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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, FATE, HAD, ROD, Rom
Papers on Peripherin
Partial dedifferentiation of murine radial glia type neural stem cells by Brn2 and c-Myc yields early neuroepithelial progenitors.
Edenhofer et al., Bonn, Germany. In J Mol Biol, Dec 2015
The differentiation of cells converted by Brn-2/c-Myc yielded smooth muscle actin- and Peripherin-positive cells in addition to the neuronal marker TUJ1 and cells that are positive for the glial marker GFAP.
PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts.
Kim et al., Seoul, South Korea. In Stem Cell Reports, Jun 2015
Transplantation of PSA-NCAM(-) cells in a gradient manner mixed with PSA-NCAM(+) cells proportionally increased mesodermal tumor formation and unwanted grafts such as PERIPHERIN(+) cells or pigmented cells in the rat brain.
High prevalence of PRPH2 in autosomal dominant retinitis pigmentosa in france and characterization of biochemical and clinical features.
Hamel et al., Montpellier, France. In Am J Ophthalmol, Feb 2015
Peripherin-2 protein was produced in yeast and analyzed by Western blot.
Quantitative analysis of afferents expressing substance P, calcitonin gene-related peptide, isolectin B4, neurofilament 200, and Peripherin in the sensory root of the rat trigeminal ganglion.
Bae et al., Taegu, South Korea. In J Comp Neurol, 2015
Substance P (SP), calcitonin gene-related peptide (CGRP), and isolectin B4 (IB4) are widely used as markers for peripheral neurons with unmyelinated fibers, whereas neurofilament 200 (NF200), and Peripherin are used as markers for neurons with myelinated fibers, and with unmyelinated or small-caliber fibers, respectively.
The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.
Li et al., Farmington, United States. In Sci Rep, 2014
The overexpression of Neurogenin 1 (Neurog1) promoted the neurons to express genes related to sensory neurons (Peripherin, TrkA) and to further mature into TRPV1(+) nociceptive neurons.
Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.
Cayouette et al., Montréal, Canada. In J Neurosci, 2014
Interestingly, we report that loss of Numb in photoreceptors does not affect the localization of outer segment disk membrane proteins, such as rhodopsin, Peripherin-rds, Rom-1, and Abca4, but significantly disrupts the localization of the rod cyclic nucleotide-gated (Cng) channels, which accumulates on the inner segment plasma membrane in addition to its normal localization to the outer segments.
Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system.
Hu et al., Philadelphia, United States. In Neurogastroenterol Motil, 2014
A small population of NIBP-expressing cells and fibers in extra-ganglionic and intra-ganglionic area were negative for pan-neuronal markers HuD or Peripherin.
Regenerative process evaluation of neuronal subclasses in chagasic patients with megacolon.
da Silveira et al., Uberlândia, Brazil. In Hum Immunol, 2013
A neuronal regeneration marker (GAP-43) was used in combination with a pan-neuronal marker (Peripherin) and several neuropeptides markers (cChat, Substance P, NPY, VIP and NOS), and it was considered as positive just with the combination of these markers.
Neurosensory development and cell fate determination in the human cochlea.
Chuva de Sousa Lopes et al., Leiden, Netherlands. In Neural Dev, 2012
Ubiquitous Peripherin expression by spiral ganglion neurons gradually diminished and became restricted to the type II spiral ganglion neurons by 18 weeks.
Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.
Nixon et al., New York City, United States. In J Neurosci, 2012
rather than forming an independent structure, peripherin is a subunit of neurofilaments in the adult peripheral nervous system
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Inherited macular dystrophies and differential diagnostics.
Jašinskas et al., Kaunas, Lithuania. In Medicina (kaunas), 2011
It is known seven gene mutations (ABCA4, ELOVL4, PROML1, VMD2, Peripherin/RDS, TIMP3, XLRS), which may cause inherited macular dystrophies development.
Isoform-specific expression and ratio changes accompany oxidant-induced peripherin aggregation in a neuroblastoma cell line.
Robertson et al., Toronto, Canada. In Brain Res, 2011
Peripherin isoform expression and inclusion formation serve a physiologically relevant role in the pathology of amyotrophic lateral sclerosis.
Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos.
Malicki et al., Boston, United States. In Embo J, 2011
B9d2, Inversin, and Nephrocystin 5 support, in turn, the transport of a cargo protein, Opsin, but not another photoreceptor ciliary transmembrane protein, Peripherin.
Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis.
Okamoto et al., Maebashi, Japan. In J Neurol Sci, 2011
although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions
Expression of peripherin in human cochlea.
Rask-Andersen et al., Uppsala, Sweden. In Cell Tissue Res, 2010
study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP
PRPH2 (Peripherin/RDS) mutations associated with different macular dystrophies in a Spanish population: a new mutation.
García et al., Valladolid, Spain. In Eur J Ophthalmol, 2010
PURPOSE: To assess the occurrence of PRPH2 mutations in patients presenting macular dystrophies and to describe their phenotype-genotype correlation.
Clinicopathological case series of four patients with inherited macular disease.
Da Cruz et al., London, United Kingdom. In Invest Ophthalmol Vis Sci, 2009
Peripherin labeling of outer segments was nonuniform, and EM showed discs arranged in whorllike structures.
Transgenic mice expressing the Peripherin-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence.
Sarsero et al., Australia. In Transgenic Res, 2008
Transgenic mice expressing the PRPH-EGFP genomic reporter display intrinsic peripheral nervous system fluorescence.
Intramural ganglion structures in esophageal atresia: a morphologic and immunohistochemical study.
Tovar et al., Messina, Italy. In Int J Pediatr, 2008
The specimens were fixed in 5% buffered formalin, included in paraffin and cut in 5 micron sections that were stained with hematoxilin and eosin (H and E), and immunohistochemical stainings for Actin, S-100 protein, Neurofilament, Neuron-Specific-Enolase, Chromogranin A and Peripherin were evaluated under the microscope.
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