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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Polycystic kidney disease

This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PC2, ACID, CAN, PC1, fibrillin-1
Papers on PKDREJ
Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents.
Roldan et al., Madrid, Spain. In Mol Hum Reprod, Feb 2015
PKDREJ is a testis-specific protein thought to be located on the sperm surface.
Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.
Duggal et al., Baltimore, United States. In Invest Ophthalmol Vis Sci, 2015
RESULTS: Intraocular pressure was suggestively associated with novel variants located in FAR2 at 12p11.22 (rs4931170, P = 1.2 × 10(-5)), in GGA3 at 17q25.1 (rs52809447, P = 6.7 × 10(-5)), and in PKDREJ at 22q13.31 (rs7291444, P = 7.4 × 10(-5)).
The TRPP subfamily and polycystin-1 proteins.
Hofherr et al., Freiburg, Germany. In Handb Exp Pharmacol, 2013
It has been exciting times since the identification of polycystic kidney disease 1 (PKD1) and PKD2 as the genes mutated in autosomal dominant polycystic kidney disease (ADPKD).
Characterization of sperm surface protein patterns of ejaculated and capacitated boar sperm, with the detection of ZP binding candidates.
Maňásková-Postlerová et al., Praha, Czech Republic. In Int J Biol Macromol, 2013
Angiotensin-converting enzyme (ACE), polycystic kidney disease receptor and egg jelly receptor (PKDREJ), and acrosin precursor were successfully identified.
Evolution of 2 reproductive proteins, ZP3 and PKDREJ, in cetaceans.
Coelho et al., Lisbon, Portugal. In J Hered, 2011
In this study, a range of cetacean species were used to analyze the patterns of evolution in 2 reproductive proteins involved in fertilization: the zona pellucida 3 (ZP3), present in the egg coat, and PKDREJ, localized in the sperm head.
A polycystin-1 controls postcopulatory reproductive selection in mice.
Florman et al., Worcester, United States. In Proc Natl Acad Sci U S A, 2008
Pkdrej controls the timing of fertilization in vivo through effects on sperm transport and exocytotic competence and is a factor in postcopulatory sexual selection.
Evidence of amino acid diversity-enhancing selection within humans and among primates at the candidate sperm-receptor gene PKDREJ.
Swanson et al., Seattle, United States. In Am J Hum Genet, 2007
Here, we present evidence that positive selection has driven the evolution of PKDREJ, a candidate sperm receptor of mammalian egg-coat proteins.
Functional characterization of PKDREJ, a male germ cell-restricted polycystin.
Florman et al., Worcester, United States. In J Cell Physiol, 2006
PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm.
Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head.
Gudermann et al., Marburg an der Lahn, Germany. In Mol Reprod Dev, 2006
The present study focuses on a PKD1 homologue, mouse polycystic kidney disease and receptor for egg jelly (PKDREJ) and its putative role in mammalian fertilization.
A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion.
Vacquier et al., San Diego, United States. In Dev Growth Differ, 2004
All three sea urchin sperm REJ proteins possess a protein module of > 900 amino acids, termed 'the REJ module', that is shared by the human autosomal dominant polycystic kidney disease protein, polycystin-1, and PKDREJ, a testis-specific protein in mammals whose function is unknown.
Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).
Peters et al., Leiden, Netherlands. In Eur J Hum Genet, 1999
Autosomal Dominant Polycystic Kidney Disease (ADPKD), a common inherited disease leading to progressive renal failure, can be caused by a mutation in either the PKD1 or PKD2 gene.
Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein.
Harris et al., Oxford, United Kingdom. In Hum Mol Genet, 1999
Northern analysis showed that this is a functional gene [termed the polycystic kidney disease and receptor for egg jelly related gene ( PKDREJ )], but unlike polycystin-1, has a very restricted expression pattern; the approximately 8 kb transcript was found exclusively in testis, coincident with the timing of sperm maturation.
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