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Period homolog 3

period 3, Per3, mPer3
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: HAD, AGE, CLOCK, CAN, period 2
Papers on period 3
Fit for Birth - the effect of weight changes in obese pregnant women on maternal and neonatal outcomes: a pilot prospective cohort study.
Wilding et al., Liverpool, United Kingdom. In Clin Obes, Feb 2016
Only 385 women had weights measured in all three study assessment periods (6-20 weeks, 20 + 1 to 32 weeks and >32 weeks gestation) while 427 women had weights measured in period 3. Individual patterns of weight gain varied widely and missing data were common and non-random.
Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated.
Nolte et al., Québec, Canada. In J Allergy Clin Immunol Pract, Feb 2016
In period 3, subjects received once-daily grass and ragweed SLIT tablets within 5 minutes (simultaneous intake).
Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers.
Kayser et al., Rotterdam, Netherlands. In Forensic Sci Int Genet, Jan 2016
We found that although in general mRNA-based estimation of time categories was less accurate than hormone-based estimation, the use of three mRNA markers HSPA1B, MKNK2 and PER3 together with melatonin and cortisol generally enhanced the time prediction accuracy relative to the use of the two hormones alone.
Staphylococcus aureus Bacteremia in Children: Changes During Eighteen Years.
Figueras-Nadal et al., Barcelona, Spain. In Pediatr Infect Dis J, Dec 2015
Four study periods were established: period 1, 1995-1999; period 2, 2000-2002; period 3, 2006-2008 and period 4, 2010-2012.
[Circadian markers and genes in bipolar disorder].
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Summer-Long Grazing of High vs. Low Endophyte (Neotyphodium coenophialum)-Infected Tall Fescue by Growing Beef Steers Results in Distinct Temporal Blood Analyte Response Patterns, with Poor Correlation to Serum Prolactin Levels.
Matthews et al., Lexington, United States. In Front Vet Sci, 2014
We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, day 0-36; period 2, day 37-58; and period 3, day 59-85).
Systematic review of laparoscopic versus open surgery in the treatment of non-parasitic liver cysts.
Minni et al., Bologna, Italy. In Updates Surg, 2014
The data analysis was conducted by dividing the sample into three periods in relation to the development of laparoscopic surgery: period 1 (P1), 1990-1995 "pioneering" period of laparoscopy; period 2 (P2), 1996-2000 period of the "development of laparoscopy"; period 3 (P3), 2001-2011 period of "diffusion of laparoscopy."
Clock genes: their role in colorectal cancer.
Gazouli et al., Athens, Greece. In World J Gastroenterol, 2014
Increased expression of positive regulators of this circadian system such as BMAL1 has been related to decrease overall survival while decreased expression of negative regulators such as PER2 and PER3 is connected with poorer differentiation, increased aggressiveness and worse prognosis.
Circadian abnormalities as markers of susceptibility in bipolar disorders.
Etain et al., Créteil, France. In Front Biosci (schol Ed), 2013
Several circadian genes have been found to be associated with bipolar disorders: at least three studies have reported positive associations for each of CLOCK, NPAS2, ARNTL1, NR1D1, PER3, RORB and CSNK1epsilon.
Changing spectrum of biopsy-proven primary glomerular diseases over the past 15 years: a single-center study in China.
Chen et al., Shanghai, China. In Contrib Nephrol, 2012
The patients were grouped according to a 3-year interval, 1997-1999 (period 1), 2000-2002 (period 2), 2003-2005 (period 3), 2006-2008 (period 4), 2009-2011 (period 5), and divided into three age groups (<20, 20-59, and ≥60 years old).
There is no association between the circadian clock gene HPER3 and cognitive dysfunction after noncardiac surgery.
Gogenur et al., Denmark. In Anesth Analg, 2012
No significant association was found between the clock-gene PER3(5/5) genotype and postoperative cognitive dysfunction at 1 week after noncardiac surgery.
Hafnium isotope evidence for a transition in the dynamics of continental growth 3.2 Gyr ago.
Whitehouse et al., Copenhagen, Denmark. In Nature, 2012
These data suggest a transitional period 3.5-3.2
PER3 polymorphism and insomnia severity in alcohol dependence.
Burmeister et al., Ann Arbor, United States. In Sleep, 2012
PER3 genotype contributed unique variance in predicting insomnia severity in alcohol dependence patients
Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.
Dijk et al., Guildford, United Kingdom. In Chronobiol Int, 2012
Data suggest that the PER3 variable number tandem repeat specifically affects measures of sleep timing and may also modify the effects of sleep on health outcome measures.
Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.
Wolf et al., Dortmund, Germany. In Proc Natl Acad Sci U S A, 2012
Per3 exists as homodimers, which are mediated by interactions of the PAS-B beta-sheet surface including a highly conserved tryptophan Trp 359. PER3 homodimers are additionally stabilized by an N-terminal region including a predicted helix-loop-helix motif.
Tissue-specific function of Period3 in circadian rhythmicity.
Yamazaki et al., Nashville, United States. In Plos One, 2011
Per3 is a key player in the mammalian circadian system.
Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.
Balmain et al., San Francisco, United States. In J Clin Oncol, 2010
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.
Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer.
Tinetti et al., New Haven, United States. In Jama, 2007
Time was categorized as period 1 (no screening coverage, 1992-1997), period 2 (limited coverage, January 1998-June 2001), and period 3 (universal coverage, July 2001-December 2002).
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
Erlichman et al., Rochester, United States. In J Clin Oncol, 2002
In period 3, all patients received eniluracil/5-FU tablets BID for 28 days.
Crust formation and plate motion in the early archean.
Layer et al., In Science, 1992
Paleomagnetic data with good age control from at least one ancient craton suggest that plate motion was at normal minimum average velocities of about 17 millimeters per year with respect to the poles during the period 3.5 billion to 2.4 billion years ago.
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