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Protein kinase D3

PKD3, PKCnu, protein kinase D3
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PC2, PC1, CAN, HAD, Inactive
Papers using PKD3 antibodies
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis
Storz Peter et al., In Breast Cancer Research : BCR, 2007
... antibody for PKD2 was from Upstate (Charlottesville, VA, USA), and the rabbit polyclonal antibody for PKD3 was from Bethyl Laboratories (Montgomery, TX, USA) ...
Papers on PKD3
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
Storz et al., Jacksonville, United States. In Cell Mol Life Sci, Nov 2015
The protein kinase D (PKD) family members, PKD1, PKD2 and PKD3 constitute a family of serine/threonine kinases that are essential regulators of cell migration, proliferation and protein transport.
Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.
Storz et al., Jacksonville, United States. In Mol Cancer Ther, Jun 2015
Using progression tissue microarrays, we here demonstrate that the serine/threonine kinase protein kinase D3 (PKD3) is highly upregulated in estrogen receptor (ER)-negative (ER(-)) tumors.
Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.
Ghazizadeh et al., Stony Brook, United States. In J Biol Chem, May 2015
We found that PKD2 and PKD3 are expressed differentially in proliferating and differentiating human KCs, with the former uniformly present in both compartments whereas the latter is predominantly expressed in the proliferating compartment.
A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells.
Kleger et al., Ulm, Germany. In Sci Rep, 2014
We show that mouse ESCs predominantly express PKD2 followed by PKD3 while PKD1 displays negligible levels.
A Case of New Familiar Genetic Variant of Autosomal Dominant Polycystic Kidney Disease-2: A Case Study.
Vasylyeva et al., Amarillo, United States. In Front Pediatr, 2014
and polycystin-2 [PKD2 (10-15% of cases), on ch 4q13-23] and PKD3 gene (gene unmapped).
SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest.
Wang et al., Pittsburgh, United States. In Plos One, 2014
Targeted inhibition of PKD by SD-208 resulted in potent inhibition of cell proliferation, an effect that could be reversed by overexpressed PKD1 or PKD3.
Protein kinase d as a potential chemotherapeutic target for colorectal cancer.
Schmitz et al., Pittsburgh, United States. In Mol Cancer Ther, 2014
PKD3 expression was also observed but PKD1 expression, at both the RNA and protein levels, was not detected.
Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.
Storz et al., Jacksonville, United States. In Plos One, 2013
METHODOLOGY/PRINCIPAL FINDINGS: We here analyzed two cell lines (HeLa and MDA-MB-468) that express the subtypes protein kinase D2 (PKD2) and protein kinase D3 (PKD3).
Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway.
Liu et al., Xiamen, China. In Biomed Res Int, 2013
Here, we show that the protein kinase D3 (PKD3) is essential for prostratin-induced transcription activation of latent HIV-1 provirus.
Protein kinase D is increased and activated in lung epithelial cells and macrophages in idiopathic pulmonary fibrosis.
Tang et al., Tyler, United States. In Plos One, 2013
We found that PKD family kinases (PKD1, PKD2 and PKD3) were increased and activated in the hyperplastic and regenerative alveolar epithelial cells lining remodeled fibrotic alveolar septa and/or fibroblast foci in IPF lungs compared with normal controls.
Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer.
Wang et al., Pittsburgh, United States. In Mol Cancer Ther, 2012
These data validate PKD3 as a promising therapeutic target in prostate cancer and shed light on the role of secreted tumor-promoting factors in prostate cancer progression.
Role of protein kinase D signaling in pancreatic cancer.
Rozengurt et al., Houston, United States. In Biochem Pharmacol, 2011
Protein kinase D1 (PKD or PKD1, initially called atypical PKCμ), is the founding member of a novel protein kinase family that includes two additional protein kinases that share extensive overall homology with PKD, termed PKD2, and PKD3.
A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.
Bart et al., Kuopio, Finland. In Biochim Biophys Acta, 2010
Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation.
[Protein kinases of PKD family as a potential object of translational research in oncology].
Sydorenko et al., In Ukr Biokhim Zh (1999), 2010
That is why studies of differential expression and activity of PKD1, PKD2 and PKD3 in the context of tumor spreading and prognosis could be the perspective subject of translational research in oncology.
Influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C.
Marschall et al., Nürnberg, Germany. In J Gen Virol, 2009
The data suggest that protein kinase C contributes to the phosphorylation of influenza PB1 and NS1 proteins which appears to be functionally relevant for both viral RNA polymerase activity and efficient viral replication.
PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion.
Evers et al., Galveston, United States. In J Biol Chem, 2009
reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase secretion
Expression patterns of protein kinase D 3 during mouse development.
Hausser et al., Stuttgart, Germany. In Bmc Dev Biol, 2007
PKD3 is increasingly expressed in neuronal as well as in the supporting connective tissue and in skeletal muscles
Polycystic kidney disease and infertility: case report and literature review.
Turco et al., Pordenone, Italy. In Arch Ital Urol Androl, 2005
It is an autosomic dominant disease due to mutation of one out of three genes: PKD1 (on the 16th chromosome), PKD2 (on the 4th chromosome) and PKD3 (still unmapped).
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.
Malhotra et al., Iowa City, United States. In Nat Cell Biol, 2004
specificity of different PKD isoforms in regulating protein trafficking from the trans-Golgi network
Protein kinase D: a family affair.
Van Lint et al., Leuven, Belgium. In Febs Lett, 2003
The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu PKD2 and PKD3/PKCnu.
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