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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prokineticin 2

PK2, Bv8, prokineticin 2, PROK2, MITI
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PKR2, ACID, CAN, HAD, FGFR1
Papers using PK2 antibodies
The mouse brain in stereotaxic coordinates.
Nitabach Michael N., In PLoS ONE, 2000
... A PK2-EGFP transgenic mouse was generated by ...
Papers on PK2
Childhood growth in boys with congenital hypogonadotropic hypogonadism.
Raivio et al., Helsinki, Finland. In Pediatr Res, Jan 2016
Genetically verified diagnosis of CHH was made in 15 (42%) patients (KAL1, FGFR1, GNRHR or PROK2).
Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population.
Zhang et al., Shanghai, China. In Lipids Health Dis, Dec 2015
BACKGROUND: Prokineticin-2 is confirmed to be involved in the inflammatory process.
Prokineticin 2 facilitates mechanical allodynia induced by α,β-methylene ATP in rats.
Hu et al., Xianning, China. In Eur J Pharmacol, Dec 2015
Prokineticin 2 (PK2), a new chemokine, causes mechanical hypersensitivity in the rat hind paw, but little is known about the molecular mechanism.
Prokineticins in central and peripheral control of human reproduction.
Alfaidy et al., In Horm Mol Biol Clin Investig, Dec 2015
Prokineticin 1 (PROK1) and (PROK2), are two closely related proteins that were identified as the mammalian homologs of their two amphibian homologs, mamba intestinal toxin (MIT-1) and Bv8.
Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats.
Zhang et al., Wuhan, China. In Inflammation, Nov 2015
Given one of the cognate receptors of prokineticin 2, prokineticin receptor 1 (PKR1) was also significantly upregulated in orchitis as discussed in the current study, it is very likely that PK2/PKR1 signaling contribute to the development of inflammation-related testicular diseases.
New trends in guided nanotherapies for digestive cancers: A systematic review.
Santos et al., Porto, Portugal. In J Control Release, Aug 2015
To this date only three nanocomplexes have progressed beyond pre-clinical stages: i) PK2, a galactosamine-functionalized polymeric-DOX formulation for hepatocarcinomas; ii) MCC-465, an anti-(myosin heavy chain a) immunoliposome for advanced stage metastatic solid tumors; and iii) MBP-426, a transferrin-liposome-oxaliplatin conjugate, also for advanced stage tumors.
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.
Negri et al., Ferrara, Italy. In Sci Rep, 2014
Bv8/Prokineticin 2 (PROK2) is a bioactive peptide initially discovered as a regulator of gastrointestinal motility.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
Neutrophil-derived cytokines involved in physiological and pathological angiogenesis.
Cassatella et al., Verona, Italy. In Chem Immunol Allergy, 2013
Particular emphasis will be given to VEGF and PK2/Bv8, rather than CXCL8/IL-8 and OSM.
Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.
Ferrara et al., San Francisco, United States. In J Biol Chem, 2012
Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.
Prokineticin 2 is an endangering mediator of cerebral ischemic injury.
Sapolsky et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
findings indicate that PK2 can be activated by pathological stimuli such as hypoxia-ischemia and excitotoxic glutamate and identify PK2 as a deleterious mediator for cerebral ischemia
Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport.
Nash et al., Burgess Hill, United Kingdom. In Neurogastroenterol Motil, 2012
Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors.
PPARγ contributes to PKM2 and HK2 expression in fatty liver.
Pende et al., Paris, France. In Nat Commun, 2011
PPARgamma contributes to PKM2 and HK2 expression in fatty liver
The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.
Crowley et al., Boston, United States. In Endocr Rev, 2011
Among these genes, prokineticin 2 (PROK2), and PROK2 receptor (PROKR2) have recently emerged as critical regulators of reproduction in both mice and humans.
Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons.
Hu et al., Xianning, China. In Plos One, 2010
PK2 could alter cellular activities within the suprachiasmatic nuclei
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Ferrara et al., San Francisco, United States. In Nature, 2008
identification of granulocyte colony-stimulating factor as a major positive regulator of Bv8 expression; anti-Bv8 antibodies reduced CD11b+Gr1+ cell mobilization elicited by granulocyte colony-stimulating factor
Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling.
Zhou et al., Irvine, United States. In Science, 2005
findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult olfactory bulb neurogenesis
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
Zhou et al., Irvine, United States. In Nature, 2002
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin.
Cancer Research Campaign Phase I/II Clinical Trials committee et al., Birmingham, United Kingdom. In J Clin Oncol, 2002
PURPOSE: Preclinical studies have shown good anticancer activity following targeting of a polymer bearing doxorubicin with galactosamine (PK2) to the liver.
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