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PiggyBac transposable element derived 1

PGBD1, piggyBac transposable element derived 1
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene product is specifically expressed in the brain, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Galp, apolipoprotein E, TNK1, Gab2, Clusterin
Papers on PGBD1
Replication of association between schizophrenia and chromosome 6p21-6p22.1 polymorphisms in Chinese Han population.
Lu et al., Beijing, China. In Plos One, 2012
In our previous two-stage genome-wide association study (GWAS), polymorphisms of zinc finger with KRAB and SCAN domains 4 (ZKSCAN4), nuclear factor-κB-activating protein-like (NKAPL), and piggyBac transposable element derived 1 (PGBD1), localized to chromosome 6p21-p22.1,
No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia.
Arai et al., Tokyo, Japan. In Am J Med Genet B Neuropsychiatr Genet, 2012
The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia.
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
Lerer et al., Jerusalem, Israel. In Int J Neuropsychopharmacol, 2012
In addition, gene-wide significant associations were found within three schizophrenia candidate genes: PGBD1, RELN and PRODH, replicating previously reported associations.
No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease.
Arai et al., Tokyo, Japan. In Dement Geriatr Cogn Dis Extra, 2012
BACKGROUND/AIMS: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer's disease (AD), and recent genome-wide association studies and meta-analyses have indicated that a single nucleotide polymorphism (SNP), rs3800324, in PGBD1 could be associated with AD and the age of onset.
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
Zhang et al., Beijing, China. In Nat Genet, 2011
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Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.
Younkin et al., Jacksonville, United States. In Hum Genet, 2011
PGBD1 and GALP) and for an additional nine previously suggested candidate genes.
Genome-wide association studies in Alzheimer's disease.
Tanzi et al., Berlin, Germany. In Hum Mol Genet, 2009
On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1).
Assessment of Alzheimer's disease case-control associations using family-based methods.
Bertram et al., United States. In Neurogenetics, 2009
In this study, we tested 27 genes (ACE, BDNF, CH25H, CHRNB2, CST3, CTSD, DAPK1, GALP, hCG2039140, IL1B, LMNA, LOC439999, LOC651924, MAPT, MTHFR, MYH13, PCK1, PGBD1, PRNP, PSEN1, SORCS1, SORL1, TF, TFAM, TNK1, GWA_14q32.13,
A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis.
Porto et al., Porto, Portugal. In Bmc Med Genet, 2007
RESULTS: A highly conserved ancestral haplotype defined by the SNP markers PGBD1-A, ZNF193-A, ZNF165-T (designated as A-A-T) was found associated with both abnormally low CD8+ T-lymphocyte numbers and the development of a severe clinical expression of HH.
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