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Enolase 1,

Phosphopyruvate Hydratase, alpha-enolase
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: fibrillin-1, ACID, Phosphogluconate Dehydrogenase, CAN, Plasminogen
Papers on Phosphopyruvate Hydratase
Protein expression in the brain of rat offspring in relation to prenatal caloric restriction.
Chrousos et al., Athens, Greece. In J Matern Fetal Neonatal Med, Nov 2015
RESULTS: 14-3-3 Protein, calreticulin, elongation factor, alpha-enolase, fascin, heat-shock protein HSP90 and pyruvate kinase isozymes were significantly increased (p < 0.05) in samples obtained from IUGR newborn pups compared to non-IUGR.
Comparative analysis of extractable proteins from Clostridium perfringens type A and type C strains showing varying degree of virulence.
Kumar et al., Gwalior, India. In Anaerobe, Oct 2015
Significant among the differentially expressed proteins were elongation factor, molecular chaperones, ribosomal proteins, carbamoyl phosphate synthase, clpB protein, choloylglycine hydrolase, phosphopyruvate hydratase, and trigger factor.
Effect of prolonged exposure to sublethal concentrations of DDT and DDE on protein expression in human pancreatic beta cells.
Kovar et al., Praha, Czech Republic. In Environ Res, Oct 2015
With these techniques, four proteins were found downregulated after exposure to 10 μM DDT: three cytoskeletal proteins (cytokeratin 8, cytokeratin 18 and actin) and one protein involved in glycolysis (alpha-enolase).
Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation.
Novelli et al., Torino, Italy. In Immunol Lett, Sep 2015
In PDAC patients, alpha-enolase (ENOA), a glycolytic enzyme that also acts as plasminogen receptor, is up-regulated and elicits the production of autoantibodies.
Alpha-enolase is a potential prognostic marker in clear cell renal cell carcinoma.
Yousef et al., Toronto, Canada. In Clin Exp Metastasis, Aug 2015
We assessed the expression of alpha-enolase (ENO1) protein by immunohistochemistry in 360 patients with primary ccRCC and correlated its expression with multiple clinicopathological parameters including stage, grade, tumor size, disease-free and overall survival.
Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.
Giallongo et al., Palermo, Italy. In Febs Lett, Aug 2015
Myc promoter-binding protein-1 (MBP-1) is a shorter protein variant of the glycolytic enzyme alpha-enolase.
Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage.
Ni et al., Shenzhen, China. In J Proteomics, Jul 2015
Among them, alpha-enolase (ENO1) and glutamine synthetase (GS) were identified as the common targets of oxidation in the brains of 3 × Tg-AD mice, mild cognitive impairment (MCI) sufferers and AD patients.
A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells.
Møller et al., New York City, United States. In Plos One, 2014
Several of the proteins are associated with neuronal processes, including peroxiredoxin-2 and -4, cofilin-1, prefoldin 2, alpha-enolase, human nucleoside diphosphate kinase B (Nm23) and 14-3-3 protein epsilon.
Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model.
Vittecoq et al., Rouen, France. In Plos One, 2014
OBJECTIVE: To evaluate the ability of the glycolytic enzyme alpha-enolase (ENO1) or its immunodominant peptide (pEP1) to reduce the severity of CIA in DBA/1 mice when injected in a prophylactic way.
Diagnosis and classification of autoimmune hypophysitis.
Gerli et al., Italy. In Autoimmun Rev, 2014
Among the target autoantigens recognized by APA are alpha-enolase, gamma-enolase, the pituitary gland specific factors (PGSF) 1 and 2 and corticotroph-specific transcription factor (TPIT).
[The biomarker and treatment in Hashimoto's encephalopahty].
Yoneda et al., Fukui, Japan. In Nihon Rinsho, 2013
We recently discovered the serum autoantibodies (Abs) against the NH2-terminal of alpha-enolase (NAE) as a diagnostic biomarker for HE.
Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis.
Mahler et al., Leiden, Netherlands. In Autoimmun Rev, 2012
During the last decades, several autoantigens have been described in RA including Ra33 (hnRNP A2), fibrinogen, fibronectin, alpha-enolase, type II collagen, immunoglobulin binding protein (BiP), annexins and viral citrullinated peptide (VCP) derived from Epstein Barr Virus-encoded protein (EBNA-2).
[Membranous glomerulonephritis--recent advances in pathogenesis and treatment].
Galesić et al., Dubrovnik, Croatia. In Lijec Vjesn, 2012
In recent years, first human podocyte autoantigens, responsible for autoantibodies and in situ immune complexes formation, were discovered: neutral endopeptidase, m-type phospholipase A2 receptor, superoxide-dismutase 2, aldose-reductase, alpha-enolase.
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.
Choi et al., Anyang, South Korea. In Biochem J, 2012
Increased citrullination of Arg9 in ENO1 is associated with Creutzfeldt-Jakob disease and Alzheimer's disease.
α-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis.
Lee et al., Seoul, South Korea. In J Immunol, 2012
ENO1-positive monocytes and macrophages are found in arthritic ankle tissues of mice with collagen-induced arthritis.
Proteomics-based identification of α-enolase as a potential prognostic marker in cholangiocarcinoma.
Sripa et al., Khon Kaen, Thailand. In Clin Biochem, 2012
Data suggest that alpha-enolase (ENO1) may serve as a prognostic marker to monitor the disease progression of these patients.
Proinsulin C-peptide activates α-enolase: implications for C-peptide--cell membrane interaction.
Kimura et al., Sapporo, Japan. In J Biochem, 2012
results indicate that C-peptide has the capacity to activate alpha-enolase through a specific interaction between E27 of the peptide and K434 of the enzyme
Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity.
Peral et al., Madrid, Spain. In Plos One, 2011
Data show that ENOA, PARK7 and Beta-actin are proper reference standards in obesity studies based on omental fat.
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
Venables et al., London, United Kingdom. In Immunol Rev, 2010
Four citrullinated antigens, fibrinogen, vimentin, collagen type II, and alpha-enolase, are now well established, with others awaiting further characterization.
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
Lundberg et al., Stockholm, Sweden. In Nat Genet, 2009
Here, we test the hypothesis that a subset of the anti-CCP response, with specific autoimmunity to citrullinated alpha-enolase, accounts for an important portion of these associations.
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