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Glutathione peroxidase 4

phospholipid hydroperoxide glutathione peroxidase, PHGPx, GPX4, glutathione peroxidase 4
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, proteins are produced that localize to the nucleus, mitochondrion, and cytoplasm. The exact cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Ethanolaminephosphotransferase, gpx1, CAN, HAD
Papers on phospholipid hydroperoxide glutathione peroxidase
Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.
Rayman et al., Shenyang, China. In Am J Clin Nutr, Jan 2016
In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase (GPx4)].
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.
Ozanne et al., Cambridge, United Kingdom. In Faseb J, Jan 2016
Maternal obesogenic diet was associated with increased mitochondrial DNA biogenesis (copy number P < 0.05; transcription factor A, mitochondrial expression P < 0.05), increased mitochondrial antioxidant defenses [manganese superoxide dismutase (MnSOD) P < 0.05; copper/zinc superoxide dismutase P < 0.05; glutathione peroxidase 4 P < 0.01] and increased lipoxygenase expression (arachidonate 12-lipoxygenase P < 0.05; arachidonate 15-lipoxygenase P < 0.05) in the ovary.
Novel ferroptosis inhibitors with improved potency and ADME properties.
Augustyns et al., In J Med Chem, Jan 2016
UNASSIGNED: Ferroptosis is a non-apoptotic, iron-catalysed form of regulated necrosis that is critically dependent on glutathione peroxidase 4 (GPX4).
Ferroptosis: Death by Lipid Peroxidation.
Stockwell et al., New York City, United States. In Trends Cell Biol, Jan 2016
UNASSIGNED: Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides.
Influence of SkQ1 on Expression of Nrf2 Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes under Oxidative Stress.
Makarenko et al., Rostov-na-Donu, Russia. In Biochemistry (mosc), Dec 2015
The changes in gene expression profiles under hyperoxia were accompanied by disbalance of activity of antioxidant enzymes in the leukocytes, namely activation of superoxide dismutase and inhibition of catalase, glutathione peroxidase, and glutathione-S-transferase. Pretreatment of rats with SkQ1 (50 nmol/kg for five days) significantly increased mRNA levels of transcription factor Nrf2 and Nrf2-induced genes encoding antioxidant enzymes SOD2 and GPx4 and normalized the transcriptional activity of the SOD1 and CAT genes in the leukocytes in hyperoxia-induced oxidative stress.
Elucidating Compound Mechanism of Action by Network Perturbation Analysis.
Califano et al., New York City, United States. In Cell, Aug 2015
Finally, unknown-MoA compound analysis revealed altretamine, an anticancer drug, as an inhibitor of glutathione peroxidase 4 lipid repair activity, which was experimentally confirmed, thus revealing unexpected similarity to the activity of sulfasalazine.
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Conrad et al., München, Germany. In Nat Cell Biol, 2014
Here, we provide direct genetic evidence that the knockout of glutathione peroxidase 4 (Gpx4) causes cell death in a pathologically relevant form of ferroptosis.
Moonlighting proteins in sperm-egg interactions.
Auer et al., In Biochem Soc Trans, 2014
We identified proteins already described in human spermatozoa, but implicated in different metabolic pathways such as glycolytic enzymes [phosphokinase type 3 (PK3), enolase 1 (ENO1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), aldolase A (ALDOA) and triose phosphate isomerase (TPI)], detoxification enzymes [GST Mu (GSTM) and phospholipid hydroperoxide glutathione peroxidase (PHGPx) 4], ion channels [voltage-dependent anion channel 2 (VDAC2)] or structural proteins (outer dense fibre 2).
GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.
Costantini et al., Al Qubbah, Libya. In Eur J Histochem, 2014
In this paper we have evaluated the GPX4 and GPX7 expression in some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC by immunohistochemistry and RT-qPCR analysis.
Redox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stress.
Imai et al., Yamagata, Japan. In Spermatogenesis, 2014
During recent sulfoxidase research, GPX4 has emerged as a promising enzyme that plays essential roles in the production of fertile sperm, but the involvement of other redox proteins is also becoming evident.
Regulation of ferroptotic cancer cell death by GPX4.
Stockwell et al., United States. In Cell, 2014
We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds and a chemoproteomics strategy to discover that GPX4 is directly inhibited by a second class of compounds.
Roles of reactive oxygen species in the spermatogenesis regulation.
Ciarcia et al., Napoli, Italy. In Front Endocrinol (lausanne), 2013
It also deals with of the advantages of the system biology for an antioxidant under steroid control, the major selenoprotein expressed by germ cells in the testis, the phospholipid hydroperoxide glutathione peroxidase (PHGPx/GPx4) having multiple functions and representing the pivotal link between selenium, sperm quality, and species preservation.
[Polymorphisms in the oxidative stress-related genes and cancer risk].
Bober et al., In Ann Acad Med Stetin, 2012
In this review we focus on the biological function of antioxidant defence enzymes, and relationship between well-known SNPs in SOD1, SOD2, CAT, GPX1 and GPX4 genes and genetic susceptibility to cancer.
Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.
Ran et al., San Antonio, United States. In Free Radic Biol Med, 2012
Tam treatment also significantly elevated apoptosis in Gpx4(f/f)/Cre mice. Moreover, tam-treated Gpx4(f/f)/Cre mice showed neuronal loss in the hippocampus region and had increased astrogliosis
The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.
Solodilova et al., Kursk, Russia. In Hypertens Res, 2012
It was shown for the first time that the C718T polymorphism in the 3'-untranslated region of the GPX4 gene could be considered as a genetic marker of susceptibility to cerebral stroke in patients with essential hypertension.
Involvement of PKCα-MAPK/ERK-phospholipase A(2) pathway in the Escherichia coli invasion of brain microvascular endothelial cells.
Lupo et al., Catania, Italy. In Neurosci Lett, 2012
study demonstrated involvement of cytosolic and calcium-independent phospholipase A(2) and the contribution of cyclooxygenase-2 products in E. coli invasion of brain microvascular endothelial cells
Glutathione peroxidase 4 is required for maturation of photoreceptor cells.
Yanagi et al., Tokyo, Japan. In J Biol Chem, 2012
GPx4 is a critical antioxidant enzyme for the maturation and survival of photoreceptor cells.
SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease.
Xiong et al., Xi'an, China. In Br J Nutr, 2012
genetic association studies in a Han Chinese population in Shaanxi province: Data indicate that 2 SNP in GPx4 (rs713041, rs4807542) and down-regulation of expression of GPx4 mRNA may be related to development of Kashin-Beck disease.
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Conrad et al., München, Germany. In Cell Metab, 2008
Neuron-specific GPx4 depletion caused neurodegeneration in vivo and ex vivo, highlighting the importance of this pathway in neuronal cells.
Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.
Pharoah et al., Cambridge, United Kingdom. In J Clin Oncol, 2007
These data provide strong support for the hypothesis that common variation in GPX4 is associated with prognosis after a diagnosis of breast cancer.
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