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Peptidase C

PEP3, Vps18, hVps18
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Sox11, HAD, ACID, CAN, Id1
Papers on PEP3
Mitochondria-Directed Fluorescent Probe for the Detection of Hydrogen Peroxide near Mitochondrial DNA.
Yi et al., Shanghai, China. In Anal Chem, Nov 2015
In this study, a mitochondria-targeted fluorescence probe, pep3-NP1, has been designed and synthesized.
Can PEP-3 Provide a Cognitive Profile in Children with ASD? A Comparison Between the Developmental Ages of PEP-3 and IQ of Leiter-R.
Margari et al., Bari, Italy. In J Appl Res Intellect Disabil, Nov 2015
The aim of the study was to evaluate the usefulness of the Psychoeducational Profile-third edition (PEP-3) to estimate the general cognitive development of children with ASD.
PEP3 overexpression shortens lag phase but does not alter growth rate in Saccharomyces cerevisiae exposed to acetic acid stress.
Bakalinsky et al., Corvallis, United States. In Appl Microbiol Biotechnol, Oct 2015
Here, we report that overexpression of PEP3 which encodes a component of the HOPS and CORVET complexes involved in vacuolar biogenesis, shortened lag phase in Saccharomyces cerevisiae exposed to acetic acid stress.
Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.
Luzio et al., Cambridge, United Kingdom. In Traffic, Jul 2015
The mammalian homotypic fusion and vacuole protein sorting (HOPS) complex is comprised of six subunits: VPS11, VPS16, VPS18, VPS39, VPS41 and the Sec1/Munc18 (SM) family member VPS33A.
Dendritic cells induce specific cytotoxic T lymphocytes against prostate cancer TRAMP-C2 cells loaded with freeze- thaw antigen and PEP-3 peptide.
Yi et al., Chongqing, China. In Asian Pac J Cancer Prev, 2014
In this study, we investigated immune responses of cytotoxic T lymphocytes (CTLs) against TRAMP-C2 prostate cancer cells after activation by dendritic cells (DCs) loaded with TRAMP-C2 freeze-thaw antigen and/or PEP-3 peptide in vitro.
Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.
Li et al., Beijing, China. In Autophagy, 2014
In addition, the VPS33A(D251E) mutation enhanced interactions with other HOPS subunits, namely VPS41, VPS39, VPS18, and VPS11, except for VPS16.
Engineering novel anticoagulant proteins by motif grafting.
Wang et al., Beijing, China. In Protein Pept Lett, 2013
One of the recombinant proteins, pep3, was found to inhibit FXa with strong activity (IC50 of 152 nM) in vitro.
Utility of the Psychoeducational Profile-3 for assessing cognitive and language skills of children with autism spectrum disorders.
D'Entremont et al., Fredericton, Canada. In J Autism Dev Disord, 2013
The Psychoeducational Profile-3's (PEP-3) ability to estimate cognitive and language skills of 136 children (20-75 months) with autism spectrum disorders (ASDs) across a range of functioning, and the association between the PEP-3 and ASD symptomatology was examined using retrospective data.
Identification of candidate genes involved in marble color pattern formation in genus Salmo.
Sušnik Bajec et al., Slovenia. In Comp Biochem Physiol Part D Genomics Proteomics, 2013
Microarray results were validated by qRT-PCR and revealed four differentially expressed informative genes (hdac1, vps18, dct and scg2a) involved in animal pigmentation.
hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.
Klumperman et al., Utrecht, Netherlands. In Nat Commun, 2012
Knockdown of hVps41 or VAMP7 resulted in the accumulation of lysosome-associated membrane protein carriers, whereas knockdown of hVps39 or hVps18 did not, indicating that the effect of hVps41 is independent of CORVET/HOPS.
The cellular factors Vps18 and Mon2 are required for efficient production of infectious HIV-1 particles.
Kawaoka et al., Tokyo, Japan. In J Virol, 2011
Depletion of hVps18 or hMon2 reduced the efficient production of infectious HIV-1 virions in human cells.
A non-covalent peptide-based strategy for ex vivo and in vivo oligonucleotide delivery.
Divita et al., Montpellier, France. In Methods Mol Biol, 2010
We recently described a non-covalent strategy based on short amphiphatic peptides (MPG8/PEP3) that have been successfully applied ex vivo and in vivo for the delivery of therapeutic siRNA and PNA molecules.
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.
Akazawa et al., Kodaira, Japan. In Biochem Biophys Res Commun, 2006
ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18
The zebrafish mutant vps18 as a model for vesicle-traffic related hypopigmentation diseases.
Navarro et al., Mexico. In Pigment Cell Res, 2006
A deficiency of Vps18 in zebrafish larvae results in hepatomegaly and skin hypopigmentation.
Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.
Akazawa et al., Tokyo, Japan. In J Biol Chem, 2006
hVPS18 may play an important role in regulation of SNK activity through its ubiquitin ligase
A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.
Hopkins et al., Cambridge, United States. In Development, 2005
Mutation of the class C vacuolar protein sorting gene vps18 results in hepatomegaly associated with large, vesicle-filled hepatocytes.
ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion.
Martin et al., Madison, United States. In Nature, 1995
PEP3 was recently identified as phosphatidylinositol transfer protein (PtdInsTP), and here we report that PEP1 consists of the type I phosphatidylinositol-4-phosphate 5-kinase (PtdInsP5K).
Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion.
Martin et al., Madison, United States. In Nature, 1994
Here we show that one of the mammalian priming factors (PEP3) is identical to phosphatidylinositol transfer protein (PITP).
Electrophoretic study of enzymes from cereal aphid populations : 4. Detection of hidden genetic variation within populations of the grain aphid Sitobion avenae (F.) (Hemiptera: Aphididae).
Fox et al., Harpenden, United Kingdom. In Theor Appl Genet, 1985
A study of variation in three peptidases (PEP-3 to -5) in a parthenogenetic S. avenae field population at Rothamsted using serial one-dimensional polyacrylamide gel electrophoresis (involving changes of gel concentration and electrophoretic run-time) increased the overall number of "allozymes" (mobility variants) detected from 10 under standard conditions (6% gels, 2 h run-time) to 22, as well as revealing putative heterozygous banding patterns under some test conditions.
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