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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Perforin 1

Perforin, PFP, PRF1
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD8, HAD, CD4, V1a
Papers using Perforin antibodies
A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation
Marx Alexander et al., In Diagnostic Pathology, 1996
... (T-cell receptor beta chains) (both Thermo Fisher Scientific, Waltham, MA, USA), CD5, CD8, CD10, CD56, Perforin (Leica, Wetzlar, Germany), and CD34 ...
Papers on Perforin
l-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors.
Spicer et al., Kuopio, Finland. In Int J Pharm, Mar 2016
Perforin is a cytolytic pore-forming glycoprotein secreted by cytotoxic effector cells.
Perforin Promotes Amyloid Beta Internalisation in Neurons.
Behbahani et al., Huddinge, Sweden. In Mol Neurobiol, Feb 2016
We here investigated how extracellular Aβ peptides are internalised and focused on three different pathways: (i) via endocytic mechanisms, (ii) via the receptor for advanced glycation end products (RAGE) and (iii) via the pore-forming protein perforin.
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
Tiede et al., Hannover, Germany. In Xenotransplantation, Feb 2016
Activation of plasma coagulation (thrombin-anti-thrombin complex; TAT) and complement (C3a, C5a) was studied in human platelet-free plasma (PFP) after co-incubation with PAEC.
Rapid screening of acetylcholinesterase inhibitors by Effect-Directed Analysis using LC × LC fractionation, a high throughput in vitro assay and parallel identification by Time of Flight mass spectrometry.
Lamoree et al., In Anal Chem, Feb 2016
The LC × LC fractionation method was validated using analytical standards and a C18 and pentafluorophenyl (PFP) stationary phase combination was selected for the two dimensional separation and fractionation in four 96 well plates.
Recurrent macrophage activation syndrome in spondyloarthritis and monoallelic missense mutations in PRF1: a description of one paediatric case.
Corona et al., Milano, Italy. In Clin Exp Rheumatol, Feb 2016
UNASSIGNED: ****************************************************************************.
Search for the potential "second-hit" mechanism underlying the onset of familial hemophagocytic lymphohistiocytosis type 2 by whole-exome sequencing analysis.
Zhou et al., Wuhan, China. In Transl Res, Jan 2016
UNASSIGNED: Familial hemophagocytic lymphohistiocytosis type 2 (FHL2), caused by perforin 1 (PRF1), is a genetic disorder of lymphocyte cytotoxicity that usually presents in the first 2 years of life and has a poor prognosis.
Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution.
Podack et al., Miami, United States. In J Leukoc Biol, Nov 2015
Pore-forming proteins containing the membrane attack complex Perforin domain were one of the first triumphs of an innate immune system needing to eliminate microbes and virally infected cells.
Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity.
Reisner et al., Israel. In Immunity, Nov 2015
Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs).
A Meta-analysis of the Significance of Granzyme B and Perforin in Noninvasive Diagnosis of Acute Rejection After Kidney Transplantation.
Su et al., Guangzhou, China. In Transplantation, Jul 2015
BACKGROUND: Previous studies have reported that granzyme B (GZMB) and perforin (PRF) could serve as noninvasive biomarkers in the diagnosis of acute rejection (AR) after kidney transplant.
Perforin and granzymes: function, dysfunction and human pathology.
Trapani et al., In Nat Rev Immunol, Jun 2015
A defining property of cytotoxic lymphocytes is their expression and regulated secretion of potent toxins, including the pore-forming protein perforin and serine protease granzymes.
Primary Immunodeficiencies Associated with EBV Disease.
Cohen, Bethesda, United States. In Curr Top Microbiol Immunol, 2014
Mutations in three genes associated with hemophagocytic lymphohistocytosis, PRF1, STXBP2, and UNC13D, can also predispose to severe chronic active EBV disease.
Perforin: an important player in immune response.
Demkow et al., Warsaw, Poland. In Cent Eur J Immunol, 2013
Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells.
Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.
Fairchild et al., Cleveland, United States. In J Immunol, 2012
Perforin/FasL-independent functions of hapten-primed CD8 T cells in a contact hypersensitivity model identify new functions for neutrophils in regulating effector CD8 T cell recruitment and immune responses in the skin.
NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.
Kemeny et al., Singapore, Singapore. In J Immunol, 2012
Perforin facilitates viral antigen uptake by pulmonary dendritic cells by inducing apoptosis in mice with influenza infection.
Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential.
Thimme et al., Freiburg, Germany. In J Hepatol, 2012
Perforin plays a dominant role in CD8+ T cell-mediated lysis of hepatitis C virus-replicating human hepatoma cells but that lysis may be limited in human chronic viral infection by the low perforin expression.
Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection.
Swain et al., Lincoln, United States. In J Virol, 2012
CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection.
CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy.
Lannes-Vieira et al., Rio de Janeiro, Brazil. In Plos Pathog, 2011
CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
Lieberman et al., Boston, United States. In Nat Immunol, 2011
How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain.
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Whisstock et al., Melbourne, Australia. In Nature, 2010
elucidation of the mechanism of perforin pore formation by determining the X-ray crystal structure of monomeric murine perforin, together with a cryo-electron microscopy reconstruction of the entire perforin pore
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Rao et al., Boston, United States. In Immunity, 2010
IL-2 stimulation induced the transcription factor eomesodermin (Eomes), upregulated perforin (Prf1) transcription, and repressed re-expression of memory CTL markers Bcl6 and IL-7Ralpha.
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