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Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

PIP5K2A, phosphatidylinositol-4-phosphate 5-kinase IIalpha, PIP5KII
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, RGS4, DTNBP1, V1a, HAD
Papers on PIP5K2A
Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia.
Ivanova et al., Novosibirsk, Russia. In Int J Neuropsychopharmacol, Apr 2015
METHODS: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia.
Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A).
Strutz-Seebohm et al., Münster, Germany. In Pflugers Arch, 2014
Here, we show that glutamate-induced currents in oocytes expressing GluA1 are increased by coexpression of the schizophrenia-associated phosphoinositide kinase PIP5K2A.
[Association of (N251S)-PIP5K2A with schizophrenic disorders: a study of the Russian population of Siberia].
Ivanova et al., In Zh Nevrol Psikhiatr Im S S Korsakova, 2012
The phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) gene has been proposed as a putative susceptibility gene for schizophrenia on both positional and functional grounds.
Expression of PIP4K2A in lymphocyte cell lines from a sample of schizophrenia patients with previous evidence for association.
Schwab et al., In Schizophr Res, 2011
The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
Divecha et al., Manchester, United Kingdom. In Biochem J, 2010
PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha.
Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.
Bitter et al., Budapest, Hungary. In Am J Med Genet B Neuropsychiatr Genet, 2010
A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome.
Sørlie et al., Oslo, Norway. In Plos One, 2009
Studies indicate that the gene PIP5K2A was significantly elevated in stroma cells in distant metastasis group, compared to stroma in no distant metastasis group.
PIP4KIIA and beta-globin: transcripts differentially expressed in reticulocytes and associated with high levels of Hb H in two siblings with Hb H disease.
Sonati et al., Campinas, Brazil. In Eur J Haematol, 2009
PIP4KIIA may be one of the factors related to the regulation of the beta-globin gene expression and the different levels of Hb H in alpha-thalassemic patients
PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3.
Lang et al., Tübingen, Germany. In Psychopharmacology (berl), 2009
PIP5K2A is a novel signaling element in the regulation of EAAT3 activity
Association of PIP5K2A with schizophrenia: a study in an indonesian family sample.
Wildenauer et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2008
rs11013052 was significantly associated with schizophrenia in this Indonesian family sample
A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels.
Lang et al., Tübingen, Germany. In Psychopharmacologia, 2008
We find that wild-type PIP5K2A but not the schizophrenia-associated mutant (N251S)-PIP5K2A activates heteromeric KCNQ2/KCNQ3 and KCNQ3/KCNQ5, the molecular correlate of neuronal M channels.
Deciphering the lithium transcriptome: microarray profiling of lithium-modulated gene expression in human neuronal cells.
Parthasarathy et al., Louisville, United States. In Neuroscience, 2008
Differentially expressed genes associated with phosphoinositide metabolism include those encoding phosphatidyl inositol 4-phosphate 5-kinase type II alpha (PIP5K2A), WD repeat domain, phosphoinositide interacting 1 protein (WIPI49), tribbles homolog 3 (TRB3) and sorting nexin 14 (SNX14).
eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?
Carter, In Schizophr Bull, 2007
These include NMDA (GRIN1, GRIN2A, GRIN2B) and metabotropic (GRM3, GRM4) glutamate receptors, growth factors (BDNF, NRG1), and many of their downstream signaling components or accomplices (AKT1, DAO, DAOA, DISC1, DTNBP1, DPYSL2, IMPA2, NCAM1, NOS1, NOS1AP, PIK3C3, PIP5K2A, PDLIM5, RGS4, YWHAH).
The PIP5K2A gene and schizophrenia in the Chinese population--a case-control study.
He et al., Shanghai, China. In Schizophr Res, 2007
PIP5K2A gene is implicated in schizophrenia in Chinese population
The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia.
Sinke et al., Utrecht, Netherlands. In Genes Brain Behav, 2007
The strongest evidence for schizophrenia association was found for the A-allele of SNP rs10828317 in the PIP5K2A gene, which was associated with both clinical subtypes. This SNP leads to a change in protein composition.
Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability.
Carter, In Neurochem Int, 2007
Several form most of the components of a phosphatidyl-inositol signalling/AKT1 survival pathway (PIK3C3, PIP5K2A, PLCG1, SYNJ1, IMPA2, AKT1, GSK3B, TCF4) which is activated by growth factors (BDNF, NRG1) and also by NMDA receptors (GRIN1, GRIN2A, GRIN2B).
Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder.
Schumacher et al., Bonn, Germany. In Am J Med Genet B Neuropsychiatr Genet, 2006
Results from molecular and pharmacological studies point to involvement of the gene coding for the phosphatidylinositol-4-phosphate 5-kinase type II-alpha (PIP5K2A) in the development of schizophrenia and bipolar affective disorder (BPAD).
The phosphatidylinositol 4-phosphate 5-kinase family.
Anderson et al., Madison, United States. In Adv Enzyme Regul, 1995
The cloning of the first PIP5K, the PIP5KII alpha, is just the beginning of the molecular classification of this protein family.
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