GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Pim-1 oncogene
pim-1
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] (from
NCBI)
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Top mentioned proteins:
CAN, c-Myc, PIM2, kidney 1, HAD
Papers using
pim-1
antibodies
A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein
Supplier
In Oncogene, 2002
... Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc ...
Papers on
pim-1
The influence of few-layer graphene on the gas permeability of the high-free-volume polymer PIM-1.
New
Rende, Italy. In Philos Transact A Math Phys Eng Sci, Mar 2016
Gas permeability data are presented for mixed matrix membranes (MMMs) of few-layer graphene in the polymer of intrinsic microporosity PIM-1, and the results compared with previously reported data for two other nanofillers in PIM-1: multiwalled carbon nanotubes functionalized with poly(ethylene glycol) (f-MWCNTs) and fused silica.
Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biologic heterogeneity of the disease.
New
Boston, United States. In Blood, Feb 2016
Six of the eight DLBCL models were ABC-type tumors that exhibited ABC-associated mutations such as MYD88, CD79B, CARD11 and PIM1.
Microscopic Model of the Metal-Organic Framework/Polymer Interface: A First Step toward Understanding the Compatibility in Mixed Matrix Membranes.
New
Montpellier, France. In Acs Appl Mater Interfaces, Feb 2016
This was applied to the case of the composite formed by the polymer of intrinsic microporosity, PIM-1, and the zeolitic imidazolate framework, ZIF-8, as a model system.
Genomic characterization of primary central nervous system lymphoma.
New
Tokyo, Japan. In Acta Neuropathol, Feb 2016
We have now performed whole-exome sequencing for 41 tumor tissues of DLBCL-type PCNSL and paired normal specimens and also RNA-sequencing for 30 tumors, revealing a very high frequency of nonsynonymous somatic mutations in PIM1 (100 %), BTG2 (92.7 %), and MYD88 (85.4 %).
Clinical and biological significance of PIM1 kinase in osteosarcoma.
New
Wuhan, China. In J Orthop Res, Jan 2016
Proto-oncogene serine/threonine-protein kinase PIM1 is associated with growth and survival of many kinds of tumor cells.
MYC-mediated synthetic lethality for treatment of hematological malignancies.
Review
Wuhan, China. In Curr Cancer Drug Targets, 2014
Many small molecule inhibitors (SMIs) have been proven to induce MYC-SL by targeting AUK-B, Brd4, CDK1, CHK1, MCL-1, the mTOR/4E-BP1/eIF4E pathway, and PIM1/2.
PIM kinases: an overview in tumors and recent advances in pancreatic cancer.
Review
Beijing, China. In Future Oncol, 2014
The PIM kinases represent a family of serine/threonine kinases, which is composed of three different members (PIM1, PIM2 and PIM3).
Systems biology of primary CNS lymphoma: from genetic aberrations to modeling in mice.
Review
Köln, Germany. In Acta Neuropathol, 2014
On the genetic level, PCNSL are characterized by ongoing aberrant somatic hypermutation that, besides the IG locus, targets the PAX5, TTF, MYC, and PIM1 genes.
Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update.
Review
Bengaluru, India. In Expert Opin Ther Pat, 2014
INTRODUCTION: The proviral insertion in murine (PIM) lymphoma proteins for which three isoforms, PIM1, PIM2 and PIM3 have been identified, belonging to the family of serine/threonine kinases has emerged recently as an important therapeutic target for the development of selective inhibitors as the new drugs for treating hematological malignancies and solid tumors.
PIM1 kinase as a target in prostate cancer: roles in tumorigenesis, castration resistance, and docetaxel resistance.
Review
Nashville, United States. In Curr Cancer Drug Targets, 2013
PIM1 kinase is a serine/threonine kinase that has been shown to be overexpressed in multiple human malignancies, including prostate cancer.
Expression of proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is post-transcriptionally regulated by tristetraprolin in cancer cells.
GeneRIF
Ulsan, South Korea. In J Biol Chem, 2012
TTP post-transcriptionally down-regulates Pim-1 expression and that the overexpression of TTP may contribute to tumor suppression in part by down-regulating Pim-1 expression.
Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells.
GeneRIF
Zhanjiang, China. In Asian Pac J Trop Med, 2012
Findings suggest that Pim-1 overexpression contributes to nasopharyngeal carcinoma (NPC) proliferation and migration, and targeting Pim-1 may be a potential treatment for anti-Pim-1-expressed NPCs.
Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.
GeneRIF
Madison, United States. In Proc Natl Acad Sci U S A, 2012
results suggest that modulation of the degradation of Isu by the Pim1 protease is a regulatory mechanism serving to rapidly help balance the cell's need for critical iron-requiring processes under changing environmental conditions
Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells.
GeneRIF
San Diego, United States. In Circ Res, 2012
Genetic modification of bone marrow cells with Pim-1 may serve as a therapeutic approach to promote recovery of myocardial structure in myocardial infarction.
PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling.
GeneRIF
Salzburg, Austria. In Bmc Mol Biol, 2011
The C-terminus of human PIM-1 kinase isoform2, a serine/threonine kinase of the calcium/calmodulin-regulated kinase family, directly interacts with VDR through the receptor's DNA-binding domain.
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.
Impact
Columbus, United States. In Cell, 2010
Restoration of miR-328 expression rescues differentiation and impairs survival of leukemic blasts by simultaneously interacting with the translational regulator poly(rC)-binding protein hnRNP E2 and with the mRNA encoding the survival factor PIM1, respectively.
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
Impact
Siena, Italy. In Cell, 2009
Serum stimulation induces the PIM1 kinase to phosphorylate the preacetylated histone H3 at the FOSL1 enhancer.
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
Impact
GeneRIF
Siena, Italy. In Nat Cell Biol, 2007
Results establish a new function for PIM1 as a MYC cofactor that phosphorylates the chromatin at MYC-target loci and suggest that nucleosome phosphorylation, at E boxes, contributes to MYC-dependent transcriptional activation and cellular transformation.
Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.
Impact
London, United Kingdom. In Nature, 2007
The Ran-deficient pim1 mutant (pim1-F201S) failed to show mitosis-specific nuclear accumulation of Alp7.
Gene expression profile predicts patient survival of gastric cancer after surgical resection.
Impact
Taipei, Taiwan. In J Clin Oncol, 2005
RESULTS: A survival prediction model consisting of three genes (CD36, SLAM, PIM-1) was developed.
