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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphoribosylformylglycinamidine synthase

PFAS, FGARAT, phosphoribosylformylglycinamidine synthase, FGAM synthase
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Amidophosphoribosyltransferase, iMpact, V1a
Papers on PFAS
Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood.
Granum et al., Netherlands. In J Immunotoxicol, Mar 2016
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of synthetic compounds that have widespread use in consumer and industrial applications.
A New Fluorinated Surfactant Contaminant in Biota: Perfluorobutane Sulfonamide in Several Fish Species.
Backus et al., Ottawa, Canada. In Environ Sci Technol, Feb 2016
In this study, the PFAS alternative, perfluoro-1-butane-sulfonamide (FBSA), was identified for the first time in biota in homogenate samples of fish by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-ToF-MS) and quantified by ultra high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS).
Temporal trends of perfluoroalkyl substances in limed biosolids from a large municipal water resource recovery facility.
Torrents et al., College Park, United States. In J Environ Manage, Feb 2016
Overall, this study found that concentrations of the 7 detectable PFAS compounds remained unchanged over the 8-year period, a result that is consistent with other temporal studies of these compounds in sewage sludges.
Evaluating the impact of a fluoropolymer plant on a river macrobenthic community by a combined chemical, ecological and genetic approach.
Polesello et al., Brugherio, Italy. In Sci Total Environ, Jan 2016
The macrobenthic community living downstream of the industrial discharge was chronically exposed to a mixture of perfluoroalkyl substances (PFAS), with perfluorooctanoic acid as the main compound, at concentrations up to several μgL(-1).
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.
Valladares-Salgado et al., Houston, United States. In Sci Rep, Dec 2015
A meta-analysis of the European GLGC and our Hispanic datasets identified five novel regions reaching genome-wide significance: two for total cholesterol (FN1 and SAMM50), two for HDL cholesterol (LOC100996634 and COPB1) and one for LDL cholesterol (LINC00324/CTC1/PFAS).
Exploring the Use of Molecular Docking to Identify Bioaccumulative Perfluorinated Alkyl Acids (PFAAs).
Hungerbuehler et al., Zürich, Switzerland. In Environ Sci Technol, Nov 2015
Methods to predict the bioaccumulation potential of per- and polyfluorinated alkyl substances (PFAS) are sorely needed, given the proliferation of these substances and lack of data on their properties and behavior.
Disruption of host antiviral resistances by gammaherpesvirus tegument proteins with homology to the FGARAT purine biosynthesis enzyme.
Lieberman et al., Philadelphia, United States. In Curr Opin Virol, Oct 2015
All known gammaherpesviruses encode at least one conserved tegument protein that contains sequence homology to the cellular purine biosynthesis enzyme: phosphoribosylformylglycineamide amidotransferase (FGARAT, or PFAS).
Perfluoroalkyl and polyfluoroalkyl substances in consumer products.
Fiedler et al., Schmallenberg, Germany. In Environ Sci Pollut Res Int, Oct 2015
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are used in a wide range of products of all day life.
Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults.
Su et al., Taipei, Taiwan. In Int J Hyg Environ Health, Jul 2015
BACKGROUND: Few studies have explored the association between perfluoroalkyl substances (PFAS) and reproductive hormones in adolescents and young adults.
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production.
Feng et al., Los Angeles, United States. In Mol Cell, May 2015
We show that viral homologs of phosphoribosylformylglycinamidine synthetase (PFAS), although lacking intrinsic enzyme activity, recruit cellular PFAS to deamidate and activate RIG-I.
Brain region-specific perfluoroalkylated sulfonate (PFSA) and carboxylic acid (PFCA) accumulation and neurochemical biomarker responses in east Greenland polar bears (Ursus maritimus).
Styrishave et al., Copenhagen, Denmark. In Environ Res, Apr 2015
Results from the present study support the hypothesis that PFAS concentrations in polar bears from East Greenland have exceeded the threshold limits for neurochemical alterations.
Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach.
Sandanger et al., Tromsø, Norway. In Environ Int, Apr 2015
The present study investigated associations between THs, thyroid binding proteins (TH-BPs) and PFAS concentrations in pregnant women from Northern Norway.
Japanese cedar pollen-based subcutaneous immunotherapy decreases tomato fruit-specific basophil activation.
Urisu et al., Japan. In Int Arch Allergy Immunol, 2014
BACKGROUND: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit.
Neural correlates of cerebellar-mediated timing during finger tapping in children with fetal alcohol spectrum disorders.
Meintjes et al., Cape Town, South Africa. In Neuroimage (amst), 2014
The alcohol-exposed children showed smaller activation increases during rhythmic tapping in right crus I than the control children and the most severely affected children with either FAS or PFAS showed smaller increases in vermis IV-V.
Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in drinking water treatment: a review.
Anderson et al., Waterloo, Canada. In Water Res, 2014
This article reviews perfluoroalkyl and polyfluoroalkyl substance (PFAS) characteristics, their occurrence in surface water, and their fate in drinking water treatment processes.
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