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Solute carrier organic anion transporter family, member 2A1

PGT, prostaglandin transporter PGT
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, OUT
Papers using PGT antibodies
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Najbauer Joseph, In PLoS ONE, 2002
... in the pGT-N38 vector (New England Biolabs).
Papers on PGT
The activating role of phospho-(Tyr)-calmodulin on the epidermal growth factor receptor.
Villalobo et al., Madrid, Spain. In Biochem J, Jan 2016
We show that phosphorylation of CaM by rat liver solubilized EGFR leads to a dramatic increase in the subsequent phosphorylation of poly-L-(Glu:Tyr) (PGT) by the receptor in the presence of ligand, both in the absence and in the presence of Ca(2+).
Development of a diagnostic co-dominant marker for stem rust resistance gene Sr47 introgressed from Aegilops speltoides into durum wheat.
Xu et al., Fargo, United States. In Theor Appl Genet, Dec 2015
tritici, Pgt) resistance gene Sr47, originally transferred from Aegilops speltoides to durum wheat (Triticum turgidum subsp.
Lysophosphatidic acid modulates prostaglandin signalling in bovine steroidogenic luteal cells.
Woclawek-Potocka et al., Olsztyn, Poland. In Prostaglandins Other Lipid Mediat, Sep 2015
The aim of the present study was to determine the influence of LPA on PGE2 and PGF2α synthesis and on the expression of enzymes involved in PG biosynthesis (PTGS2, mPGES-1, cPGES, mPGES-2, PGFS and 9-KPR), prostaglandin transporter (PGT), and prostaglandin receptors (EP1, EP2, EP3, EP4 and FP) in bovine steroidogenic luteal cells.
Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma.
Arakawa et al., Ōsaka, Japan. In J Gastroenterol Hepatol, Sep 2015
The total amount of biologically active PGE2 in tissues is determined by a balance of PG biosynthesis and degradation pathways, which involve the PG transporter (PGT).
ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.
Liu et al., Spokane, United States. In Cell, Aug 2015
Interaction of ATF5 with polyglutamylated tubulin (PGT) on the mother centriole and with PCNT in the PCM renders ATF5 as a required molecule in mother centriole-directed PCM accumulation and in PCM-dependent centriole formation.
Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.
Fulton et al., Baltimore, United States. In Prostaglandins Other Lipid Mediat, 2015
Multiple Drug Resistance-Associated Protein 4 (MRP4) and Prostaglandin Transporter (PGT) modulate PGE2 signaling by increasing or decreasing the levels of PGE2 available to cells.
The Prostaglandin Transporter: Eicosanoid Reuptake, Control of Signaling, and Development of High-Affinity Inhibitors as Drug Candidates.
Lu et al., United States. In Trans Am Clin Climatol Assoc, 2014
We discovered the prostaglandin transporter (PGT) and cloned the human cDNA and gene.
Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping.
Mastrangelo et al., Foggia, Italy. In Front Plant Sci, 2014
(Pgt), is one of the most destructive diseases of wheat.
Association mapping of North American spring wheat breeding germplasm reveals loci conferring resistance to Ug99 and other African stem rust races.
Pumphrey et al., West Lafayette, United States. In Bmc Plant Biol, 2014
tritici (Pgt) race TTKSK (Ug99) poses a severe threat to global wheat production because of its broad virulence on several widely deployed resistance genes.
Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group.
Dubcovsky et al., Manhattan, United States. In Science, 2013
tritici (Pgt), is a devastating disease that can cause severe yield losses.
Role of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.
Paul et al., Lyon, France. In J Virol, 2012
These studies have permitted the discovery of NAb families with great potential for both neutralization and neutralization breadth, such as PG, PGT, CH, and highly active agonistic anti-CD4 binding site antibodies (HAADs), of which VRC01 and its variants are members.
Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs.
Burmester et al., Marshfield, United States. In Ophthalmic Genet, 2012
we found no indication for an association between SNPs in the prostaglandin F(2alpha) receptor gene or SLCO2A1 and IOP response to prostaglandin analogs in a population of European descent.
Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing.
Horn et al., Berlin, Germany. In Hum Mutat, 2012
Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing.
Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.
Liu et al., Shanghai, China. In Am J Hum Genet, 2012
The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy.
The changing face of HIV vaccine research.
Nabel et al., Bethesda, United States. In J Int Aids Soc, 2011
Further, the identification of broadly neutralizing monoclonal antibodies (such as VRC01, a human monoclonal antibody capable of neutralizing over 90% of natural HIV-1 isolates, as well as PG and PGT antibodies that recognize conserved glycopeptide epitopes) has revealed new opportunities for vaccine design.
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Wilson et al., Los Angeles, United States. In Science, 2011
However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat.
Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes.
Charpigny et al., Paris, France. In Biol Reprod, 2010
expression in fetal membranesfound primarily in the choriodecidua
The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases.
Fedorenko et al., L'viv, Ukraine. In Biol Chem, 2010
Here, we highlight the importance of research on the genetic mechanisms that regulate moenomycin biosynthesis and that confer moenomycin resistance to bacteria in the development of novel anti-infectives based on PGT inhibition.
The prostaglandin transporter PGT transports PGH(2).
Schuster et al., United States. In Biochem Biophys Res Commun, 2010
that PGT may play a role in transporting PGH(2) across cellular membranes.
Identification and characterization of a prostaglandin transporter.
Schuster et al., United States. In Science, 1995
The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.
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