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Phosphatase and actin regulator 3

PHACTR3, Scapinin, scaffold-associated PP1 inhibiting protein, phosphatase and actin regulator 3
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, PP1, HAD, Prdm14, CAN
Papers on PHACTR3
Concurrent or sequential letrozole with adjuvant breast radiotherapy: Final results of the CO-HO-RT phase II randomized trial.
Azria et al., Montpellier, France. In Ann Oncol, Jan 2016
both located within the PHACTR3 gene on chromosome 20q13.33.
DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach.
Thunnissen et al., Amsterdam, Netherlands. In Br J Cancer, Apr 2015
METHODS: DNA hypermethylation of RASSF1A, APC, cytoglobin, 3OST2, PRDM14, FAM19A4 and PHACTR3 was analysed in sputum samples from symptomatic lung cancer patients and controls (learning set: 73 cases, 86 controls; validation set: 159 cases, 154 controls) by quantitative methylation-specific PCR.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers.
Haaf et al., Germany. In Cytogenet Genome Res, 2014
Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes.
Steenbergen et al., Amsterdam, Netherlands. In Epigenetics, 2014
In this study, cells were monitored for hypermethylation of 14 host genes (APC, CADM1, CYGB, FAM19A4, hTERT, mir124-1, mir124-2, mir124-3, MAL, PHACTR3, PRDM14, RASSF1A, ROBO3, and SFRP2) at 4 different stages during immortalization.
Combined sputum hypermethylation and eNose analysis for lung cancer diagnosis.
Thunnissen et al., Amsterdam, Netherlands. In J Clin Pathol, 2014
DNA hypermethylation of biomarkers RASSF1A, cytoglobin, APC, FAM19A4, PHACTR3, 3OST2 and PRDM14 was considered, and breathprints from exhaled breath samples were created using an electronic nose (eNose).
FOXE1 and SYNE1 genes hypermethylation panel as promising biomarker in colitis-associated colorectal neoplasia.
Forbes et al., London, United Kingdom. In Inflamm Bowel Dis, 2014
METHODS: SYNE1, FOXE1, NDRG4, and PHACTR3 genes were screened using methylation-specific PCR that permit the methylation status of the genes to be determined directly on biopsies.
Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats.
Yu et al., Beijing, China. In Chin Med J (engl), 2013
Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.
Phactr3/scapinin, a member of protein phosphatase 1 and actin regulator (phactr) family, interacts with the plasma membrane via basic and hydrophobic residues in the N-terminus.
Sagara et al., Matsumoto, Japan. In Plos One, 2013
We have previously shown that phactr3, also known as scapinin, localizes to the plasma membrane, including lamellipodia and membrane ruffles.
Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.
Van Criekinge et al., Amsterdam, Netherlands. In J Pathol, 2013
For 12 genes (CLIC3, CREB3L1, FAM19A4, LFNG, LHX1, MRC2, NKX2-8, NPTX-1, PHACTR3, PRDM14, SOST and TNFSF13) specific methylation in HPV-containing cell lines was confirmed by semi-quantitative methylation-specific PCR.
Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array‑based comparative genomic hybridization.
Zhang et al., Beijing, China. In Oncol Rep, 2013
Integrated analysis indicated that overexpression of PDP1, TRIB1, C13orf27, FOXA2, PMEPA1 and PHACTR3 was associated with gains, and underexpression of FHOD, SMAD4 and BCL2 was associated with losses.
DNA methylation of phosphatase and actin regulator 3 detects colorectal cancer in stool and complements FIT.
Meijer et al., Amsterdam, Netherlands. In Cancer Prev Res (phila), 2012
DNA methylation of phosphatase and actin regulator 3 is associated with colorectal cancer.
Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm.
Cole et al., Sydney, Australia. In J Biol Chem, 2011
Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain.
Identification of genes associated with non-small-cell lung cancer promotion and progression.
Tanic et al., Belgrade, Serbia. In Lung Cancer, 2010
E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses
Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton.
Taniguchi et al., Matsumoto, Japan. In Plos One, 2008
scapinin enhances cell spreading and motility through direct interaction with actin and PP1 plays a regulatory role in scapinin-induced morphological changes
Investigation of QTL regions on Chromosome 17 for genes associated with meat color in the pig.
Rothschild et al., Ames, United States. In J Anim Breed Genet, 2008
The total length of the new SSC17 linkage map was 126.6 cM and additional markers including endothelin 3 (EDN3) and phosphatase and actin regulator 3 (PHACTR3) genes were assigned at positions 119.4 cM and 122.9 cM, respectively.
Paramutation-like effects at the mouse scapinin (Phactr3) locus.
Schlote et al., Halle, Germany. In J Mol Biol, 2008
Phactr3 exon 1C splice variant is potentially strain specific regulated, leading to the expression of only one allele of the reciprocal crosses.
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