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PDS5 Pds5p

Pds5, Pds5p, PDS5A, SCC-112
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
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Top mentioned proteins: Scc1, FOE, SMC1, PCNA, CAN
Papers on Pds5
CyclinD1 Down-Regulation and Increased Apoptosis Are Common Features of Cohesinopathies.
Massa et al., Monza, Italy. In J Cell Physiol, Mar 2016
Genetic variants within components of the cohesin complex (NIPBL, SMC1A, SMC3, RAD21, PDS5, ESCO2, HDAC8) are believed to be responsible for a spectrum of human syndromes known as "cohesinopathies" that includes Cornelia de Lange Syndrome (CdLS).
Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation.
Seo et al., Ōsaka, Japan. In J Histochem Cytochem, Jan 2016
Indeed, an immunohistochemical analysis of early-stage ESCC showed that carcinoma cells expressing FGFR3IIIc stained positively with SCC-112, a tumor marker, and Ki67, a cell proliferation marker, suggesting that the expression of FGFR3IIIc promotes cell proliferation.
Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
Hiraoka et al., Kōbe, Japan. In Chromosoma, Nov 2015
These studies revealed that chromosomes are elongated in the absence of the meiotic cohesin subunit Rec8 and shortened in the absence of the cohesin-associated protein Pds5.
Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.
Brakenhoff et al., Amsterdam, Netherlands. In Cancer Res, Oct 2015
Inactivation of FANCM was responsible for chromosomal breakage in one cell line, whereas in two other cell lines, somatic mutations in PDS5A or STAG2 resulted in inadequate sister chromatid cohesion.
Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.
Skibbens et al., Bethlehem, United States. In Proc Natl Acad Sci U S A, Jul 2015
Pds5 is a cohesin-associated factor that is essential for both cohesion maintenance and condensation.
Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.
Mechtler et al., Vienna, Austria. In Mol Cell Proteomics, Mar 2015
We identified known and novel ATM/ATR targets such as LIG4 and MRE11 (needed for resistance against ionizing radiation), PIE1 and SDG26 (implicated in chromatin remodeling), PCNA1, WAPL, and PDS5 (implicated in DNA replication), and ASK1 and HTA10 (involved in meiosis).
Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana.
Santos et al., Madrid, Spain. In Front Plant Sci, 2014
One of these, PDS5, also known as SPO76, is essential during mitosis and meiosis in several organisms and also plays a role in DNA repair.
ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation.
Koshland et al., Berkeley, United States. In Mol Biol Cell, 2014
We provide evidence that ROCC controls cohesion maintenance and condensation establishment through differential functional interactions with Pds5p and Wpl1p.
Pds5 prevents the PolySUMO-dependent separation of sister chromatids.
Lavoie et al., Toronto, Canada. In Curr Biol, 2014
Rather, the cohesin-associated factor Pds5 is also required to keep sisters paired until anaphase onset.
Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.
Losada et al., Madrid, Spain. In Embo J, 2013
There are two Pds5 proteins in vertebrates, Pds5A and Pds5B, but their functional specificity remains unclear.
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.
Yu et al., Dallas, United States. In Nat Cell Biol, 2013
The phospho-SGO1-bound cohesin complex contains PP2A, PDS5 and hypophosphorylated sororin, but lacks WAPL.
Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.
Javerzat et al., Bordeaux, France. In Embo Rep, 2012
Pds5 is essential for cohesin acetylation by Eso1.
HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.
Scheuring et al., Frankfurt am Main, Germany. In Intervirology, 2011
The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication.
The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.
Vince et al., Würzburg, Germany. In Int J Mol Med, 2011
Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
The Mouse Cohesin-Associated Protein PDS5B Is Expressed in Testicular Cells and Is Associated with the Meiotic Chromosome Axes.
Hoog et al., Stockholm, Sweden. In Genes (basel), 2009
The PDS5 protein, an accessory factor of the cohesin complex, is known to be a component of meiotic chromosome cores in fungi and to be implicated in meiotic chromosome structure and function.
Cohesin acetylation speeds the replication fork.
Jallepalli et al., New York City, United States. In Nature, 2009
This defect was a consequence of cohesin's hyperstable interaction with two regulatory cofactors, WAPL and PDS5A (refs 12, 13); removal of either cofactor allowed forks to progress rapidly without ESCO1, ESCO2, or RFC(CTF18).
Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.
Yu et al., Tallahassee, United States. In J Cell Biol, 2009
These data suggest that Pds5 modulates the Rec8 activity to facilitate chromosome morphological changes required for homologue synapsis, DSB repair, and meiotic chromosome segregation.
Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
Milbrandt et al., Saint Louis, United States. In Plos One, 2008
While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.
Fork it over: the cohesion establishment factor Ctf7p and DNA replication.
Eastman et al., Bethlehem, United States. In J Cell Sci, 2007
The recent findings that the establishment factor Ctf7p/Eco1p is recruited to DNA and binds both a DNA polymerase processivity factor (PCNA) and the cohesin regulator Pds5p test current models of sister chromatid pairing.
Spo76p is a conserved chromosome morphogenesis protein that links the mitotic and meiotic programs.
Zickler et al., Orsay, France. In Cell, 1999
Spo76p is conserved and related to the fungal proteins Pds5p and BIMD and the human AS3 prostate proliferative shutoff-associated protein.
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