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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Paternally expressed 3

Peg3, GADD34, MyD116, PW1
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CHOP, V1a, HAD, ACID
Papers using Peg3 antibodies
GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
Cao Xu et al., In The Journal of Cell Biology, 1998
... The interaction between Smad7 and GADD34 were further confirmed with a β-gal filter lift assay and quantified by a liquid β-gal assay according to the manufacturer's instructions (CLONTECH Laboratories, Inc.) ...
Papers on Peg3
Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates-proof of concept for HIV mucosal pre-exposure prophylaxis.
Sinko et al., United States. In Drug Deliv Transl Res, Feb 2016
In MT-2 T cells, APV-PEG3.4
Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells.
Lee et al., Seoul, South Korea. In Mol Cells, Feb 2016
Basal expression levels of Growth Arrest and DNA Damage 34 (GADD34), a regulator of eIF2α, were higher in MCF-7/ADR cells compared to MCF-7 cells.
Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.
Shah et al., Tromsø, Norway. In Embo J, Feb 2016
Here, we show that the reactive oxygen species-generating NADPH oxidase-4 (Nox4) is induced downstream of ATF4, binds to a PP1-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2α phosphorylation and ATF4 levels.
Sensitivity improvement of a sandwich-type ELISA immunosensor for the detection of different prostate-specific antigen isoforms in human serum using electrochemical impedance spectroscopy and an ordered and hierarchically organized interfacial supramolecular architecture.
Hernández-López et al., Mexico. In Anal Chim Acta, Feb 2016
To address and minimize the issue of non-specific protein adsorption, an organic matrix (amine-PEG3-biotin/avidin) was assembled on the previously functionalized electrode surface to build up an ordered and hierarchically organized interfacial supramolecular architecture: Au/16-MHA/EG3SH/amine-PEG3-biotin/avidin.
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.
Hamburg et al., Boston, United States. In J Am Heart Assoc, Dec 2015
In PBMCs, ATF6 and spliced X-box-binding protein 1 (XBP-1) gene expression increased by 2.0- and 2.5-fold, respectively (both P<0.05), whereas CHOP and GADD34 decreased by ≈67% and 74%, respectively (both P<0.01).
Decorin as a multivalent therapeutic agent against cancer.
Iozzo et al., Philadelphia, United States. In Adv Drug Deliv Rev, Nov 2015
Upon receptor binding, decorin initiates signaling pathways within endothelial cells downstream of VEGFR2 that ultimately culminate in a Peg3/Beclin 1/LC3-dependent autophagic program.
Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players.
Rovere-Querini et al., Milano, Italy. In Cell Mol Life Sci, Jun 2015
These cells comprise the fibro-adipogenic precursors, the PW1-expressing cells and some interstitial cells associated with vessels (pericytes, mesoangioblasts and myoendothelial cells).
Genetics of Opisthorchis viverrini-related cholangiocarcinoma.
Teh et al., Khon Kaen, Thailand. In Curr Opin Gastroenterol, May 2015
MLL3 (13%) and IDH1/2 (2.8%)], WNT signaling [RNF43 (9.3%) and PEG3 (5.6%)] and KRAS/G protein signaling [GNAS (9.3%) and ROBO2 (9.3%)].
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy.
Iozzo et al., Philadelphia, United States. In Connect Tissue Res, 2014
A novel and emerging role of endorepellin is its ability to evoke autophagy by activating Peg3 and various canonical autophagic markers.
Regulation and function of the peg3 imprinted domain.
Kim et al., Baton Rouge, United States. In Genomics Inform, 2014
A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain.
Role of Tet1 in erasure of genomic imprinting.
Zhang et al., Boston, United States. In Nature, 2014
We show that despite their identical genotype, progenies derived from mating between Tet1 knockout males and wild-Peg10 and Peg3, which exhibit aberrant hypermethylation in the paternal allele of differential methylated regions (DMRs).
Imprinting control region (ICR) of the Peg3 domain.
Yu et al., Baton Rouge, United States. In Hum Mol Genet, 2012
Data show that deletion of the Peg3-DMR (Peg3-differentially methylated region) caused global changes in the imprinting and transcription of the Peg3 domain.
Exome sequencing of liver fluke-associated cholangiocarcinoma.
Teh et al., Singapore, Singapore. In Nat Genet, 2012
These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%).
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Mallucci et al., Leicester, United Kingdom. In Nature, 2012
Overexpression of GADD34, a specific eIF2α-P phosphatase, as well as reduction of levels of prion protein by lentivirally mediated RNA interference, reduced eIF2α-P levels.
Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
Pierre et al., Marseille, France. In Proc Natl Acad Sci U S A, 2012
GADD34 was shown to be required for normal cytokine production both in vitro and in vivo.
GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway.
Korhonen et al., Helsinki, Finland. In Exp Cell Res, 2012
results show that GADD34 plays an important role in cell protection in mutant huntingtin expressing cells
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
Pierre et al., Marseille, France. In Plos Pathog, 2011
study demonstrates that GADD34 is absolutely required for type I-IFN and IL-6 production by embryonic fibroblasts in response to dsRNA
PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations.
Marazzi et al., Paris, France. In Proc Natl Acad Sci U S A, 2011
PW1 serves as an invaluable marker for competent self-renewing stem cells in a wide array of adult tissues
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Bertolotti et al., Cambridge, United Kingdom. In Science, 2011
We describe a small molecule, guanabenz, that bound to a regulatory subunit of protein phosphatase 1, PPP1R15A/GADD34, selectively disrupting the stress-induced dephosphorylation of the α subunit of translation initiation factor 2 (eIF2α).
Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development.
Sassoon et al., Paris, France. In Nat Cell Biol, 2010
Here, we identify and describe a population of muscle-resident stem cells, which are located in the interstitium, that express the cell stress mediator PW1 but do not express other markers of muscle stem cells such as Pax7.
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