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promotes survival of ventral midbrain dopaminergic neurons and motor neurons; may mediate increase in dopamine-dependent behavioral parameters [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GDNF, CAN, RET, Acetyl-CoA Carboxylase, GFRalpha1
Papers on Persephin
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo.
Åman et al., Göteborg, Sweden. In Oncotarget, Dec 2015
The receptor tyrosine kinase (RTK) encoding RET was previously identified as a putative downstream target gene to FUS-DDIT3 and here we show that cultured MLS cells expressed phosphorylated RET together with its ligand Persephin.
Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.
Uzawa et al., Chiba, Japan. In Mol Carcinog, Aug 2015
Persephin (PSPN) is a neurotrophic factor of the glial cell line-derived neurotrophic factor (GDNF) family that promotes survival of multiple populations of neurons.
The effect of lentivirus-mediated PSPN genetic engineering bone marrow mesenchymal stem cells on Parkinson's disease rat model.
Xie et al., Qingdao, China. In Plos One, 2013
Persephin (PSPN) is one of the neurotrophic factors of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which have been found to promote the survival of specific populations of neurons.
Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease.
Bespalov et al., Helsinki, Finland. In Mol Cell Neurosci, 2010
Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex.
Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.
Hingtgen et al., Indianapolis, United States. In Neuroscience, 2009
Persephin, another member of the GFL family thought to be important in development, was unable to induce an enhancement in the release of iCGRP.
Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.
Borrego et al., Spain. In J Pediatr Surg, 2008
No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients.
Transforming growth factor beta cooperates with persephin for dopaminergic phenotype induction.
Krieglstein et al., Göttingen, Germany. In Stem Cells, 2008
TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype
[Neurotrophic factors of the GDNF family and their receptors are detectable in spiral ganglion cells of normal hearing as well as of deafened rats].
Stöver et al., Hannover, Germany. In Laryngorhinootologie, 2006
METHODS: In the present study we examined the expression pattern of members of the GDNF family (GDNF, Neurturin, Artemin, Persephin) and their relating receptors (Ret, GFRalpha1 - 3) as well as BDNF and trkB on spiral ganglion cells of normal hearing and experimentally deafened rats (10 % neomycine).
The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons.
Widmer et al., Bern, Switzerland. In Brain Res Bull, 2006
PSPN acts potent neurotrophic factor that may play an important role in the structural development and plasticity of ventral mesencephalic dopaminergic neurons
The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: evidence for a complex network in acute inflammation.
Dipietro et al., Maywood, United States. In Cytokine, 2005
Utilizing a mouse cDNA array containing 514 chemokine and chemokine related genes, the loss of MCP-1 was observed to cause a significant upregulation of nine genes (Decorin, Persephin, IL-1beta, MIP-2, MSP, IL1ra, CCR5, CCR3, IL-11) and significant downregulation of two genes (CCR4 and CD3Z) in acute wounds.
Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata.
Del Fiacco et al., Monserrato, Italy. In Brain Res, 2005
The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons.
Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease.
Arenas et al., Stockholm, Sweden. In Mol Cell Neurosci, 2002
PSP promotes the survival and neurite outgrowth of midbrain dopamine neurons in vitro as potently and efficiently as GDNF.
Effects of cerebral ischemia in mice deficient in Persephin.
Hoffer et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2002
Mice lacking Pspn by homologous recombination show normal development and behavior, but are hypersensitive to cerebral ischemia.
Glial line-derived neurotrophic factor (GDNF): Biological activities.
W, In Folia Morphol (warsz), 1998
Recent findings revealed that GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ARTN) are members of the GDNF protein family and are structurally related to transforming growth factor protein family.
Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
Milbrandt et al., Saint Louis, United States. In Neuron, 1998
The glial cell line-derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a multicomponent receptor system composed of a high-affinity binding component (GFRalpha1-GFRalpha4) and a common signaling component (RET).
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