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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma

Top mentioned proteins: KIF5B, A20, TNF Receptor-Associated Factor 1, CDK6, STAT4
Papers on PIP4K2C
Plasma Autoantibodies Associated with Basal-like Breast Cancers.
LaBaer et al., Warsaw, Poland. In Cancer Epidemiol Biomarkers Prev, Sep 2015
RESULTS: We identified 13 AAbs (CTAG1B, CTAG2, TP53, RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21) that distinguished BLBC from controls with 33% sensitivity and 98% specificity.
Replication of European rheumatoid arthritis loci in a Pakistani population.
Kamboh et al., Islamabad, Pakistan. In J Rheumatol, 2013
RESULTS: Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP.
Discovery of potent and selective covalent inhibitors of JNK.
Gray et al., Boston, United States. In Chem Biol, 2012
Potential lead compounds have also been identified for kinases, including IRAK1, PIK3C3, PIP4K2C, and PIP5K3.
Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population.
Siminovitch et al., Winnipeg, Canada. In Genes Immun, 2011
RA patients (n=333) and controls (n=490) from the Cree/Ojibway NAN population in Central Canada were HLA-DRB1 typed and tested for 21 single-nucleotide polymorphisms (SNPs) that have previously been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL.
Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population.
Xu et al., Brisbane, Australia. In Ann Rheum Dis, 2011
RESULTS: Robust association was detected for MMEL1 and CTLA4, and modest association was identified for another six loci: PADI4, STAT4, PRDM1, CDK6, TRAF1-C5 and KIF5A-PIP4K2C.
Genetic variants in the prediction of rheumatoid arthritis.
Huizinga et al., Leiden, Netherlands. In Ann Rheum Dis, 2010
The following genetic variants were assessed HLA-DRB1 shared epitope (SE) alleles, rs2476601 (PTPN22), rs108184088 (TRAF1-C5), rs7574865 (STAT4), rs3087243 (CTLA4), rs4810485 (CD40), rs1678542 (KIF5A-PIP4K2C), rs2812378 (CCL21), rs42041 (CDK6), rs4750316 (PRKCQ), rs6684865 (MMEL1-TNFRSF14), rs2004640 (IRF5), rs6920220 and rs10499194 (TNFAIP3-OLIG3), interactions between HLA-SE alleles and rs2476601 (PTPN22) and between HLA-SE alleles and smoking.
Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis.
Rovensk√Ĺ et al., Regensburg, Germany. In Ann N Y Acad Sci, 2010
Recent genome-wide association studies (GWAS) on RA identified known and novel susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C.
Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis.
Begovich et al., Alameda, United States. In Semin Immunol, 2009
Recently the results of multiple, well powered, genetic case-control studies have begun to appear providing convincing statistical evidence for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis.
Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.
Irvine et al., Cambridge, United Kingdom. In J Comp Neurol, 2009
our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain
Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
van der Helm-Van Mil et al., Leiden, Netherlands. In Arthritis Rheum, 2009
A recent meta-analysis of genome-wide association studies identified 6 genetic regions for susceptibility to autoantibody-positive RA: CD40, KIF5A/PIP4K2C, CDK6, CCL21, PRKCQ, and MMEL1/TNFRSF14.
New autoantigens in rheumatoid arthritis (RA): screening 8268 protein arrays with sera from patients with RA.
Roudier et al., Marseille, France. In Ann Rheum Dis, 2009
RESULTS: We identified four antigens (peptidyl arginine deiminase 4 (PAD4), protein kinase Cbeta1 (PKCbeta1), phosphatylinositol 4 phosphate 5 kinase type II gamma (PIP4K2C) and v raf murine sarcoma viral oncogene homologue B1 catalytic domain (BRAF)) that were recognised almost uniquely by sera from patients with RA on protein arrays.
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Todd et al., Cambridge, United Kingdom. In Genes Immun, 2009
In up to 8010 cases and 9733 controls we found some evidence for an association with T1D in the regions containing genes: 2q32/STAT4, 17q21/STAT3, 5p15/ERAP1 (ARTS1), 6q23/TNFAIP3 and 12q13/KIF5A/PIP4K2C with allelic P-values ranging from 3.70 x 10(-3) to 3.20 x 10(-5).
Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.
Irvine et al., Cambridge, United Kingdom. In Am J Physiol Renal Physiol, 2008
PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells.
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Plenge et al., Cambridge, United States. In Nat Genet, 2008
Finally, we identified evidence of association at four additional gene loci: MMEL1-TNFRSF14 (rs3890745, P = 0.0035 replication, P = 1.1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall).
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