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Paired immunoglobin-like type 2 receptor beta

PILRB, paired immunoglobulin-like receptor-B, Pilrb1, paired immunoglobin-like receptor B
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq, Aug 2010] (from NCBI)
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Top mentioned proteins: POLYMERASE, IL-10, PIR, CD99, HLA-G
Papers on PILRB
Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia.
Wang et al., Xi'an, China. In Brain Inj, 2012
PRIMARY OBJECTIVE: Paired immunoglobulin-like receptor-B (PirB) is another receptor, except for the Nogo receptor, that is involved in inhibition of axons regeneration after central nervous system injury.
The myeloid receptor PILR╬▓ mediates the balance of inflammatory responses through regulation of IL-27 production.
Cua et al., Palo Alto, United States. In Plos One, 2011
Data show that PILRbeta is important for regulating aberrant inflammatory responses through IL-27 production.
Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17.
Rouas-Freiss et al., Paris, France. In Blood, 2011
In the present study, we provide the first in vivo evidence of such a role by a xenotumor model in mice based on the interactions between human HLA-G and the murine paired immunoglobulin-like receptor-B (PIR-B).
Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
Takayanagi et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2010
The inhibitory effect of Ly49Q-deficiency may be explained by the finding that Ly49Q competed for the association of Src-homology domain-2 phosphatase-1 (SHP-1) with paired immunoglobulin-like receptor-B (PIR-B), an ITIM-bearing receptor which negatively regulates osteoclast differentiation.
Modulation of paired immunoglobulin-like type 2 receptor signaling alters the host response to Staphylococcus aureus-induced pneumonia.
Heyworth et al., Palo Alto, United States. In Infect Immun, 2010
Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.
[Study of paired immunoglobin-like receptor B expression on dendritic cells and its relationship with immune tolerance in mouse].
Zou et al., Wuhan, China. In Zhonghua Xue Ye Xue Za Zhi, 2007
OBJECTIVE: To investigate the expression of paired immunoglobin-like receptor B (PIR-B) on dendritic cells (DCs) and its relationship with tolerogenic DCs (T-DCs) in mouse.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
Within the BCR-ABL-positive subgroups, we identified genes overexpressed (PILRB, STS-1, SPRY1) or underexpressed (TSPAN16, ADAMTSL4) in p185BCR-ABL-positive ALL relative to p210BCR-ABL-positive ALL.
Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.
Koop et al., Victoria, Canada. In Physiol Genomics, 2006
The paired immunoglobulin-like receptor (PILR) locus at 7q22 encodes both PILRA, an inhibitory receptor, and PILRB, its activating counterpart.
Gene expression profiling of human erythroid progenitors by micro-serial analysis of gene expression.
Sawada et al., Akita, Japan. In Int J Hematol, 2004
Erythroid progenitor cells showed increased expression of LRBA, EEF1A1, HSPCA, PILRB, RANBP1, NACA, and SMURF.
Mobilizing dendritic cells for tolerance by engagement of immune inhibitory receptors for HLA-G.
Horuzsko et al., Augusta, United States. In Hum Immunol, 2003
We show that the triggering of the murine inhibitory receptor paired immunoglobulin-like receptor-B by cross-linking or by human leukocyte antigen (HLA)-G tetramer resulted in the modulation of DC function and prolongation of allogeneic graft survival.
FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.
Garrone et al., France. In J Immunol, 2000
Characterization of paired counterpart PILRA.
NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1.
Dissen et al., Oslo, Norway. In Eur J Immunol, 1999
NILR-1 shows greatest sequence homology to the mouse paired immunoglobulin-like receptor-B and members of the human leukocyte immunoglobulin-like receptor/immunoglobulin-like transcript group of receptors.
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