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Phospholipase A2, group III

PLA2G3, Group III secreted phospholipase A2
PLA2G3 belongs to the family of secreted phospholipase A2 (sPLA2; EC proteins. These Ca(2+)-dependent lipolytic enzymes have a conserved Ca(2+)-binding loop and a his-asp dyad in the catalytic site (Murakami et al., 2003 [PubMed 12522102]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: PLA2, V1a, ACID, MAST, HAD
Papers on PLA2G3
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Swinnen et al., Leuven, Belgium. In Mol Biol Cell, Jul 2015
One of the candidate genes that was consistently up-regulated in cellular models of SREBP1c-induced cilium repression was phospholipase A2 group III (PLA2G3), a phospholipase that hydrolyzes the sn-2 position of glycerophospholipids. Use of RNA interference and a chemical inhibitor of PLA2G3 rescued SREBP1c-induced cilium repression.
Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates.
Wei et al., Nanning, China. In Int J Mol Med, Mar 2015
These methods led us to the following assumptions: i) closer lineages were observed between PLA2G16 and PLA2G6, PLA2G7 and PLA2G4, PLA2G3 and PLA2G12, as well as among PLA2G10, PLA2G5 and PLA2G15; ii) PLA2G5 appeared to be the origin of the PLA2 family, and PLA2G7 was one of the most evolutionarily distant PLA2 proteins; iii) 16 positive-selection sites were detected and were marked in the PLA2G7 protein sequence as 327D, 257Q, 276G, 34s, 66G, 67C, 319S, 28N, 50S, 54T, 58R, 75T, 88Q, 92R, 179H and 191K.
Secreted phospholipase A2 and mast cells.
Taketomi et al., Tokyo, Japan. In Allergol Int, 2015
In particular, we highlight group III sPLA2 (PLA2G3) as an "anaphylactic sPLA2" that promotes MC maturation and thereby anaphylaxis through a previously unrecognized lipid-orchestrated circuit.
Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.
Shridhar et al., Rochester, United States. In Cancer Metab, 2013
Furthermore, HSulf-1 loss induced the expression of lipogenic genes including FASN, SREBF1, PPARĪ³, and PLA2G3 stimulated lipid droplet accumulation.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Murakami et al., Tokyo, Japan. In Nat Immunol, 2013
Here we report that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A2, regulates this process.
Human group III PLA2 as a drug target: structural analysis and inhibitor binding studies.
Kumar et al., New Delhi, India. In Int J Biol Macromol, 2010
The availability of the human group III phospholipase A(2) (hIIIPLA(2)) amino acid sequence offers an opportunity to study its structural features by modeling.
Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons.
DeCoster et al., Chongqing, China. In J Neurochem, 2010
Secreted PLA2 III induces apoptosis of primary cortical neurons in culture by suppressing production of Bcl-xl, promoting Bax, augmenting caspase 3 and cleaving alpha-fodrin.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
Murakami et al., Tokyo, Japan. In J Clin Invest, 2010
Here, we show that group III phospholipase A2 (sPLA2-III), a member of the secreted phospholipase A2 (sPLA2) family, is expressed in the mouse proximal epididymal epithelium and that targeted disruption of the gene encoding this protein (Pla2g3) leads to defects in sperm maturation and fertility.
Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk.
Nieters et al., Heidelberg, Germany. In Carcinogenesis, 2010
A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC.
PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.
Bullido et al., Madrid, Spain. In J Alzheimers Dis, 2009
we describe that PLA2G3 gene silencing produced a marked inhibition of xanthine/xanthine oxidase induced cell death, and that PLA2G3 polymorphisms are associated with Alzheimer disease in a Spanish case-control sample.
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Murakami et al., Tokyo, Japan. In Biochem J, 2009
This study showed that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that transgenic mice overexpressing human PLA2G3 spontaneously develop skin inflammation.
Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
Murakami et al., Tokyo, Japan. In J Biol Chem, 2008
a potential functional link between PLA2G3 and atherosclerosis, as has recently been proposed for PLA2G5 and PLA2G10.
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
Lambeau et al., Antibes, France. In Br J Cancer, 2008
In normal colon, PLA2G2A and PLA2G12A were expressed at high levels, PLA2G2D, PLA2G5, PLA2G10 and PLA2G12B at moderate levels, and PLA2G1B, PLA2G2F and PLA2G3 at low levels.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Murakami et al., Tokyo, Japan. In Biochem J, 2008
potential contribution of sPLA2-III to neuronal differentiation and its function under certain conditions
Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method.
Zagury et al., Rouen, France. In Biomed Pharmacother, 2008
These stronger associations corresponded to both secreted (PLA2G2A, PLA2G2D and PLA2G3) and cytosolic (PLA2G4A and PLA2G6) PLA2 genes, including three (PLA2G2A, PLA2G2D and PLA2G4A) implicated in the pathogenesis of other diseases.
Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures.
DeCoster, New Orleans, United States. In Brain Res, 2003
Secreted phospholipase A(2) (sPLA(2)) has been shown to cause both necrotic and apoptotic neuronal injury in the central nervous system.
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