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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Plasminogen, Plasmin
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: PAI-1, CAN, HAD, uPA, AGE
Papers on Plasminogen
Plasmin in Parasitic Chronic Infections: Friend or Foe?
Simón et al., Salamanca, Spain. In Trends Parasitol, Feb 2016
UNASSIGNED: Plasmin is the final product of the fibrinolytic system, the physiological mechanism responsible for dissolving fibrin clots.
Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
Gascon et al., Barcelona, Spain. In Plos Negl Trop Dis, Jan 2016
Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment.
Enzymatic Vitrectomy and Pharmacologic Vitreodynamics.
Trese et al., In Dev Ophthalmol, Dec 2015
Plasmin can successfully cause vitreous liquefaction and induce a posterior vitreous detachment.
uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis.
Matsuo et al., Tanabe, Japan. In Int J Biol Sci, Dec 2015
We herein investigated that the effect of urokinase-type plasminogen activator (uPA) on inflammatory osteoclastogenesis induced by lipopolysaccharide (LPS), which is a potent stimulator of bone resorption in inflammatory diseases.
Cancer therapy targeting the fibrinolytic system.
Hattori et al., Tokyo, Japan. In Adv Drug Deliv Rev, Dec 2015
Extracellular matrix breakdown achieved by proteases like the fibrinolytic factor plasmin and matrix metalloproteases is necessary for cell migration crucial for cancer invasion and metastasis.
Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III.
MISTIE and CLEAR Investigators et al., Baltimore, United States. In Stroke, Sep 2015
METHODS: In Minimally Invasive Surgery Plus Recombinant Tissue-Type Plasminogen Activator for Intracerebral Hemorrhage Evacuation-II (MISTIE-II), Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR-IVH) and CLEAR-III trials.
Grinenko et al., In Ukr Biochem J, Sep 2015
In the same benign lesions, 6.7-, 4-, and 3.7-fold increase in plasminogen 50 kDa fragment (angiostatin) levels as compared with control were also observed.
Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking.
van Buul et al., Amsterdam, Netherlands. In Plos One, 2014
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells.
Double Bolus Thrombolysis for Suspected Massive Pulmonary Embolism during Cardiac Arrest.
Gilligan et al., Dublin, Ireland. In Case Rep Emerg Med, 2014
Notwithstanding the relative lack of high-level evidence, this case suggests a scenario in which recombinant tissue Plasminogen Activator (rtPA) may be beneficial in cardiac arrest.
Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer.
Kwaan et al., Chicago, United States. In Adv Exp Med Biol, 2014
Members of the plasminogen-plasmin (PP) system participate in many physiologic functions.
Serpins promote cancer cell survival and vascular co-option in brain metastasis.
Massagué et al., New York City, United States. In Cell, 2014
Here, we identify plasmin from the reactive brain stroma as a defense against metastatic invasion, and plasminogen activator (PA) inhibitory serpins in cancer cells as a shield against this defense.
Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain.
Mackay et al., L'Aquila, Italy. In Febs Lett, 2012
Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.
Park et al., Suwŏn, South Korea. In J Biol Chem, 2012
Plasmin cleaved mainly the N-terminal region of alpha-syn and also inhibited the translocation of extracellular alpha-syn into the neighboring cells in addition to the activation of microglia and astrocytes by extracellular alpha-syn.
Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms.
Reed et al., Memphis, United States. In J Biol Chem, 2012
SUPA formed a higher avidity complex (118-fold) with bovine Pg than with human Pg and non-proteolytically activated bovine but not human Pg.
Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro.
Wachowicz et al., Łódź, Poland. In Int J Biol Macromol, 2012
homocysteine and its thiolactone may affect fibrinolytic properties of plasminogen and plasma, leading to the decrease of plasmin activity
Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.
Candela et al., Bologna, Italy. In Appl Environ Microbiol, 2012
TNF-alpha modulateds the plasminogen-mediated Bifidobacterium animalis subsp. lactis -enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.
Platelet inhibition with cangrelor in patients undergoing PCI.
Bhatt et al., Durham, United States. In N Engl J Med, 2010
The rate of major bleeding (according to Acute Catheterization and Urgent Intervention Triage Strategy criteria) was higher with cangrelor, a difference that approached statistical significance (3.6% vs. 2.9%; odds ratio, 1.26; 95% CI, 0.99 to 1.60; P=0.06), but this was not the case with major bleeding (according to the Thrombolysis in Myocardial Infarction criteria) or severe or life-threatening bleeding (according to Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria).
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
DeClerck et al., Los Angeles, United States. In Cancer Cell, 2008
Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known.
Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trial.
GUSTO V Investigators et al., Cleveland, United States. In Lancet, 2001
BACKGROUND: Plasminogen activator therapy for acute myocardial infarction is limited by lack of achievement of early, complete, and sustained reperfusion in a substantial proportion of patients.
Functional evaluation of plasmin formation in primary breast cancer.
Sappino et al., Genève, Switzerland. In J Clin Oncol, 2001
PURPOSE: Plasmin generation is controlled by the plasminogen activators (PA)/plasmin system, which comprises proteases (urokinase-type PA [uPA] and tissue-type PA [tPA]) and antiproteases (PA inhibitors, PAI-1 and PAI-2).
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