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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphodiesterase 2A, cGMP-stimulated

PDE2A, cGMP-stimulated phosphodiesterase, phosphodiesterase 2A
Top mentioned proteins: Phosphodiesterase, PDE, HAD, CAN, V1a
Papers on PDE2A
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus.
Kroker et al., Biberach an der Riß, Germany. In Synapse, Oct 2015
Inhibitors of PDE2A and PDE9A have emerged as potential candidates shown to improve synaptic plasticity and memory function in animals.
Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer.
Takai et al., Tokyo, Japan. In Cancer Med, Oct 2015
MiR-139 is located within the intron of PDE2A and its expression was significantly correlated with the expression of PDE2A.
Calcium-dependent mitochondrial cAMP production enhances aldosterone secretion.
Spät et al., Budapest, Hungary. In Mol Cell Endocrinol, Oct 2015
The effect of angiotensin II is inhibited by 2-OHE, an inhibitor of sAC, and by RNA interference of sAC, but enhanced by an inhibitor of phosphodiesterase PDE2A.
Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A.
Jørgensen et al., Copenhagen, Denmark. In Eur J Pharmacol, Sep 2015
Here, we present a preliminary pharmacological characterisation of Lu AF33241, a novel, brain penetrant phosphodiesterase inhibitor of (PDE) 2A and 10A tool compound, in in vitro/in vivo assays indicative of PDE2A and/or PDE10A inhibition, and in vivo models/assays relevant to cognitive processing and antipsychotic-like activity.
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Wu et al., Stanford, United States. In Cell Stem Cell, Aug 2015
Although expression levels of several β-adrenergic signaling components were unaltered between control and DCM iPSC-CMs, we found that phosphodiesterases (PDEs) 2A and PDE3A were upregulated in DCM iPSC-CMs and that PDE2A was also upregulated in DCM patient tissue.
Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.
Paterson et al., Oxford, United Kingdom. In Hypertension, Jul 2015
In addition, overexpression of phosphodiesterase 2A after adenoviral gene transfer markedly decreased BNP stimulation of cGMP and abrogated the BNP responses to the calcium current, intracellular calcium transient, and neurotransmitter release.
Gene-Gene Associations with the Susceptibility of Kawasaki Disease and Coronary Artery Lesions.
Yang et al., Kao-hsiung, Taiwan. In Plos One, 2014
In logistic regression, combined possession of PDE2A (rs341058) and CYFIP2 (rs767007) significantly increased KD susceptibility (OR = 3.54; p = 4.14 x 10-7), while combinations of LOC100133214 (rs2517892) and IL2RA (rs3118470) significantly increased the risk of CAL in KD patients (OR = 5.35; p = 7.46 x 10-5).
Whole-genome cartography of p53 response elements ranked on transactivation potential.
Inga et al., Trento, Italy. In Bmc Genomics, 2014
Based on the mapping of predicted functional REs near TSS, we examined expression changes of thirteen genes as a function of different p53-inducing conditions, providing further evidence for PDE2A, GAS6, E2F7, APOBEC3H, KCTD1, TRIM32, DICER, HRAS, KITLG and TGFA p53-dependent regulation, while MAP2K3, DNAJA1 and potentially YAP1 were identified as new direct p53 target genes.
Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography.
Brust et al., Leipzig, Germany. In Molecules, 2014
Phosphodiesterase 2A (PDE2A) is highly and specifically expressed in particular brain regions that are affected by neurological disorders and in certain tumors.
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Yamamoto et al., Yokohama, Japan. In Nat Genet, 2012
Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
Steegborn et al., New York City, United States. In J Biol Chem, 2011
the phosphodiesterase 2A isoform localized to mitochondria regulates respiration
Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5).
Hedlund et al., Hannover, Germany. In Int J Impot Res, 2011
found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space
Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design.
Manallack et al., Australia. In J Comput Aided Mol Des, 2011
Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.
Klevit et al., Seattle, United States. In Structure, 2010
NMR data and details from the structure of full-length nucleotide-free PDE2A reveal the dynamic nature and magnitude of the conformational change that accompanies nucleotide binding.
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
Menniti et al., United States. In Proc Natl Acad Sci U S A, 2009
report the X-ray crystal structures of a PDE protein that includes both catalytic and regulatory domains, namely, PDE2A containing the N-terminal GAF domains and the catalytic domain.
Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.
Russwurm et al., Bochum, Germany. In J Biol Chem, 2009
dual acylation as mechanism targeting neuronal PDE2A3 to synapses thereby ensuring local control of cyclic nucleotides.
Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling.
Smolenski et al., Florianópolis, Brazil. In Biochem Pharmacol, 2009
Furthermore, XAP2 binds the cyclic nucleotide phosphodiesterases PDE2A and PDE4A5.
Sodium regulation of GAF domain function.
Cann, Durham, United Kingdom. In Biochem Soc Trans, 2007
Sodium inhibits the activity of CyaB1, CyaB2 and mammalian PDE2A in vitro through modulation of GAF domain function.
Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels.
Vandecasteele et al., Châtenay-Malabry, France. In Comp Biochem Physiol A Mol Integr Physiol, 2005
Some of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the cGMP-inhibited PDE (PDE3).
Platelet cyclic adenosine monophosphate phosphodiesterases: targets for regulating platelet-related thrombosis.
Colman, Philadelphia, United States. In Semin Thromb Hemost, 2004
In contrast, PDE2A hydrolyzes both cAMP and cGMP with a high K (m), is allosterically stimulated by cGMP at moderate levels, and may control the stimulated levels of cAMP.
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