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Phosphodiesterase 7B

PDE7B, phosphodiesterase 7B
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: Phosphodiesterase, PDE, HAD, CAN, PDE4B
Papers on PDE7B
Phosphodiesterase sequence variants may predispose to prostate cancer.
Faucz et al., Washington, D.C., United States. In Endocr Relat Cancer, Aug 2015
Four novel sequence variations, one each in the PDE4B,PDE6C, PDE7B and PDE10A genes, respectively, were also found in the PCa samples.
Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.
Perez-Castillo et al., Madrid, Spain. In Neurobiol Aging, Feb 2015
In the present study, we have used the toxin 6-hydroxydopamine and lipopolysaccharide to model PD and explore the protective effects of PDE7B deficiency in dopaminergic neurons cell death.
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
Ling et al., Malmö, Sweden. In Plos Genet, 2014
102 of the differentially methylated genes, including CDKN1A, PDE7B, SEPT9 and EXOC3L2, were differentially expressed in T2D islets.
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Kleiman et al., Columbia, United States. In Cell Signal, 2014
In contrast, mRNA expression of PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A did not change with age.
PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2.
Ekström et al., Stockholm, Sweden. In Front Pharmacol, 2013
There is one study indicating that PDE7B may be involved in the activation of testosterone enanthate.
PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.
Rubin et al., Saint Louis, United States. In Plos One, 2013
Using a computational approach, we deconvoluted expression data from a mixed physical co-culture of GBM cells and ECs and identified a previously undescribed upregulation of the cAMP specific phosphodiesterase PDE7B in GBM cells in response to direct contact with ECs.
Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma.
Insel et al., San Diego, United States. In Expert Opin Ther Targets, 2013
EXPERT OPINION: This 'pathway approach' targeted to cAMP has identified GPCR agonists/antagonists, AC activators (e.g., AC7), PDE inhibitors (e.g., PDE7B) and/or activators or inhibitors of downstream mediators (PKA and Epac, respectively), which might be utilized therapeutically in CLL.
New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders.
Abdollahi et al., Tehrān, Iran. In Expert Opin Drug Discov, 2013
EXPERT OPINION: There are only a few selective PDE7 inhibitors that can discriminate between PDE7A and PDE7B, but due to different tissue distribution and physiological functions in the body, the hope is to develop selective PDE7A and PDE7B inhibitors to target more specific functions and pathological conditions without a high likelihood of causing nonspecific side effects.
High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma.
Li et al., Nanjing, China. In Leuk Res, 2013
In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors.
Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy.
Patrinos et al., Pátrai, Greece. In Pharmacogenomics, 2013
AIM: In this study we explored the association between genetic variations in MAP3K5 and PDE7B genes, residing on chromosome 6q23, and disease severity in β-hemoglobinopathy patients, as well as the association between these variants with response to hydroxyurea (HU) treatment.
Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma.
Bertrand et al., Fresnes, France. In Eur Respir J, 2012
For the first time, we have demonstrated that the deletion of the PDE7B gene or the pharmacological inhibition of PDE7A and -B had no effect on all the parameters looked at in this model.
Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia.
Insel et al., San Diego, United States. In Int J Cancer, 2011
High PDE7B is associated with chronic lymphocytic leukemia.
Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease.
Insel et al., San Diego, United States. In J Hum Genet, 2011
The low frequency of this 5' untranslated region variant indicates that it does not explain the higher PDE7B expression in patients with chronic lymphocytic leukemia (CLL) but it has the potential to influence other settings that involve a role for PDE7B.
Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5'-diphospho-glucuronosyltransferase (UGT2B17) gene.
Rane et al., Stockholm, Sweden. In Pharmacogenet Genomics, 2011
Genetic variation in the phosphodiesterase 7B is associated with bioavailability of testosterone enanthate.
[Expression of cyclic nucleotide phosphodiesterase 7B in patients with mantle cell lymphoma and its prognostic significance].
Li et al., Nanjing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
To investigate the expression level of cyclic nucleotide phosphodiesterase (PDE) 7B mRNA and its prognostic value in mantle cell lymphoma (MCL), the real-time quantitative RT-PCR (QPCR) was used to detect pde7b expression levels of bone marrow mononuclear cells from 20 newly diagnosed MCL patients with bone marrow involvement and peripheral blood mononuclear cells from 20 normal persons, the association of pde7b expression levels with prognostic indexes was analyzed by statistical software.
A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1.
Tommerup et al., Copenhagen, Denmark. In Behav Genet, 2011
As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.
Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity.
Degerman et al., Lund, Sweden. In Nutr Diabetes, 2010
In addition to PDE3 and 4 isoforms, PDE7B, PDE9A and PDE10A proteins were also detected in adipose tissue or adipocytes.
Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
Mengod et al., Barcelona, Spain. In Brain Res, 2010
All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
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