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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

PIP5KIalpha, PIP5K1A, mPIP5K-Ibeta, PIP5K1B, PIP5KIbeta, phosphatidylinositol-4-phosphate 5-kinase Ialpha
Top mentioned proteins: Actin, HAD, IA1, Fab1, PRKAG2
Papers on PIP5KIalpha
LPS-induced clustering of CD14 triggers generation of PI(4,5)P2.
Kwiatkowska et al., Warsaw, Poland. In J Cell Sci, Dec 2015
After 5-10 min of LPS stimulation, CD14 underwent prominent clustering in the plasma membrane, accompanied by accumulation of PI(4,5)P2 and type-I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) isoforms Iα and Iγ (encoded by Pip5k1a and Pip5k1c, respectively) in the CD14 region.
Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.
Rotimi et al., Bethesda, United States. In J Endocrinol Metab, Jun 2015
Telomere extension by telomerase (HNRNPA1, TNKS2), D-myo-inositol (1, 4, 5)-trisphosphate biosynthesis (PIP5K1A, PIP4K2A), and regulation of actin-based motility by Rho (ARPC3) were the most significant canonical pathways and overlay with T2D signaling pathway.
Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled.
Wu et al., New Haven, United States. In Nat Commun, 2014
Here we report the crystal structure of the catalytic domain of zebrafish PIP5K1A at 3.3 Å resolution.
Generalization of associations of kidney-related genetic loci to American Indians.
Cole et al., Hyattsville, United States. In Clin J Am Soc Nephrol, 2014
RESULTS: This study identified significant associations of single nucleotide polymorphisms with estimated GFR in or nearby PRKAG2, SLC6A13, UBE2Q2, PIP5K1B, and WDR72 (P<2.1 × 10(-3) to account for multiple testing).
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.
Waugh, London, United Kingdom. In J Cancer, 2013
Extending this analysis to subsequent enzymes in the phosphoinositide signalling cascades revealed that the only PIP5K1A, PI3KC2B and AKT3 genes exhibited similar patterns of gene copy number variation.
Novel candidate genes for 46,XY gonadal dysgenesis identified by a customized 1 M array-CGH platform.
Barbaro et al., Stockholm, Sweden. In Eur J Med Genet, 2013
A large duplication highlighting PIP5K1B, PRKACG and FAM189A2 as candidates for 46,XY GD, were also detected.
Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.
Divecha et al., Manchester, United Kingdom. In Biochem J, 2013
PIP5K1B is negatively regulated in response to oxidative stress although it remains unclear which pathways regulate its activity.
Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies.
Rustin et al., Paris, France. In Hum Mol Genet, 2013
We show here that gene silencing spreads in cis over the PIP5K1B gene in cells from FRDA patients (circulating lymphocytes and primary fibroblasts), correlating with expanded GAA repeat size.
Novel genes that mediate nuclear respiratory factor 1-regualted neurite outgrowth in neuroblastoma IMR-32 cells.
Huang et al., Tainan City, Taiwan. In Gene, 2013
Fifteen genes, MAPRE3, NPDC1, RAB3IP, TRAPPC3, SMAD5, PIP5K1A, USP10, SPRY4, GTF2F2, NR1D1, SUV39H2, SKA3, RHOA, RAPGEF6, and SMAP1 were selected for biological confirmation.
Friedreich's ataxia, frataxin, PIP5K1B: echo of a distant fracas.
Rustin et al., Paris, France. In Oxid Med Cell Longev, 2012
"Frataxin fracas" were the words used when referring to the frataxin-encoding gene (FXN) burst in as a motive to disqualify an alternative candidate gene, PIP5K1B, as an actor in Friedreich's ataxia (FRDA) (Campuzano et al., 1996; Cossee et al., 1997; Carvajal et al., 1996).
Vitamin D related genes in lung development and asthma pathogenesis.
Tantisira et al., Boston, United States. In Bmc Med Genomics, 2012
4 genes, LAMP3, PIP5K1B, SCARB2 and TXNIP were identified in both groups; each displays significant biologic plausibility for a role in asthma.
Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.
Kanaho et al., Tsukuba, Japan. In Biol Reprod, 2012
The results suggested that PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.
Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.
Frohman et al., Stony Brook, United States. In Diabetes, 2011
Our findings suggest that PI4P5Kalpha plays a complex role in restricting insulin release from pancreatic beta-cells through helping to maintain plasma membrane PIP(2) levels and integrity of the actin cytoskeleton under both basal and stimulatory conditions.
Chronic kidney disease: novel insights from genome-wide association studies.
Heid et al., Regensburg, Germany. In Kidney Blood Press Res, 2010
UMOD, SHROOM3, STC1, LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2/SH2B3, DACH1, UBE2Q2, and SLC7A9 were uncovered as loci associated with estimated glomerular filtration rate (eGFR) and CKD, and CUBN as a locus for albuminuria in cross-sectional data of general population studies.
Genome-wide association studies in nephrology research.
Köttgen, Freiburg, Germany. In Am J Kidney Dis, 2010
For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk of kidney stone disease; and variants in or near SHROOM3, STC1, LASS2, GCKR, NAT8/ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, FAM122A/PIP5K1B, ATXN2, DACH1, UBE2Q2/FBXO22, and SLC7A9, with differences in glomerular filtration rate.
Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses.
Jou et al., Suwŏn, South Korea. In Exp Mol Med, 2010
Ganglioside treatment of primary astrocytes enhances PIP5Kalpha expression. PIP5Kalpha knockdown attenuates ganglioside-induced inflammatory responses.
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation.
Kunz et al., Houston, United States. In J Cell Biol, 2010
Results define the role of PIPKI-alpha in cell migration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for cell migration.
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.
Fukami et al., Tokyo, Japan. In Cancer Sci, 2010
Localized production of Phosphatidylinositol 4,5-bisphosphate by PIP5K1A is required for invadopodia formation by breast cancer cells.
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
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