PLUNC) proteins: Based on molecular and functional analysis of its homologue of YH1/SPLUNC1.
New
Dongguan, China. In Exp Mol Pathol, Jan 2016
UNASSIGNED: The palate, lung, and nasal epithelium clone (PLUNC) proteins are intricate immune molecules and arised questions from them are still unresolved.
Lung specific X protein as a novel therapeutic target for lung cancer.
New
Taiwan. In Oncoimmunology, Dec 2015
We found lung-specific X protein (LunX) is overexpressed in lung cancer and promotes primary tumor growth and metastatic colonization.
Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED).
New
Erlangen, Germany. In Invest Ophthalmol Vis Sci, Dec 2015
PURPOSE: Palate Lung Nasal Clone (PLUNC) is a hydrophobic protein belonging to the family of surfactant proteins that is involved in fluid balance regulation of the lung.
Protein profiles of nasal lavage fluid from individuals with work-related upper airway symptoms associated to moldy and damp buildings.
New
Linköping, Sweden. In Indoor Air, Nov 2015
Measurements of innate immunity proteins showed a significant increase of protein S100-A8 and decrease of SPLUNC1 in subjects from one workplace while alpha-1-antitrypsin was elevated in subjects from the other workplace, compared to healthy controls.
Automated acquisition and analysis of airway surface liquid height by confocal microscopy.
New
South Korea. In Am J Physiol Lung Cell Mol Physiol, Aug 2015
As proofs of concept, we generated a time course for ASL absorption and a dose response in the presence of SPLUNC1, a known epithelial sodium channel inhibitor, on human bronchial epithelial cultures.
SPLUNC1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the EB virus by inhibiting the TLR9/NF-κB pathway.
New
Changsha, China. In Oncol Rep, Jun 2015
Studies indicate that the natural immune-related protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) plays an antitumor role in nasopharyngeal epithelial tissue.
SPLUNC1 Is a Significant Marker in Pleural Effusion from Lung Cancer Compared to Tuberculosis.
New
Jingzhou, China. In Monoclon Antib Immunodiagn Immunother, Jun 2015
SPLUNC1 (Short palate, lung and nasal epithelium clone1) protein is an abundant secretory product of epithelia present throughout the conducting airways.
Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.
Review
New
New Haven, United States. In Am J Respir Cell Mol Biol, May 2015
Bactericidal/permeability-increasing protein fold-containing family member A1 (BPIFA1), formerly known as SPLUNC1, is one of the most abundant proteins in respiratory secretions and has been identified with increasing frequency in studies of pulmonary disease.
Detection of CK19, LUNX, and KS1/4 mRNA expression in the peripheral blood for diagnosis of micrometastases in patients with non-small cell lung cancer and their clinical implications.
Hohhot, China. In Genet Mol Res, 2014
The expression of CK19, LUNX, and KS1/4 mRNA biomarkers was detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients to investigate the feasibility of indicating lung cancer micrometastases.
Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells.
Taiwan. In Plos One, 2014
Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is expressed in human nasopharyngeal and respiratory epithelium and has demonstrated antimicrobial activity.
Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice.
Denver, United States. In Plos One, 2014
At day 1 and day 3 post PA infection, lung inflammation, PA load as well as host defence protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) were measured.
Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration.
Review
Chapel Hill, United States. In Int J Biochem Cell Biol, 2014
Interestingly, the recently crystallized short palate lung and nasal epithelial clone 1 (SPLUNC1) protein appears to be a multi-functional protein.
Detection of minimal residual disease in lung cancer.
Review
Olomouc, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2014
Of these, the most specific for lung cancer, appears to be the LunX protein.
Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis.
GeneRIF
Chicago, United States. In Allergy, 2012
Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis
Salivary defense proteins: their network and role in innate and acquired oral immunity.
Review
Budapest, Hungary. In Int J Mol Sci, 2011
Cationic peptides and other defense proteins like lysozyme, bactericidal/permeability increasing protein (BPI), BPI-like proteins, PLUNC (palate lung and nasal epithelial clone) proteins, salivary amylase, cystatins, prolin-rich proteins, mucins, peroxidases, statherin and others are primarily responsible for innate immunity.
Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection.
GeneRIF
Linköping, Sweden. In Proteomics Clin Appl, 2011
RSV-positive boys had significantly less 25 kDa SPLUNC1 than RSV-negative boys while there were no significant differences among girls
PLUNC: a multifunctional surfactant of the airways.
GeneRIF
Iowa City, United States. In Biochem Soc Trans, 2011
PLUNC is a multifunctional protein, which plays a novel role in airway defences at the air/liquid interface
Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria.
Review
GeneRIF
Pittsburgh, United States. In Biochem Soc Trans, 2011
Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria
Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.
GeneRIF
Pittsburgh, United States. In J Immunol, 2011
PLUNC transgene is associated with enhanced bacterial killing and decreased inflammation after exposure with a major human airway pathogen, the Gram-negative bacterium Pseudomonas aeruginosa, both in vitro and in vivo.
