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Phosphoinositide-3-kinase, class 2, gamma polypeptide

PIK3C2G, PI3K-C2gamma
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PI3K, AGE, p53, TOP, Insulin
Papers on PIK3C2G
Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients.
Guglielmi et al., Verona, Italy. In Ann Surg Oncol, Jan 2016
The presence of mutations in ARID1A, PIK3C2G, STK11, TGFBR2, and TP53 genes was significantly associated with poor prognosis in patients with ICC (p = 0.012, p = 0.030, p = 0.030, p = 0.011, and p = 0.011, respectively).
Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population.
Yang et al., Beijing, China. In Bmc Genomics, 2014
Ultimately, two missense SNPs in GGA1 and one in GGA4 were considered as promising loci on three independent genes including ITPR2, PIK3C2G, and NCAPG.
PIK3C2G copy number is associated with clinical outcomes of colorectal cancer patients treated with oxaliplatin.
Yin et al., Shanghai, China. In Int J Clin Exp Med, 2014
PURPOSE: To investigate whether the copy number of PIK3C2G is associated with clinical outcomes for stage III colorectal cancer (CRC) patients treated with oxaliplatin-based chemotherapy.
First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes.
Blackwell et al., Australia. In Plos One, 2014
PIK3C2G (rs12816270 Pgenotyped = 8.06x10-6; rs10841048 Pimputed_1000G = 6.28x10-7) was associated with BMI, but not with T2D as reported elsewhere.
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
Li et al., Chengdu, China. In Plos One, 2012
SNPs from three genes or chromosomal regions (TBXAS1, PIK3C2G and HS3ST5) were identified to predict the changes of GM volume in hOC3vL, vermisL10 and vermisR10.
Genetic copy number variants in myocardial infarction patients with hyperlipidemia.
Hsu et al., Taiwan. In Bmc Genomics, 2011
(PIK3C2G) and 16q23.3
Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells.
Dai et al., Amarillo, United States. In Leuk Lymphoma, 2010
Comparison of the gene expression profiles among parental Ba/F3 cells and cells transformed by p185(Bcr-Abl) and p185(Delta176-426) reveals that class II phosphoinositide 3-kinase gamma (PI3KC2gamma) expression is markedly down-regulated by p185(Bcr-Abl) but not p185(Delta176-426).
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma.
Xiong et al., Shanghai, China. In Bmc Syst Biol, 2009
We identified 4 cis-expression quantitative trait locus (eQTL): TP53, EGFR, NF1 and PIK3C2G; 262 trans eQTL and 26 trans miRNA eQTL for somatic mutation; 2 cis-eQTL: NRAP and EGFR; 409 trans- eQTL and 27 trans- miRNA eQTL for lost of heterozygosity (LOH) mutation.
An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.
Sinke et al., Utrecht, Netherlands. In Mol Psychiatry, 2008
We also report weak association of SNPs in PIK3C2G, FGF1, FGFR1, ARHGEF10 and PSAP (observed P<or=0.01).
Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population.
Kato et al., Yamagata, Japan. In Biochem Biophys Res Commun, 2008
The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined.
Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.
Persaud et al., London, United Kingdom. In Diabetes, 2006
The detection of mRNAs for insulin receptor (IR)A and IRB; insulin receptor substrate (IRS)-1 and IRS-2; phosphoinositide 3-kinase (PI3K) catalytic subunits p110alpha, p110beta, PI3KC2alpha, and PI3KC2gamma; phosphoinositide-dependent protein kinase-1; protein kinase B (PKB)alpha, PKBbeta, and PKBgamma in the beta-cell population suggests the presence of a functional insulin signaling cascade in human beta-cells.
Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?
Fry et al., Reading, United Kingdom. In Bull Cancer, 2006
Of the three classes of true phosphoinositide (PI) 3-kinases, the class II subdivision, which consists of three isoforms, PI3K-C2alpha, PI3K-C2beta and PI3K-C2gamma, is the least well understood.
Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly.
Debiec-Rychter et al., Leuven, Belgium. In Cancer Genet Cytogenet, 2006
Multicolor fluorescence in situ hybridization (M-FISH), followed by conventional FISH analysis, confirmed the reciprocal translocation as the sole cytogenetic anomaly, and allowed for the positioning of chromosomes 12 and 19 breakpoints proximal to the BCL3 gene and between ETV6 and PIK3C2G gene loci, respectively.
Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization.
Tomlinson et al., London, United Kingdom. In J Pathol, 2005
Other potential oncogenes, which mapped to regions found by this study, included cyclin E and PIK3C2G.
Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.
Lalani et al., London, United Kingdom. In Bmc Clin Pathol, 2003
The PI3K enzyme family is divided into 3 classes; class I (subdivided into IA and IB), class II (PI3K-C2alpha, PI3K-C2beta and PI3K-C2gamma) and class III PI3K.
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