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Pleckstrin homology domain containing, family O member 2

PH domain-containing protein
Top mentioned proteins: Actin, PTEN, CAN, PI3K, Akt
Papers on PH domain-containing protein
In vitro interaction between coxsackievirus B3 VP1 protein and human pleckstrin homology domain retinal protein (PHR1).
Huang et al., Nanchang, China. In Virus Genes, Oct 2015
The results revealed that the human Pleckstrin Homology Domain Retinal protein (PHR1), a PH domain-containing protein with low expression in the heart and high expression in the brain, interacts with CVB3 VP1, a major structural protein of CVB3.
CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
Zhang et al., Beijing, China. In J Mol Cell Biol, 2014
Previous studies demonstrated that the PH domain-containing protein CKIP-1 plays an important role in the development of osteoblasts and cardiomyocytes.
A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton.
Zhong et al., Guangzhou, China. In Biocell, 2012
Here we showed that a novel PH domain-containing protein, PEPP2, displayed moderate phosphoinositide binding specificity.
The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration.
Marshall et al., Winnipeg, Canada. In Plos One, 2012
The intracellular signaling processes controlling malignant B cell migration and tissue localization remain largely undefined.
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis.
Emr et al., Ithaca, United States. In Embo J, 2012
Furthermore, we identify a tandem PH domain-containing protein, Opy1, as a novel Mss4-interacting protein that partially colocalizes with PIK patches.
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP).
Okamura et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2012
Monitoring of PI(3,4)P(2) levels with the pleckstrin homology (PH) domain from tandem PH domain-containing protein (TAPP1) fused with GFP (PH(TAPP1)-GFP) by confocal microscopy in amphibian oocytes showed an increase of fluorescence intensity during depolarization to 0 mV, consistent with 5' phosphatase activity of VSP toward PI(3,4,5)P(3).
Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site.
Gavin et al., Heidelberg, Germany. In Plos One, 2011
The PH domain-containing protein Slm1 from budding yeast Saccharomyces cerevisiae is required for actin cytoskeleton polarization and cell growth.
Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum.
Iijima et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2010
Two of these, the serine/threonine kinase Akt/protein kinase B and the PH domain-containing protein PhdA, were previously characterized as PtdInsP(3)-binding proteins.
Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants.
Fukuda et al., Tokyo, Japan. In Development, 2009
Here, we report on newly identified VAN3 regulators: the CVP2 (cotyledon vascular pattern 2) 5 PTase, which is considered to degrade IP(3) and also to produce PtdIns(4)P from PtdIns(4,5)P(2); and a PH domain-containing protein, VAB (VAN3 binding protein).
Stochastic signal inputs for chemotactic response in Dictyostelium cells revealed by single molecule imaging techniques.
Ueda et al., Suita, Japan. In Biosystems, 2007
Downstream signaling molecules, such as PTEN and a PH domain-containing protein that are constituent parts of chemotactic signaling system, can also be followed at single molecule level in living cells, illuminating the stochastic nature of chemotactic signaling processes.
Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein.
Ueda et al., Suita, Japan. In J Cell Sci, 2006
To investigate the mechanisms, we visualized single molecules of green fluorescent protein tagged to Crac (Crac-GFP), a PH-domain-containing protein in D. discoideum cells.
PHR1, a PH domain-containing protein expressed in primary sensory neurons.
Valle et al., Baltimore, United States. In Mol Cell Biol, 2004
Previously, we identified PHR1 as an abundantly expressed gene in photoreceptors and showed that it encodes four isoforms, each with N-terminal pleckstrin homology (PH) and C-terminal transmembrane domains.
Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
Watanabe et al., Tokyo, Japan. In Biochimie, 2004
We isolated Veph, a novel gene encoding a pleckstrin homology (PH) domain-containing protein from a mouse.
Two distinct waves of membrane-proximal B cell antigen receptor signaling differentially regulated by Src homology 2-containing inositol polyphosphate 5-phosphatase.
Marshall et al., Winnipeg, Canada. In J Immunol, 2004
We have found that the PH domains of Bam32 and tandem PH domain-containing protein 2 (TAPP2) specify a temporally distinct wave of membrane recruitment compared with that of Bruton's tyrosine kinase (Btk), with recruitment of these two adaptors representing a later stage of the response.
G protein signaling events are activated at the leading edge of chemotactic cells.
Devreotes et al., Baltimore, United States. In Cell, 1998
The translocation of the PH domain-containing protein CRAC in D. discoideum to binding sites on the inner face of the plasma membrane reflects activation of the G protein-linked signaling system.
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