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Excision repair cross-complementing rodent repair deficiency, complementation group 6-like

PICH, Plk1-interacting checkpoint helicase
Top mentioned proteins: Plk1, AGE, POLYMERASE, ATPase, Blm
Papers on PICH
Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability.
van Vugt et al., Utrecht, Netherlands. In Dev Cell, Sep 2015
Sister-chromatid disjunction in anaphase requires the resolution of DNA catenanes by topoisomerase II together with Plk1-interacting checkpoint helicase (PICH) and Bloom's helicase (BLM).
SUMOylation regulates polo-like kinase 1-interacting checkpoint helicase (PICH) during mitosis.
Azuma et al., Lawrence, United States. In J Biol Chem, Mar 2015
We identified Polo-like kinase 1-interacting checkpoint helicase (PICH) as an interaction partner of SUMOylated PARP1 in Xenopus egg extract.
Rice SNF2 family helicase ENL1 is essential for syncytial endosperm development.
Hattori et al., Nagoya, Japan. In Plant J, 2015
The molecular identification of the causal gene revealed that ENL1 encodes an SNF2 helicase family protein that is orthologous to human Plk1-Interacting Checkpoint Helicase (PICH), which has been implicated in the resolution of persistent DNA catenation during anaphase.
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.
Hickson et al., Copenhagen, Denmark. In Nat Commun, 2014
PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis.
Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis.
You et al., Chengdu, China. In Med Sci Monit, 2014
RESULTS: Similar genotype distribution was detected between PICH patients and healthy controls (p=0.523).
Association between warfarin combined with serotonin-modulating antidepressants and increased case fatality in primary intracerebral hemorrhage: a population-based study.
Hillbom et al., In J Neurosurg, 2014
Serotonin-modulating antidepressants (selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs]) are frequently used in combination with warfarin, but it is unclear whether this combination of drugs influences outcome after primary intracerebral hemorrhage (PICH).
Genetic polymorphism of LDLR (rs688) is associated with primary intracerebral hemorrhage.
Pan et al., Taiwan. In Curr Neurovasc Res, 2014
The current study aimed to investigate the potential role of rs688 in primary intracerebral hemorrhage (PICH).
Mitotic catenation is monitored and resolved by a PKCε-regulated pathway.
Parker et al., London, United Kingdom. In Nat Commun, 2013
When delayed by catenation in mitosis, inhibition of PKCε results in premature entry into anaphase with PICH-positive strands and chromosome bridging.
The AGTR1 gene A1166C polymorphism as a risk factor and outcome predictor of primary intracerebral and aneurysmal subarachnoid hemorrhages.
Pera et al., Kraków, Poland. In Neurol Neurochir Pol, 2013
We aimed to investigate the role of this polymorphism as risk factors and outcome predictors in primary intracerebral hemorrhage (PICH) and aneurysmal subarachnoid hemorrhage (aSAH).
PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.
Hickson et al., Amsterdam, Netherlands. In Mol Cell, 2013
The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFBs) in mitosis alongside a complex of DNA repair proteins, including the Bloom's syndrome protein (BLM).
Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase.
Amor-Guéret et al., Orsay, France. In Plos One, 2011
PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process.
New insights into the formation and resolution of ultra-fine anaphase bridges.
Hickson et al., Oxford, United Kingdom. In Semin Cell Dev Biol, 2011
These UFBs are also defined by the presence of a SNF2 family protein called PICH.
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.
Yu et al., Dallas, United States. In Embo J, 2011
PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.
PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture.
Yu-Lee et al., Houston, United States. In Mol Biol Cell, 2010
the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture
Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
Nigg et al., München, Germany. In Chromosoma, 2010
the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein.
Cerebral amyloid angiopathy: a common cause of cerebral hemorrhage.
Padovani et al., Brescia, Italy. In Curr Med Chem, 2008
The spectrum of clinical phenotypes associated with CAA-related vasculopathic changes includes both ischemic and hemorrhagic presentations, primary intracerebral hemorrhage (PICH) being probably the most well-recognized.
Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase.
Qin et al., Houston, United States. In Cell Cycle, 2008
PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms.
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
Nigg et al., Martinsried, Germany. In Cell, 2007
These data identify PICH as a novel essential component of checkpoint signaling.
Polo delivers a PICH to the kinetochore.
Yen, Philadelphia, United States. In Cell, 2007
In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase.
Implication of ATP receptors in brain functions.
Ueno et al., Tokyo, Japan. In Prog Neurobiol, 1996
Moreover, mRNAs for certain types of P2x-purinoceptors are present in the hippocampus [Collo, G., North, R. A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A. and Buell, G. (1996) J. Neurosci.
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