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Phosphofructokinase, platelet

Phosphofructokinase-1, phosphofructokinase
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, Hexokinase, CAN, HAD, V1a
Papers on Phosphofructokinase-1
3-Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth.
Lu et al., Nanning, China. In Oncol Rep, Jan 2016
3-BrPA significantly reduced the glycolytic enzyme hexokinase activity, while SCT selectively inhibited phosphofructokinase-1 activity.
Dynamics and regulation of glycolysis-tricarboxylic acid metabolism in the midgut of Spodoptera litura during metamorphosis.
Feng et al., Guangzhou, China. In Insect Mol Biol, Jan 2016
The expression patterns of these genes in response to starvation were examined, and the interaction between protein phosphatase 1 (PP1) and phosphofructokinase (PFK) was studied.
NaCl stress impact on the key enzymes in glycolysis from Lactobacillus bulgaricus during freeze-drying.
Liu et al., Harbin, China. In Braz J Microbiol, Dec 2015
The activities of glycolytic enzymes (phosphofructokinase, pyruvate kinase, and lactate dehydrogenase) decreased during freeze-drying, and NaCl stress were found to improve activities of these enzymes before and after freeze-drying.
CO-CBS-H2 S axis: From vascular mediator to cancer regulator.
Kabe et al., Tokyo, Japan. In Microcirculation, Dec 2015
We have recently uncovered that stress-inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of 6-phosphofructo-2-kinase/fructose-2,6-bis-phosphatase 3 (PFKFB3), the enzyme regulating phosphofructokinase-1 (PFK-1), leading to a shift of glucose biotransformation from glycolysis towards pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress conditions for cancer cells.
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.
Barber et al., San Francisco, United States. In Nature, Aug 2015
Phosphofructokinase-1 (PFK1), the 'gatekeeper' of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over ten metabolites and in response to hormonal signalling fine-tune glycolytic flux to meet energy requirements.
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
Icard et al., Caen, France. In Oncogene, Jul 2015
HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-3-phosphate dehydrogenase activate survival pathways (Akt and so on); phosphofructokinase 1 and triose phosphate isomerase participate in cell cycle activation; aldolase promotes epithelial mesenchymal transition; PKM2 enhances various nuclear effects such as transcription, stabilisation and so on.
Efficient use of energy in anoxia-tolerant plants with focus on germinating rice seedlings.
Colmer et al., Sydney, Australia. In New Phytol, Apr 2015
growing) cells, PPi produced during substantial polymer synthesis allows conversion of PPi to ATP by PPi -phosphofructokinase (PFK).
Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy.
Zhou et al., Tianjin, China. In Thorac Cancer, 2015
The three key enzymes of glycolysis are hexokinase, phosphofructokinase, and pyruvate kinase.
Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes.
Nakagawa et al., Kyoto, Japan. In Sci Rep, 2014
Finally, adult mouse podocytes have most of mitochondria predominantly in the center of the cytosol whereas phosphofructokinase, a rate limiting enzyme for glycolysis, was expressed in foot processes.
T-cell metabolism in autoimmune disease.
Weyand et al., Stanford, United States. In Arthritis Res Ther, 2014
This anti-Warburg effect results from insufficient activity of the glycolytic enzyme phosphofructokinase and differentiates the metabolic status in RA T cells from those in cancer cells.
Antifatigue Activity of Liquid Cultured Tricholoma matsutake Mycelium Partially via Regulation of Antioxidant Pathway in Mouse.
Teng et al., Changchun, China. In Biomed Res Int, 2014
Further data obtained from western blot show that CM and ABM have strongly enhanced the activation of 5'-AMP-activated protein kinase (AMPK), and the expressions of peroxisome proliferator have activated receptor γ coactivator-1α (PGC-1α) and phosphofructokinase-1 (PFK-1) in liver.
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Carmeliet et al., Leuven, Belgium. In Cell Metab, 2014
We recently provided genetic evidence that the glycolytic activator phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) promotes vessel formation but did not explore the antiangiogenic therapeutic potential of PFKFB3 blockade.
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Hsieh-Wilson et al., Pasadena, United States. In Science, 2012
O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia.
Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer.
Kim et al., Seoul, South Korea. In J Biol Chem, 2011
KLF4 plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells.
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.
Hansen et al., Copenhagen, Denmark. In Plos One, 2007
PFKP polymorphisms play no apparent role in the development of common forms of obesity in the Danish population.
Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites.
Aragón et al., Madrid, Spain. In Febs Lett, 2007
Two phosphofructokinase (PFK) chimeras were constructed by exchanging the N- and C-terminal halves of the mammalian M- and C-type isozymes.
Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines.
Bigl et al., Leipzig, Germany. In Gene, 2005
The transcription start point was determined at 48 bp upstream of the start codon. the region -65 to +48 turned out to be sufficient for promoter activity
The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.
Kang et al., Seoul, South Korea. In Nat Biotechnol, 2005
The genome lacks recognizable genes for 6-phosphofructokinase, an essential enzyme in the Embden-Meyerhof-Parnas pathway, and for two enzymes in the tricarboxylic acid cycle, the 2-oxoglutarate dehydrogenase complex and malate dehydrogenase, so glucose can be metabolized only by the Entner-Doudoroff pathway.
Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes.
Cravatt et al., Los Angeles, United States. In Mol Cell Proteomics, 2002
PFKP was identified using a trifunctional phenyl sulfonate probe.
Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts.
Silvestre et al., In Nature, 1980
To determine whether the rapid activation of phosphofructokinase--and therefore glycolysis--by purified growth factors is necessary for the initiation of cell proliferation, we have isolated and studied two classes of glycolytic mutants.
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