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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Pyruvate dehydrogenase kinase, isozyme 4

PDK4, pyruvate dehydrogenase kinase, pyruvate dehydrogenase kinase 4
mediates glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC) [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Insulin, CAN, V1a, HAD
Papers using PDK4 antibodies
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Aguila Marcia B., In PLoS ONE, 2000
... Antibodies against tubulin (CAT#ab7291), the beta 3 adrenergic receptor (β3-AR) (CAT#ab94506), PDK4 (CAT#ab38242), and PP2C (CAT# ab27267) were purchased from Abcam (Cambridge, MA) Anti PEPCK ...
Papers on PDK4
miR-211 functions as a metabolic switch in human melanoma cells.
Perera et al., Orlando, United States. In Mol Cell Biol, Feb 2016
HIF-1α protein loss was correlated with the down-regulation of a miR-211 target gene, pyruvate dehydrogenase kinase 4 (PDK4).
Pyruvate Dehydrogenase Kinase-Mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.
Suk et al., United States. In J Biol Chem, Feb 2016
In this study, we report that pyruvate dehydrogenase kinases (PDK2 and PDK4), key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy.
Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis.
Jing et al., Shanghai, China. In Hypertens Res, Feb 2016
The expression of pyruvate dehydrogenase kinase was suppressed, while pyruvate dehydrogenase expression was upregulated with DCA application.
Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3.
Tikoo et al., India. In Mol Cell Endocrinol, Jan 2016
Metabolic memory by palmitate was found to be associated with increased FOXO1 activity as evident from increased expression of FOXO1 target genes such as PDK4, p21, G6Pc and IGFBP1.
Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells.
Jeoung et al., Taegu, South Korea. In Biochem Biophys Res Commun, Jan 2016
In this study, we investigated the effect of lipopolysaccharide (LPS) on the expression of pyruvate dehydrogenase kinase 4 (PDK4), which is strongly associated with inactivation of the PDC in C2C12 myoblasts.
Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents.
Tam et al., Aomen, Macao. In Drug Discov Today, Sep 2015
Many cancer cells demonstrate a high rate of glucose consumption via glycolysis to provide intermediates for macromolecule biosynthesis.
Metabolic modulation of cancer: a new frontier with great translational potential.
Michelakis et al., Edmonton, Canada. In J Mol Med (berl), Feb 2015
A number of molecular tools and small molecules targeting metabolic enzymes, including pyruvate kinase, pyruvate dehydrogenase kinase, isocitrate dehydrogenase, and lactate dehydrogenase, have been developed, inhibiting cancer growth in vitro and in vivo in several cancer types.
Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance.
Siu et al., Hong Kong, Hong Kong. In Cell Physiol Biochem, 2014
Phosphorylation of Foxo1 is thought to mitigate the transactivation of pyruvate dehydrogenase lipoamide kinase 4 (PDK4), which is a negative regulator of the glycolytic enzyme pyruvate dehydrogenase (PDH).
Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.
Kittler et al., Dallas, United States. In Cell Metab, 2014
The antiproliferative effect of PPARγ activation can be prevented by suppressing pyruvate dehydrogenase kinase 4 (PDK4) or β-oxidation of fatty acids in vitro and in vivo.
Clinical impact of the Warburg effect in gastrointestinal cancer (review).
Baba et al., Kumamoto, Japan. In Int J Oncol, 2014
The aim of this review was to discuss significant molecular insights into clinical impacts of the Warburg effect such as oncogenic alterations and overexpression of transcriptional factors (c-Myc and hypoxia-inducible factor), metabolite transporters (glucose transporters) and glycolytic enzymes (hexokinases 2, pyruvate kinase M2, pyruvate dehydrogenase kinase, isozyme 1, lactate dehydrogenase A).
Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate.
Contreras et al., Tijuana, Mexico. In Front Oncol, 2013
Measures which inhibit the constitutive hypoxia-inducible factor-1 (HIF-1) activity in cancers (such as salsalate and mTORC1 inhibitors, or an improvement of tumor oxygenation), or that inhibit the HIF-1-inducible pyruvate dehydrogenase kinase (such as dichloroacetate), can be expected to increase pyruvate oxidation.
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
Peeper et al., Amsterdam, Netherlands. In Nature, 2013
BRAF(V600E)-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2).
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Suda et al., Tokyo, Japan. In Cell Stem Cell, 2013
Here we directly investigated this idea using metabolomic analysis and found that HSCs generate adenosine-5'-triphosphate by anaerobic glycolysis through a pyruvate dehydrogenase kinase (Pdk)-dependent mechanism.
Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding.
Lopaschuk et al., Edmonton, Canada. In Febs Lett, 2012
Data suggest that up-regulation of cardiac PDK4 by high-fat diet (HFD) occurs in conjunction with time-dependent activation of E2F1 transcription factor (E2F1); HFD may initiate early cardiac metabolic alterations through cyclin D1/E2F1/PDK4 axis.
The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle.
Sahlin et al., Stockholm, Sweden. In Acta Physiol (oxf), 2012
mRNA of PGC-1alpha and PDK4 increases markedly in both type I and type II skeletal muscle after either continuous or interval exercise
Acute exercise remodels promoter methylation in human skeletal muscle.
Zierath et al., Stockholm, Sweden. In Cell Metab, 2012
Exercise induced a dose-dependent expression of PGC-1α, PDK4, and PPAR-δ, together with a marked hypomethylation on each respective promoter.
Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome.
Kim et al., Kyŏngju, South Korea. In Diabetes Res Clin Pract, 2012
PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome.
Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction.
Peters et al., Canada. In Appl Physiol Nutr Metab, 2012
PDK4 plays a role in reducing pyruvate dehydrogenase complex activation during low to moderate-intensity muscle stimulation, and that absence of PDK4 and the subsequent changes in carbohydrate utilization may alter force production.
Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4.
Yokoyama et al., Yokohama, Japan. In Acta Crystallogr D Biol Crystallogr, 2011
The present structures demonstrate the flexible and dynamic aspects of PDK4 in the open conformation and provide a basis for the development of novel inhibitors targeting the nucleotide-binding pocket of PDK4.
Population-level transcription cycles derive from stochastic timing of single-cell transcription.
Carlberg et al., Kuopio, Finland. In Cell, 2009
By measuring the cycling expression of the pyruvate dehydrogenase kinase 4 gene in human cells, we constructed a detailed stochastic model for single-gene transcription at the molecular level using realistic kinetics for diffusion and protein complex dynamics.
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