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PIR1 Pir1p

PIR1, CCW6, PIRI, Pir1p, DUSP11
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: PIR, ACID, CAN, glycosyltransferase, SET
Papers on PIR1
Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression.
Rajabi Bazl et al., Qom, Iran. In Jundishapur J Microbiol, Sep 2015
OBJECTIVES: The current study aimed to find the relationship between fluconazole resistance and Pir1 protein (Pir1p) overexpression in the females with recurrent C. albicans vaginitis requiring longer fluconazole therapy.
Effect of puerarin on expression of Fas/FasL mRNA in pulmonary injury induced by ischemia-reperfusion in rabbits.
Wang et al., In Nat Prod Commun, Feb 2015
The effect of puerarin (Pur) on expressions of Fas/FasL mRNAs in pulmonary ischemia and reperfusion injury (PIRI) in rabbit was investigated.
Integrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infection.
Neefjes et al., Amsterdam, Netherlands. In Acs Chem Biol, 2014
We define host phosphatases inhibiting intracellular growth of Salmonella and identify corresponding inhibitors for the dual specificity phosphatases DUSP11 and 27.
Structure of human PIR1, an atypical dual-specificity phosphatase.
Cingolani et al., Philadelphia, United States. In Biochemistry, 2014
PIR1 is an atypical dual-specificity phosphatase (DSP) that dephosphorylates RNA with a higher specificity than phosphoproteins.
[Effect of siRNA silencing the role of JNK gene in excessive endoplasmic reticulum stress on lung ischemia/reperfusion injury].
Wang et al., In Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2014
METHODS: Mouse model of pulmonary ischemia reperfusion injury (PIRI) in situ was established with unilateral lung in vivo.
[Effects of curcumin on pneumocyte apoptosis and CHOP in pulmonary ischemia/reperfusion injury of mice].
Wang et al., Wenzhou, China. In Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2013
OBJECTIVE: To investigate the effects of curcumin (CUR) on pneumocyte apoptosis and CCAAT/enhancer binding protein homologous protein (CHOP) in pulmonary ischemia/reperfusion injury (PIRI) in mice.
ABC transporters and cell wall proteins involved in organic solvent tolerance in Saccharomyces cerevisiae.
Ueda et al., Kyoto, Japan. In J Biotechnol, 2013
To identify the genes involved in the organic solvent tolerance, we focused on the upregulated 4 ABC transporters and 6 cell wall proteins in KK-211, and demonstrated 2 ABC transporters, Pdr10p and Snq2p, and the 4 cell wall proteins, Wsc3p, Pry3p, Pir1p, and Ynl190wp were responsible for hydrophobic organic solvent (n-decane and n-undecane) tolerance.
The unique hmuY gene sequence as a specific marker of Porphyromonas gingivalis.
Olczak et al., Wrocław, Poland. In Plos One, 2012
We observed a significant correlation between periodontal index of risk of infectiousness (PIRI) and the presence/absence of P. gingivalis (regardless of the hmuY gene-based sequence pattern of the isolate identified [r = 0.43; P = 0.0002] and considering particular isolate pattern [r = 0.38; P = 0.0012]).
Characterization of PIR1, a GATA family transcription factor involved in iron responses in the white-rot fungus Phanerochaete chrysosporium.
Larrondo et al., Santiago, Chile. In Fungal Genet Biol, 2012
Due to the limitation of experimental tools in P. chrysosporium, the alleged Phanerochaete iron regulator (PIR1) was studied by complementation of a Neurospora SRE/URBS1-deficient strain, where phenotypic and molecular characteristics of this transcriptional regulator could be easily assessed.
Alterations of pre-mRNA splicing in human inflammatory bowel disease.
Rosenstiel et al., Kiel, Germany. In Eur J Cell Biol, 2011
To investigate these subtype-specific changes in detail we determined the expression levels of seven splicing factors (DUSP11, HNRPAB, HNRPH3, SLU7, SFR2IP, SFPQ, SF3B14) and three intron retention events (PARC, IER3, FGD2) in a cohort of 165 patients with inflammatory diseases of the colon (120 with IBD) and 30 healthy controls by real time PCR (TaqMan).
Isolation of Pichia pastoris PIR genes and their utilization for cell surface display and recombinant protein secretion.
Inan et al., Lincoln, United States. In Yeast, 2011
The PIR1 and PIR2 genes' open reading frames were found to contain 1068 and 972 bases, respectively.
Common and not so common symbiotic entry.
Szczyglowski et al., London, Canada. In Trends Plant Sci, 2010
In this opinion article, we consider Lotus japonicus nap1 and pir1 symbiotic mutants within the context of other deleterious mutations that impair an intracellular accommodation of bacteria but have no impact on the colonization of roots by AM fungi.
Isolation and characterization of DUSP11, a novel p53 target gene.
Helin et al., Milano, Italy. In J Cell Mol Med, 2009
results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68
Rearrangement of actin cytoskeleton mediates invasion of Lotus japonicus roots by Mesorhizobium loti.
Stougaard et al., Århus, Denmark. In Plant Cell, 2009
We found that two genes, Nap1 (for Nck-associated protein 1) and Pir1 (for 121F-specific p53 inducible RNA), involved in actin rearrangements were essential for infection thread formation and colonization of Lotus japonicus roots by its natural microsymbiont, Mesorhizobium loti.
[Effect of Shenmai injection on expression and activity of heme oxygenase-1 in reperfusion injury after pulmonary ischemia in rabbits].
Dai et al., Wenzhou, China. In Zhongguo Zhong Yao Za Zhi, 2008
Twenty rabbits were randomly divided into two groups (n = 10, in each), pulmonary ischemia and reperfusion injury (PIRI) group and I-R + Shenmai injection group.
Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p.
Jigami et al., Tsukuba, Japan. In Eukaryot Cell, 2005
Data show that bud scars contain proteins like Pir1p as internal components.
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