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Phospholipase C, beta 3

PLCbeta3, phospholipase Cbeta3, PLCB3
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: PLC, V1a, PLCgamma, HAD, CAN
Papers on PLCbeta3
Effect evaluation of cisplatin-gemcitabine combination chemotherapy for advanced non-small cell lung cancer patients using microarray data.
Wang et al., Hangzhou, China. In Eur Rev Med Pharmacol Sci, Feb 2015
RELA and PLCB3 correlated with PLCE1 and INADL were hub nodes in the PPI network.
Pathway Analysis Based on a Genome-Wide Association Study of Polycystic Ovary Syndrome.
Kim et al., Seoul, South Korea. In Plos One, 2014
In addition, INS, GNAQ, STXBP1, PLCB3, PLCB2, SMC3 and PLCZ1 were significant genes observed within the biological pathways (all gene P-values < 0.05).
Ovarian superstimulation using FSH combined with equine chorionic gonadotropin (eCG) upregulates mRNA-encoding proteins involved with LH receptor intracellular signaling in granulosa cells from Nelore cows.
Barros et al., Botucatu, Brazil. In Theriogenology, 2014
Although the P-36 protocol did not regulate mRNA expression of the proteins involved in the signaling mechanisms of the cAMP and IP3 systems, the constant presence of GNAS, GNAQ, GNA11, PLCB1, PLCB3, PLCB4, and adenylyl cyclase isoforms (ADCY3, ADCY4, ADCY6, and ADCY9) mRNA and the upregulation of these genes in granulosa cells from cows submitted to P-36/eCG protocol reinforce the participation of Gq/11/PLC/IP3 signaling as well as Gs-protein/adenylyl cyclase/cAMP system on LHR pathways during bovine granulosa cell differentiation submitted to superstimulatory treatments.
Critical role for mast cell Stat5 activity in skin inflammation.
Kawakami et al., Los Angeles, United States. In Cell Rep, 2014
Mast cells were required for both AD models and remarkably increased in the skin of Plcb3(-/-) mice because of the increased Stat5 and reduced SHP-1 activities.
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Stephens et al., Cambridge, United Kingdom. In Embo J, 2012
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-β3 (PLC-β3)-specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors.
Suh et al., South Korea. In J Biol Chem, 2012
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-beta3 (PLC-beta3)-specific activation of somatostatin by forming a ternary complex with PLC-beta3 and somatostatin receptors.
Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses.
Hedin et al., Rochester, United States. In J Immunol, 2011
Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer uses PLC-beta3 to activate the Ras-ERK pathway and increase intracellular calcium ion concentrations
Phospholipase Cβ3 mediates LH-induced granulosa cell differentiation.
Diaz et al., Edinburgh, United Kingdom. In Endocrinology, 2011
Among the four known PLCβ isoforms, PLCβ3 (PLCB3) was specifically up-regulated in cells from ovulatory-size follicles, in association with a predominantly cytoplasmic location of PLCB3 in these cells and a significant inositol phosphate response to LH stimulation.
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1.
Kawakami et al., Los Angeles, United States. In Immunity, 2011
defined a PLC-beta3- and SHP-1-mediated signaling pathway for FcvarepsilonRI-mediated cytokine production
Phospholipase C-β3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells.
Cabrini et al., Verona, Italy. In J Immunol, 2011
Data demonstrate that PLCB3, by regulating intracellular calcium transients, plays a relevant role in amplifying the expression and release of IL-8, the major chemokine recruiting neutrophils in CF airway lungs.
The SPS affair: a complex tale of illicit proliferation.
Shannon et al., San Francisco, United States. In Cancer Cell, 2009
In this issue of Cancer Cell, Xiao et al. report that PLC-beta3 mutant mice develop myeloprolfierative neoplasms and show that tumor suppressor activity does not require PLC-beta3 catalytic activity.
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Kawakami et al., Los Angeles, United States. In Cancer Cell, 2009
Deficiencies in PLC-beta3 are associated with the development of myeloproliferative disease, lymphoma, and other tumors.
Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium.
Stutts et al., Hong Kong, Hong Kong. In Proc Am Thorac Soc, 2003
Inhibition of ENaC by P2Y2 receptors appears to be mediated by phospholipase C-beta3, possibly through an effect on the levels of phosphatidylinositol 4,5-bisphosphonate in the apical membrane.
[Direct involvement of the supraspinal phosphoinositide 3-kinase/phospholipase C gamma 1 pathway in the mu-opioid receptor agonist-induced supraspinal antinociception in the mouse].
Narita, Tokyo, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2003
Here I demonstrate that PLC beta 3 isoform activated by beta gamma subunit of G-protein (G beta gamma) in the brain may contribute to the negative modulation for supraspinal antinociception induced by morphine in mice.
The roles of PDZ-containing proteins in PLC-beta-mediated signaling.
Kim et al., South Korea. In Biochem Biophys Res Commun, 2001
In addition, PLC-beta3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif.
Function and regulation of chemoattractant receptors.
Snyderman et al., Durham, United States. In Immunol Res, 1999
These may include modulation of G-protein activation by regulators of G-protein signaling (RGS) and modification of phospholipase C. Phosphorylation of phospholipase Cbeta3 by both protein kinase A and protein kinase C has been demonstrated.
Immunoreceptor tyrosine-based inhibitory motifs on activating molecules.
Sinclair, London, Canada. In Crit Rev Immunol, 1999
ITIMs with the restricted consensus sequence occur on IL-4Ralpha, IL-3Rbeta type II, gp130 cytokineR, OB-R (leptinR), LIF-Rbeta TNF-RI, G-CSF-R, PDGF-R, Blk, Ctk/Ntk, Lsk, Zap-70, PKB/RACalpha, PKC-alpha, PKC-beta, PKC-gamma, PKC-delta, PKC-zeta, PKC-epsilon, PKC-eta, PKC-phi, PKC-mu, calmodulin-dependent kinase IIdelta, SLP-76-associated protein, FYN-binding protein, Shc binding protein, RasGRF2, CDC25 homologue, Jak2, Jak3, PLCbeta1, and PLCbeta3.
An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling.
Cockcroft et al., London, United Kingdom. In Cell, 1993
Based on the in vitro effects of PI-TP, we surmise that it is involved in transporting PI from intracellular compartments for conversion to PI bisphosphate (PIP2) prior to hydrolysis by PLC-beta 2/PLC-beta 3, the endogenous PLC isoforms present in these cells.
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