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PGC, pepsinogen C
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] (from NCBI)
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Top mentioned proteins: V1a, ACID, CAN, AMPK, Insulin
Papers using PGC antibodies
PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes
Koch Karl-Wilhelm, In PLoS ONE, 2009
... Anti-parvalbumin and anti-calcineurin A antibodies were from Swant, Bellinzona, Switzerland, anti-SIRT1, anti–PGC-1α and ferutinin were from Santa Cruz Biotechnology Inc., Santa Cruz, CA, ...
Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways.
Stadler Krisztian, In PLoS ONE, 2009
... Anti-Phospho-AMPKα (Thr172) and Anti-PGC-1α antibodies were from Cell signaling Technology, Inc (USA) ...
A comparative study of Florida strains of Cylindrospermopsis and Aphanizomenon for cylindrospermopsin production
Scott P.M. et al., In Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 2007
... were C18 (500 mg/3 ml, Supelco LC-18; Oakville, ON, Canada) and polygraphitized carbon (PGC) (HyperSep PGC, 100 mg/1 ml; Thermo Scientific, Waltham, MA, USA).
Mitochondrial disorders
Zeviani Massimo et al., In Cell Metabolism, 2003
... Anti-PGC-1α antibody was from Abcam; anti-AMPK and anti-AMPK-P antibodies ...
Golgi complex, endoplasmic reticulum exit sites, and microtubules in skeletal muscle fibers are organized by patterned activity.
Bozza Patricia T., In PLoS ONE, 2000
... Generation and genotyping of transgenic GAA-/- mice expressing PGC-1α in skeletal muscle (tgKO)Transgenic MCK- PGC-1α mice, generously ...
Papers on PGC
Fenofibrate inhibits atrial metabolic remodeling in atrial fibrillation through PPAR-α/Sirt1/PGC-1α pathway.
Li et al., Harbin, China. In Br J Pharmacol, Feb 2016
The peroxisome proliferator-activated receptor α (PPAR-α)/Sirtuin1 (Sirt1)/ PPAR co-activator α (PGC-1α) pathway plays an important role in maintaining energy metabolism.
5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.
Schnellmann et al., United States. In J Pharmacol Exp Ther, Feb 2016
Unexpectedly, both CP-809,101 and SB-242,084 increased RPTC respiration and PGC-1α mRNA expression in RPTC at 1-10 nM.
A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C.
Peng et al., Beijing, China. In Toxicol Sci, Feb 2016
Our in vitro study revealed a well-defined POD concentration of DOX below which adaptive induction of PGC-1α-mediated mitochondrial genes, including NRF-1, MnSOD, UCP2, and COX1, concurred with negligible changes in mitochondrial superoxide and cytotoxicity.
Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
Funaba et al., Kyoto, Japan. In Cell Biochem Funct, Feb 2016
UNASSIGNED: The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator-activated receptor (Ppar) γ coactivator-1α (Pgc-1α) and uncoupling protein 1 (Ucp1).
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
We investigated this in an in vitro model, in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bFGF) and activin A develop as epiblast-like cells (EpiLCs) and gain competence for a PGC-like fate.
Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.
Rada-Iglesias et al., Köln, Germany. In Cell Stem Cell, Feb 2016
Following implantation, mouse epiblast cells transit from a naive to a primed state in which they are competent for both somatic and primordial germ cell (PGC) specification.
Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.
Walsh et al., New York City, United States. In Cell Rep, Feb 2016
UNASSIGNED: The Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a transcriptional co-activator that plays a central role in adapted metabolic responses.
The regulation of autophagy during exercise in skeletal muscle.
Hood et al., York, United Kingdom. In J Appl Physiol, Jan 2016
A longer-term transcriptional program involving FoxO, TFEB, p53 and PGC-1α transcriptional regulators is also induced to fuel sustained increases in autophagic capacity.
Mechanism and Reconstitution In Vitro of Germ Cell Development in Mammals.
Saitou et al., Kyoto, Japan. In Cold Spring Harb Symp Quant Biol, Jan 2016
This in vitro mouse PGC specification/development system has led to the elucidation of signaling, transcriptional, and epigenetic regulation during germ cell development in a detailed fashion.
Caloric restriction and exercise "mimetics'': Ready for prime time?
Handschin, Basel, Switzerland. In Pharmacol Res, Jan 2016
Interestingly, many of these compounds activate related signaling pathways, most often postulated to act on the common downstream effector peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle.
Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function.
Suki et al., Boston, United States. In Nat Mater, Oct 2015
Variable stretch enhances ATP production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1α.
Beneficial action of resveratrol: How and why?
Eynard et al., Córdoba, Argentina. In Nutrition, Oct 2015
This increases the cytosolic cAMP that activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway, which in turn facilitates increased oxidation of fatty acids, mitochondrial biogenesis, mitochondrial respiration, and gluconeogenesis.
[Relationship between hepatitis C virus and the transcription coactivator PGC-1α--A review].
Peng et al., In Wei Sheng Wu Xue Bao, Sep 2015
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1α) is a transcription factor coactivator that plays an essential role in cellular energy metabolism, and cumulative studies link the abnormal high expression of PGC-1α to IR and T2DM.
Specifying and protecting germ cell fate.
Updike et al., Santa Cruz, United States. In Nat Rev Mol Cell Biol, Jul 2015
Recent studies have expanded our understanding of the factors and mechanisms that specify germ cell fate, including the partitioning of maternally supplied 'germ plasm', inheritance of epigenetic memory and expression of transcription factors crucial for primordial germ cell (PGC) development.
ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency.
Evans et al., Los Angeles, United States. In Cell Stem Cell, Jun 2015
Although glycolysis increases throughout the reprogramming process, we show that the estrogen-related nuclear receptors (ERRα and ERRγ) and their partnered co-factors PGC-1α and PGC-1β are transiently induced at an early stage, resulting in a burst of oxidative phosphorylation (OXPHOS) activity.
Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs.
Yuan et al., Shenyang, China. In J Gastroenterol Hepatol, 2011
Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies.
Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.
Ye et al., Stockholm, Sweden. In Plos One, 2010
Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.
The validity of a biomarker method for indirect detection of gastric mucosal atrophy versus standard histopathology.
Lin et al., Rīga, Latvia. In Dig Dis Sci, 2009
Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the stomach corpus.
[Correlation of pepsinogen C (PGC) gene insertion/deletion polymorphism to PGC protein expression in gastric mucosa and serum].
Yuan et al., Shenyang, China. In Ai Zheng, 2009
PGC gene insertion/deletion polymorphism is negatively related to PGC protein expression in gastric mucosa, but is not related to the serum PGC level.
[Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer].
Yuan et al., Shenyang, China. In Zhonghua Zhong Liu Za Zhi, 2008
Pepsinogen C insertion/deletion polymorphism and Helicobacter pylori infection seem to present a positive interaction in the development of gastric cancer.
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