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Period homolog 1

period 1, period I
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, iMpact, OUT
Papers on period 1
Relocation of patients after cardiac surgery: is it worth the effort?
Jakobsen et al., Århus, Denmark. In Acta Anaesthesiol Scand, Feb 2016
The study included 4,515 patients who underwent cardiac surgery at Aarhus University Hospital during the period 1 April 2006 to 31 December 2012.
Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated.
Nolte et al., Québec, Canada. In J Allergy Clin Immunol Pract, Feb 2016
In period 1, subjects received once-daily timothy grass SLIT tablet (2800 bioequivalent allergen unit; Merck, Inc, Kenilworth, NJ/ALK, Hørsholm, Denmark).
Staphylococcus aureus Bacteremia in Children: Changes During Eighteen Years.
Figueras-Nadal et al., Barcelona, Spain. In Pediatr Infect Dis J, Dec 2015
Four study periods were established: period 1, 1995-1999; period 2, 2000-2002; period 3, 2006-2008 and period 4, 2010-2012.
[A multicenter study of the antimicrobial susceptibility of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis from community acquired infections in Saitama, Japan].
Maesaki et al., In Jpn J Antibiot, Oct 2015
The fourth-year survey was conducted in three of the period 2007-2010 (period I, 2007-2008; period II, 2008-2009; period III, 2009-2010).
Change of fatty acid composition of the lumbar longissimus during the final stage of fattening in the Japanese Black cattle.
Oyama et al., Kōbe, Japan. In Anim Sci J, Sep 2015
The increasing rate of MUFA rose from 0.21 percentage points (pp)/month at period 1 (from the first sampling to the second sampling) to 0.84 pp/month at period 2 (from the second sampling to the slaughter).
Multiplicity of hypoxia-inducible transcription factors and their connection to the circadian clock in the zebrafish*.
Egg et al., Innsbruck, Austria. In Physiol Biochem Zool, Mar 2015
Previously, we demonstrated that Hif-1α directly binds to defined E-boxes of the period 1 gene, leading to a sustained dampening of its oscillation amplitude.
Summer-Long Grazing of High vs. Low Endophyte (Neotyphodium coenophialum)-Infected Tall Fescue by Growing Beef Steers Results in Distinct Temporal Blood Analyte Response Patterns, with Poor Correlation to Serum Prolactin Levels.
Matthews et al., Lexington, United States. In Front Vet Sci, 2014
We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, day 0-36; period 2, day 37-58; and period 3, day 59-85).
Systematic review of laparoscopic versus open surgery in the treatment of non-parasitic liver cysts.
Minni et al., Bologna, Italy. In Updates Surg, 2014
The data analysis was conducted by dividing the sample into three periods in relation to the development of laparoscopic surgery: period 1 (P1), 1990-1995 "pioneering" period of laparoscopy; period 2 (P2), 1996-2000 period of the "development of laparoscopy"; period 3 (P3), 2001-2011 period of "diffusion of laparoscopy."
Association between motor functioning and leisure participation of children with physical disability: an integrative review.
Hale et al., Dunedin, New Zealand. In Dev Med Child Neurol, 2014
METHOD: We conducted a systematic electronic search of key databases from the period 1 January 2001 to 30 April 2014 using relevant keywords.
Risk of a thrombotic event after the 6-week postpartum period.
Elkind et al., New York City, United States. In N Engl J Med, 2014
The risk of primary thrombotic events was markedly higher within 6 weeks after delivery than in the same period 1 year later, with 411 events versus 38 events, for an absolute risk difference of 22.1 events (95% confidence interval [CI], 19.6 to 24.6) per 100,000 deliveries and an odds ratio of 10.8 (95% CI, 7.8 to 15.1).
Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial.
Kavanaugh et al., Vienna, Austria. In Lancet, 2014
Patients with early (<1 year duration) rheumatoid arthritis naive to methotrexate were randomly allocated (by interactive voice response system, in a 1:1 ratio, block size four) to adalimumab (40 mg every other week) plus methotrexate (initiated at 7·5 mg/week, increased by 2·5 mg every 1-2 weeks to a maximum weekly dose of 20 mg by week 8) or placebo plus methotrexate for 26 weeks (period 1).
Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial.
Gibson et al., Newcastle, Australia. In Lancet, 2012
Gabapentin significantly improved cough-specific quality of life compared with placebo (between-group difference in LCQ score during treatment period 1·80, 95% CI 0·56-3·04; p=0·004; number needed to treat of 3·58).
Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
Consortium for Clinical Investigation of Neurologic Channelopathies et al., Rochester, United States. In Jama, 2012
Because of a statistically significant interaction between treatment and period for this outcome, primary end point is presented by period (period 1 means were 2.53 for mexiletine and 4.21 for placebo; difference, -1.68; 95% CI, -2.66 to -0.706; P < .001;
The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes.
Myers et al., Huntsville, United States. In Mol Cell Biol, 2012
dose-specific glucocorticoid responses are specific, able to distinctly express a single gene,PER1; mapped PER1 response to a single GR binding site; overexpression of PER1 led to regulation of additional circadian rhythm genes suggesting hypersensitive expression of PER1 impacts circadian gene expression
Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast.
Togari et al., Nagoya, Japan. In Chronobiol Int, 2012
treatment with isoprenaline or dexamethasone induces circadian expression of hPer1, hPer2, hPer3, and hBMAL1
PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells.
Kijima et al., Hirosaki, Japan. In Eur J Cancer, 2011
PER1 and PER3 may modulate apoptotic reactions to cisplatin in gingival cancer cells
Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer.
Imada et al., Yokohama, Japan. In Oncol Rep, 2011
Overexpression of the Bmal1 gene and reduced expression of the Per1 gene may thus be useful predictors of liver metastasis.
Rhythmic diurnal gene expression in human adipose tissue from individuals who are lean, overweight, and type 2 diabetic.
Johnston et al., United Kingdom. In Diabetes, 2011
Lean individuals exhibited significant (P < 0.05) temporal changes of core clock (PER1, PER2, PER3, CRY2, BMAL1, and DBP) and metabolic (REVERBalpha, RIP140, and PGC1alpha) genes.
Daily electrical silencing in the mammalian circadian clock.
Piggins et al., Manchester, United Kingdom. In Science, 2009
Some SCN neurons express a key clock gene, period 1 (per1).
Ottawa, Canada. In Unknown Journal, 0001
This is due to the red blood cells continuing to metabolize glucose post-withdrawal at a rate of 7% per hour.
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