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Platelet derived growth factor D

PDGF-D, Platelet-derived growth factor-D
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PDGF-B, PDGF-C, PDGFR, CAN, V1a
Papers using PDGF-D antibodies
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth
Kim H-R C et al., In Oncogene, 2006
... The quality and concentration of purified recombinant PDGF-D was determined on the basis of silver staining using SilverSNAP staining kit from Thermo Scientific (Rockford, IL, USA) ...
Papers on PDGF-D
The interaction between androgen receptor and PDGF-D in the radiation response of prostate carcinoma.
Kim et al., Detroit, United States. In Prostate, Feb 2016
RESULTS: PTEN loss resulted in upregulation of AR expression in a PDGF-D dependent manner and irradiation selectively increased the nuclear AR protein level and its activity in a murine cell model.
A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
Zhang et al., Shenzhen, China. In Ann Hum Biol, Jan 2016
BACKGROUND: The association between the platelet-derived growth factor D (PDGFD) gene and atherosclerosis has been widely proven, whereas the relationship between the PDGFD gene and ischaemic stroke remains unconfirmed.
Effects of low level laser therapy on inflammatory and angiogenic gene expression during the process of bone healing: A microarray analysis.
Rennó et al., São Carlos, Brazil. In J Photochem Photobiol B, Jan 2016
Microarray analysis demonstrated that LLLT produced an up-regulation of the genes related to the inflammatory process (MMD, PTGIR, PTGS2, Ptger2, IL1, 1IL6, IL8, IL18) and the angiogenic genes (FGF14, FGF2, ANGPT2, ANGPT4 and PDGFD) at 36h and 3days, followed by the decrease of the gene expression on day 7. Immunohistochemical analysis revealed that the subjects that were treated presented a higher expression of COX-2 at 36h after surgery and an increased VEGF expression on days 3 and 7 after surgery.
Clinical significance of platelet derived growth factor-C and -D in gastric cancer.
Sugihara et al., Tokyo, Japan. In Oncol Lett, Dec 2015
UNASSIGNED: Platelet-derived growth factor (PDGF)-C and PDGF-D are frequently upregulated in human cancers and play important roles in tumor progression, angiogenesis and metastasis.
Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients.
Zhang et al., Xi'an, China. In Osteoporos Int, Nov 2015
GWAS meta-analysis identified six candidate genes with pleiotropic effects, including PDGFD, SOX5, DPYD, CTR9, SPP1, and COL4A1.
PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation.
Lu et al., Harbin, China. In Tumour Biol, Sep 2015
However, whether PDGF-D plays a role in these programs remains unclear.
The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells.
Sung et al., Seoul, South Korea. In Histol Histopathol, Jul 2015
In addition, we examined findings pertaining to underlying molecular mechanisms and signaling pathways with special focus on PDGF-D/PDGFRβ.
Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties.
Ferri et al., Milano, Italy. In Vascul Pharmacol, Jul 2015
Homo- and heterodimers of PDGF-A, PDGF-B, PDGF-C and PDGF-D subunits act by binding to homo- or heterodimers of the PDGF tyrosine kinase receptors, PDGFR-α and PDGFR-β.
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.
Oldham et al., San Francisco, United States. In Nature, 2014
By analysing differential gene co-expression relationships between the species, we demonstrate that the growth factor PDGFD is specifically expressed by RG in human, but not mouse, corticogenesis.
Emerging roles of PDGF-D in EMT progression during tumorigenesis.
Wang et al., Bengbu, China. In Cancer Treat Rev, 2013
Platelet-derived growth factor-D (PDGF-D) signaling pathway has been reported to be involved in regulating various cellular processes, such as cell growth, apoptotic cell death, migration, invasion, angiogenesis and metastasis.
Genome-wide studies of gene expression relevant to coronary artery disease.
Smith et al., Cleveland, United States. In Curr Opin Cardiol, 2012
Another recent study detected variants adjacent to a newly identified atherosclerosis risk locus on chromosome 11q22 that were associated with the expression of platelet-derived growth factor D (PDGFD).
Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.
Floege et al., Aachen, Germany. In Kidney Int, 2011
Podocyte-specific PDGF-D overexpression caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis. Podocyte-specific PDGF-D overexpression induced paracrine mesangial cell proliferation upstream of the filtration flow.
A functional variant in promoter region of platelet-derived growth factor-D is probably associated with intracerebral hemorrhage.
Hui et al., Beijing, China. In J Neuroinflammation, 2011
The results of this study suggested that PDGFD -858A/C variant is probably associated with risk for non-hypertensive intracerebral hemorrhage.
PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells.
Nishizaki et al., Nishinomiya, Japan. In Cell Physiol Biochem, 2011
PDGF-D promotes malignant mesothelioma cell chemotaxis through PDGF-betabeta receptor signaling pathways along a PI3 kinase/PDK1/Akt/Rac1/ROCK axis and relevant to ERK activation
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Coronary Artery Disease (C4D) Genetics Consortium, In Nat Genet, 2011
Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11.
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.
Kim et al., Detroit, United States. In Cancer Res, 2011
Study unveiled a novel signaling axis of matriptase/PDGF-D/beta-PDGFR in PCa, providing new insights into functional interplay between serine protease and growth factor signaling networks.
Platelet-derived growth factor-D promotes ovarian cancer invasion by regulating matrix metalloproteinases 2 and 9.
Qiu et al., Wuxi, China. In Asian Pac J Cancer Prev, 2010
High PDGFD expression promotes ovarian cancer invasion by regulating matrix metalloproteinases 2 and 9
Emerging roles of PDGF-D signaling pathway in tumor development and progression.
Sarkar et al., Detroit, United States. In Biochim Biophys Acta, 2010
Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis.
PDGF-D, a new protease-activated growth factor.
Lichenstein et al., New Haven, United States. In Nat Cell Biol, 2001
Recombinant, purified PDGF-D induces DNA synthesis and growth in cells expressing PDGFRs.
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Eriksson et al., Stockholm, Sweden. In Nat Cell Biol, 2001
Here we have identify and characterize a fourth member of the PDGF family, PDGF-D.
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