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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Rhox homeobox family, member 2

PEPP2, RhoxF2, THG-1, hPEPP2
member of homeobox PEPP subfamily, preferentially expressed in reproductive tissues; human homolog specifically expressed in testis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: OTEX, CAN, 18 U, PEPP3, POLYMERASE
Papers on PEPP2
Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies.
Hattori et al., Tokyo, Japan. In Plos One, Dec 2015
The homeobox protein, PEPP2 (RHOXF2), has been suggested as a cancer/testis (CT) antigen based on its expression pattern.
PAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia.
Kempski et al., London, United Kingdom. In Br J Haematol, Jul 2015
Novel PAX5-RHOXF2, PAX5-ELK3 and PAX5-CBFA2T2 rearrangements, which lead to aberrant expression of PAX5, were also identified.
Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.
Modarressi et al., Tehrān, Iran. In Cell J, 2014
MATERIALS AND METHODS: In this applied-descriptive study, the expression of 4 CTAs, namely acrosin binding protein (ACRBP), outer dense fiber 4 (ODF4), Rhox homeobox family member 2 (RHOXF2) and spermatogenesis associated 19 (SPATA19) were ana- lyzed at the transcript level in two breast cancer lines (MCF-7 and MDA-MB-231), 40 invasive ductal carcinoma samples and their adjacent normal tissues as well as 10 fibroadenoma samples by means of quantitative real-time reverse transcription polymerase chain reaction (RT-PCR).
A genome scale overexpression screen to reveal drug activity in human cells.
Nislow et al., Toronto, Canada. In Genome Med, 2013
Finally, we focused on the transcription factor RHOXF2 whose overexpression conferred resistance to DNA damaging agents.
Lactobacillus acidophilus and Lactobacillus crispatus culture supernatants downregulate expression of cancer-testis genes in the MDA-MB-231 cell line.
Motevaseli et al., Tehrān, Iran. In Asian Pac J Cancer Prev, 2013
Changes in expression of 5 cancer-testis antigens (CTAs), namely AKAP4, ODF4, PIWIL2, RHOXF2 and TSGA10 ,were analyzed by quantitative real time RT-PCR.
RHOXF2 gene, a new candidate gene for spermatogenesis failure.
Vialard et al., Le Blanc-Mesnil, France. In Basic Clin Androl, 2013
Abstract available from the publisher.
Are so-called cancer-testis genes expressed only in testis?
Movafagh et al., Tehrān, Iran. In Asian Pac J Cancer Prev, 2013
Here we analyzed expression of two previously known CT antigens, RHOXF2 and PIWIL2, in AML patients versus normal donors and found no significant difference in the expression of these genes between the two groups.
The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.
Wilkinson et al., San Diego, United States. In Hum Reprod, 2013
We generated antisera against RHOX proteins and used them for western blotting, immunohistochemical and immunofluorescence analyses of RHOXF1 and RHOXF2/2B protein expression.
A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton.
Zhong et al., Guangzhou, China. In Biocell, 2012
Here we showed that a novel PH domain-containing protein, PEPP2, displayed moderate phosphoinositide binding specificity.
Kinetic analysis of 3'-5' nucleotide addition catalyzed by eukaryotic tRNA(His) guanylyltransferase.
Jackman et al., Columbus, United States. In Biochemistry, 2012
The high-resolution crystal structure of human Thg1 reveals remarkable structural similarity between canonical DNA/RNA polymerases and eukaryotic Thg1.
Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning.
Kitamura et al., Tokyo, Japan. In Int J Oncol, 2012
RHOXF2 is highly expressed in some leukemia cell lines and a variety of human cancers. Results indicate that RHOXF2 is involved in carcinogenesis.
Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function.
Su et al., Kunming, China. In Bmc Evol Biol, 2010
In striking contrast to non-human primates, humans appear to have homogenized their two RHOXF2 copies by the endogenous retrovirus -mediated non-allelic recombination mechanism.
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
Doublié et al., Burlington, United States. In Proc Natl Acad Sci U S A, 2010
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.
Stocker et al., Zürich, Switzerland. In J Biol, 2009
Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential.
Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms.
Guo et al., Pittsburgh, United States. In Mol Pharmacol, 2009
In this study, we demonstrated for the first time that an epigenetic drug could up-regulate homeobox genes in the reproductive homeobox genes on chromosome X (Rhox) family, including murine Rhox5, Rhox6, and Rhox9 and human RhoxF1 and RhoxF2 in breast, colon, and other types of cancer cells.
Genome-wide analysis of cancer/testis gene expression.
Hide et al., Boston, United States. In Proc Natl Acad Sci U S A, 2009
Applying this core classification in a genome-wide survey we identified >30 CT candidate genes; 3 of them, PEPP-2, OTOA, and AKAP4, were confirmed as testis-restricted or testis-selective using RT-PCR, with variable expression frequencies observed in a panel of cancer cell lines.
The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.
Wilkinson et al., Houston, United States. In J Biol Chem, 2008
The human RHOX protein PEPP2 (RHOXF2) also had this ability, indicating that Unc5c repression is a conserved RHOX-dependent response.
Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics.
Rao et al., Baltimore, United States. In Cell Biochem Biophys, 2004
No ortholog of (ES) cell-derived homeobox containing gene (Ehox) could be identified in human, and the closest paralogs PEPP gene subfamily 1 (PEPP1), PEPP2, and extraembryonic, spermatogenesis, homeobox 1 (Esx1) were not expressed by ES cells and shared little homology.
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