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Polycystic kidney disease 1 like 1

Pkd1l1, polycystin-1L1, polycystic kidney disease 1 like 1
This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PC1, PC2, CAN, PKD1L2, Rhodopsin
Papers on Pkd1l1
The Zic2 gene directs the formation and function of node cilia to control cardiac situs.
Arkell et al., Canberra, Australia. In Genesis, 2014
The expression of the Noto, Rfx3, and Foxj1 transcription factors known to regulate ciliogenesis is greatly depleted in the mid-gastrula node of mutants, as is the expression of the Pkd1l1 gene required for cilia function.
Direct recording and molecular identification of the calcium channel of primary cilia.
Clapham et al., Boston, United States. In Nature, 2014
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes: 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell adhesion domains and a G-protein-coupled receptor proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).
Primary cilia are specialized calcium signalling organelles.
Clapham et al., Boston, United States. In Nature, 2014
Here we show that cilia are a unique calcium compartment regulated by a heteromeric TRP channel, PKD1L1-PKD2L1, in mice and humans.
The TRPP subfamily and polycystin-1 proteins.
Hofherr et al., Freiburg, Germany. In Handb Exp Pharmacol, 2013
The identification of additional TRPP (TRPP3 and TRPP5) and polycystin-1-like proteins (PKD1L1, PKD1L2, PKD1L3, and PKDREJ) has added yet another layer of complexity to these fascinating cellular signalling units.
Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis.
Takeda et al., Tokyo, Japan. In Development, 2011
We identify the abc gene as pkd1l1, the expression of which is confined to Kupffer's vesicle (KV, an organ equivalent to the node).
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
Norris et al., United Kingdom. In Development, 2011
Pkd1l1 is the elusive Pkd2 binding partner required for Left-Right patterning.
Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.
Sands et al., The Woodlands, United States. In Vet Pathol, 2010
situs inversus in Pkd1l1-/- knockout mice
Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes.
Edwards et al., Cambridge, United Kingdom. In Oncogene, 2008
Two gene fusions were demonstrated, TAX1BP1-AHCY and RIF1-PKD1L1.
Polycystin-1L2 is a novel G-protein-binding protein.
Zhou et al., Boston, United States. In Genomics, 2004
Furthermore, by GST pull-down assay we observed that PC1L2 and polycystin-1L1 are able to bind to specific G-protein subunits.
The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.
Zhou et al., Boston, United States. In Genomics, 2002
In this study, we describe a sixth member of the family, polycystin-1L1, encoded by PKD1L1 in human.
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