Association of chromosome 19 to lung cancer genotypes and phenotypes.
Shanghai, China. In Cancer Metastasis Rev, Jun 2015
Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2.
The role of hypoxia and Morg1 in renal injury.
Jena, Germany. In Eur J Clin Invest, Mar 2015
Under normoxic conditions constitutively expressed HIF-α subunits are hydroxylated by prolyl hydroxylases (PHD1, PHD2, and PHD3) and subsequently degraded by proteasomes.
Molecular oxygen sensing: implications for visceral surgery.
Heidelberg, Germany. In Langenbecks Arch Surg, 2012
Here, we outline specific functions of PHD enzymes in surgically relevant pathological conditions, and discuss how these functions might be exploited in order to support the treatment of surgically relevant diseases.