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Pleiomorphic adenoma gene 1

PLAG1, pleomorphic adenoma gene 1
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HMGA2, HAD, Insulin-Like Growth Factor II, Insulin
Papers using PLAG1 antibodies
Identification and expansion of human colon-cancer-initiating cells.
Shi Songtao, In PLoS ONE, 2006
... MMTV-PLAG1 transgenic mice ...
Papers on PLAG1
Emerging role of PLAG1 as a regulator of growth and reproduction.
De Groef et al., Huddinge, Sweden. In J Endocrinol, Feb 2016
Pleomorphic adenoma gene 1 (PLAG1) belongs to the PLAG family of zinc finger transcription factors along with PLAG-like 1 and PLAG-like 2. The PLAG1 gene is best known as an oncogene associated with certain types of cancer, most notably pleomorphic adenomas of the salivary gland.
The relationship between prenatal exposure to BP-3 and Hirschsprung's disease.
Xia et al., Nanjing, China. In Chemosphere, Feb 2016
What's more, we discovered dose-response relationship between RET expression and BP-3 exposure dose, and miR-218 and some other genes involved in SLIT2/ROBO1-miR-218-RET/PLAG1 pathway were also related to BP-3 exposure.
Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature.
Travis et al., Nagasaki, Japan. In Am J Surg Pathol, Feb 2016
We examined the histologic and immunohistochemical features of 8 primary thoracic MTs and performed fluorescence in situ hybridization for EWSR1, FUS, PLAG1, and HMGA2, as well as several partner genes.
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
Leiomyomas with HMGA2 aberrations displayed highly significant up-regulation of the proto-oncogene pleomorphic adenoma gene 1 (PLAG1), suggesting that HMGA2 promotes tumorigenesis through PLAG1 activation.
Genome-Wide Scan for Adaptive Divergence and Association with Population-Specific Covariates.
Gautier, Montpellier, France. In Genetics, Dec 2015
Among these, four (surrounding the KITLG, KIT, EDN3, and ALB genes) contained SNPs strongly associated with the piebald coloration pattern while a fifth (surrounding PLAG1) could be associated to morphological differences across the populations.
Undifferentiated myxoid lipoblastoma with PLAG1-HAS2 fusion in an infant; morphologically mimicking primitive myxoid mesenchymal tumor of infancy (PMMTI)-diagnostic importance of cytogenetic and molecular testing and literature review.
Li et al., Cincinnati, United States. In Cancer Genet, Dec 2015
In contrast, the presence of PLAG1 (Pleomorphic Adenoma Gene 1) rearrangement is diagnostic for lipoblastoma.
Surgical and Anesthetic Management of a Mediastinal Fatty Tumor: Lipoblastoma.
Cleveland et al., Birmingham, United States. In Ann Thorac Surg, Nov 2015
Final diagnosis can be confirmed using molecular genetic analysis; a genetic hallmark of lipoblastoma is the rearrangement of chromosomal region 8q12 and the PLAG1 gene.
Molecular cytogenetics of pediatric adipocytic tumors.
Pedeutour et al., Nice, France. In Cancer Genet, Oct 2015
The target gene of this rearrangement is PLAG1.
Development of Monoclonal Antibody LpMab-10 Recognizing Non-glycosylated PLAG1/2 Domain Including Thr34 of Human Podoplanin.
Kato et al., Sendai, Japan. In Monoclon Antib Immunodiagn Immunother, Oct 2015
PLAG domain includes three tandem repeats of eight amino acids: PLAG1, PLAG2, and PLAG3.
PLAG1 and NCAPG-LCORL in livestock.
Takasuga, Fukushima, Japan. In Anim Sci J, Sep 2015
PLAG1 and/or NCAPG-LCORL, both of which are known as a locus for adult human height, have been detected for association with body weight/height in cattle and horses, and for selective sweep in dogs and pigs.
[Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province].
He et al., Sanya, China. In Nan Fang Yi Ke Da Xue Xue Bao, Aug 2015
OBJECTIVE: To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province.
A meta analysis of genome-wide association studies for limb bone lengths in four pig populations.
Huang et al., Nanchang, China. In Bmc Genet, 2014
Another promising locus is located in the middle of SSC4, and Pleiomorphic Adenoma Gene 1 (PLAG1) is a functionally plausible candidate gene underlying the locus.
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Chinnaiyan et al., Ann Arbor, United States. In Genome Med, 2014
Tumor-specific gene fusions can serve as diagnostic biomarkers or help define molecular subtypes of tumors; for example, gene fusions involving oncogenes such as ERG, ETV1, TFE3, NUT, POU5F1, NFIB, PLAG1, and PAX8 are diagnostically useful.
Chromosomal rearrangements in PLAG1 of myoepithelial salivary gland tumours.
Löning et al., Hamburg, Germany. In Anticancer Res, 2012
PLAG1 is evidently not involved in the development of myoepithelial tumours. The proportion of 8q12-alterations in myoepithelial tumours was very low.
A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart.
Fletcher et al., Memphis, United States. In Genes Chromosomes Cancer, 2012
myoepithelial tumors with PLAG1 alteration share a common morphologic phenotype with salivary gland-like morphology and are genetically related to their salivary gland counterpart
PLAG1 expression in mesenchymal tumors: an immunohistochemical study with special emphasis on the pathogenetical distinction between soft tissue myoepithelioma and pleomorphic adenoma of the salivary gland.
Hashimoto et al., Kitakyūshū, Japan. In Pathol Int, 2012
PLAG1 immunohistochemistry is useful for distinguishing lipoblastoma from other lipomatous tumors including liposarcoma.
PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study.
Hashimoto et al., Kitakyūshū, Japan. In Virchows Arch, 2011
close relationship between cutaneous mixed tumors and pleomorphic adenomas of the salivary gland. However, the mechanism of PLAG1 expression in cutaneous mixed tumors appears to be possibly different from that of pleomorphic adenomas.
Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.
Coppieters et al., Liège, Belgium. In Nat Genet, 2011
We further show that two of the eight candidate QTNs, mapping to the PLAG1-CHCHD7 intergenic region, influence bidirectional promoter strength and affect binding of nuclear factors.
Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor.
Zhang et al., Shanghai, China. In Plos One, 2010
Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas.
Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
Van de Ven et al., Leuven, Belgium. In Nat Genet, 1997
We here demonstrate that the t(3;8)(p21;q12) results in promoter swapping between PLAG1, a novel, developmentally regulated zinc finger gene at 8q12, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein interface functioning in the WG/WNT signalling pathway and specification of cell fate during embryogenesis.
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