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PHD finger protein 2

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, demethylase, Jumonji, HAD, POLYMERASE
Papers on PHF2
Identification of family-determining residues in Jumonji-C lysine demethylases: A sequence-based, family-wide classification.
Slama, Paris, France. In Proteins, Feb 2016
Implications of family conditions are studied in detail on PHF2, revealing the meaningfulness of the sequence-derived conditions at the structural level.
Reader interactome of epigenetic histone marks in birds.
Butter et al., Mainz, Germany. In Proteomics, Jan 2016
In agreement with their epigenetic role, we find binding of PHF2 and members of the TFIID, SAGA, SET1 and NURF complex to the activation mark H3K4me3.
Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.
Katoh, Tokyo, Japan. In Expert Rev Proteomics, Jun 2015
Phylogenetic analyses of 139 human PHD fingers revealed that ASXL PHD fingers cluster with those of BPTF, DIDO, ING1, KDM5A (JARID1A), KMT2E (MLL5), PHF2, PHF8 and PHF23.
PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer.
Chun et al., Seoul, South Korea. In Oncogene, Jun 2015
Plant homeodomain finger 2 (PHF2) has a role in epigenetic regulation of gene expression by demethylating H3K9-Me2.
The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C/EBPα and C/EBPδ.
Chun et al., Seoul, South Korea. In Mol Cells, 2014
Plant homeodomain finger 2 (PHF2) is a Jumonji domain-containing protein and is known to demethylate the histone H3K9, a repressive gene marker.
PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.
Wong et al., Shanghai, China. In J Biol Chem, 2014
PHF2 and PHF8 belong to a subfamily of histone demethylases that also possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus.
Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation.
Chun et al., Seoul, South Korea. In Cell Res, 2014
Plant homeodomain finger protein 2 (PHF2), which contains a plant homeodomain and a Jumonji-C domain, is an epigenetic regulator that demethylates lysine 9 in histone 3 (H3K9me2).
Epigenetic regulation of adipogenesis by PHF2 histone demethylase.
Imai et al., Tokyo, Japan. In Diabetes, 2013
PHF2 is a JmjC family histone demethylase that removes the methyl group from H3K9me2 and works as a coactivator for several metabolism-related transcription factors.
Inactivation of 9q22.3 tumor suppressor genes predict outcome for patients with head and neck squamous cell carcinoma.
Panda et al., Calcutta, India. In Anticancer Res, 2013
AIM: This study examined the prognostic significance of candidate tumor suppressor genes (TSGs) PHD finger protein-2 (PHF2), Fanconi anaemia complementation group C (FANCC) and human homologue of Drosophila patched gene (PTCH1), in head and neck squamous cell carcinoma (HNSCC) treated primarily with surgery, or surgery followed by adjuvant radiotherapy.
Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.
Xu et al., Shantou, China. In Acta Histochem, 2013
Jumonji AT-rich interactive domain 1B (JARID1B) and PHD finger protein 2 (PHF2), members of the histone demethylases, have been found to be involved in many types of tumors.
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.
Glass et al., San Diego, United States. In Mol Cell, 2012
Signal-dependent erasure of H4K20me3 is required for effective gene activation and is achieved by NF-κB-dependent delivery of the histone demethylase PHF2.
PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
Zeng et al., Johnson City, United States. In J Mol Neurosci, 2012
The third locus was PHF2 at 9q22.31 (the top SNP was rs12238738 with p = 2.08 × 10(-5)) while the fourth locus was GPC6 at 13q32 (the top SNP was rs17196161 with p = 3.12 × 10(-5)).
Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck.
Panda et al., Calcutta, India. In Ann Surg Oncol, 2012
The aim of this study was to understand the association of candidate tumor suppressor genes PHF2, FANCC, PTCH1, and XPA located in this region in the development of HNSCC.
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.
Kato et al., Tokyo, Japan. In Nat Cell Biol, 2011
Here, we characterized a protein kinase A (PKA)-dependent histone lysine demethylase complex, PHF2-ARID5B.
Structural basis for human PHF2 Jumonji domain interaction with metal ions.
Cheng et al., Atlanta, United States. In J Mol Biol, 2011
the crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined.
Plant homeodomain fingers form a helping hand for transcription.
Shiekhattar et al., Barcelona, Spain. In Epigenetics, 2011
Several recent publications demonstrate a co-activator function for a subgroup of plant homeodomain fingers, which in humans comprises PHF2, PHF8 and KIAA1718.
Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma.
Panda et al., Calcutta, India. In Mol Cancer, 2007
Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis.
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