GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Programmed cell death 1 ligand 2
PD-L2, B7-DC
Top mentioned proteins:
PD-L1, CAN, H1, CD4, CD80
Papers using
PD-L2
antibodies
Cross-linking the B7 Family Molecule B7-DC Directly Activates Immune Functions of Dendritic Cells
Supplier
In The Journal of Experimental Medicine, 2000
... TY-25 anti–B7-DC antibody is available from eBioscience.
Papers on
PD-L2
Tolerogenic Effect of Mouse Fibroblasts on Dendritic Cells.
New
Vancouver, Canada. In Immunology, Feb 2016
The results of our in vitro study showed that both co-inhibitory (PD-L1, PD-L2 and B7H4) and co-stimulatory (CD86) molecules were up-regulated when DCs were co-cultured with fibroblasts.
EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features.
New
Leuven, Belgium. In Am J Transplant, Feb 2016
The most prevalent aberration in EBV(+) PT-DLBCL was gain/amplification of 9p24.1 targeting PDCD1LG2/PDL2.
Programmed Death Ligand 1 Immunohistochemistry- A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society.
New
Nagoya, Japan. In Arch Pathol Lab Med, Feb 2016
UNASSIGNED: The binding of programmed death ligands 1 and 2 (PD-L1 and PD-L2) to PD-1 blocks T-cell-mediated immune response to tumor.
Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders.
New
Boston, United States. In Am J Surg Pathol, Feb 2016
UNASSIGNED: Programmed cell death 1 ligands 1 and 2 (PD-L1 and PD-L2) are cell surface proteins expressed by activated antigen-presenting cells and by select malignancies that bind PD-1 on T cells to inhibit immune responses.
Presentation of high Ag-dose by splenic B220(lo) B cells fosters a feedback loop between Th2 memory and antibody isotype switching.
New
Columbia, United States. In Immunology, Feb 2016
Moreover, among the B cell subsets tested for induction of Th2 memory, the splenic but not peritoneal B220(lo) cells were most effective in sustaining Th2 memory development as well as Ig isotype switching, and this function involved a tight control by PD1-PD-L2 interactions.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.
Review
New
Houston, United States. In Biochim Biophys Acta, Nov 2015
PD-1 and its ligands, PD-L1 and PD-L2, are overexpressed by various types of tumors as well as reactive cells in the tumor microenvironment.
Antagonists of PD-1 and PD-L1 in Cancer Treatment.
Review
New
Baltimore, United States. In Semin Oncol, Aug 2015
The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment.
Stimulating immune responses to fight cancer: Basic biology and mechanisms.
Review
New
Brisbane, Australia. In Asia Pac J Clin Oncol, Apr 2015
The current focus of these trials is on the programmed cell death protein 1 (PD-1) receptor and its ligands (PD-L1, PD-L2) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.
New
Impact
Mainz, Germany. In Nat Immunol, Mar 2015
Genetic ablation of the β-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3(+) Treg cell subpopulation that was unable to control the maturation of IRF4(+)PD-L2(+) dendritic cells required for the development of TH2 responses in vivo.
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.
New
Impact
Mongolia. In N Engl J Med, Feb 2015
Study objectives were measurement of safety and efficacy and assessment of the PDL1 and PDL2 (also called CD274 and PDCD1LG2, respectively) loci and PD-L1 and PD-L2 protein expression.
Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations.
Review
Tokyo, Japan. In Pathobiology, 2014
In addition to having the highest level of DNA methylation in CpG islands of promoter regions, EBVaGC harbors particular gene alterations, including a high frequency of mutations in PIK3CA and ARID1A, mutation in BCOR, and amplification of PD-L1 and PD-L2.
Human Cancer Immunotherapy with PD-1/PD-L1 Blockade.
Review
Changsha, China. In Biomark Cancer, 2014
The ligation of programmed cell death-1 (PD-1) to its ligands PD-L1 and PD-L2 counteracts T-cell activation, which is critical in immune tolerance.
Comprehensive molecular characterization of gastric adenocarcinoma.
Impact
In Nature, 2014
We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases.
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.
Impact
New Haven, United States. In Nat Immunol, 2014
Here we demonstrate that subcategorizing MBCs on the basis of their expression of CD80 and PD-L2, independently of isotype, identified MBC subsets with distinct functions upon rechallenge.
Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression.
GeneRIF
United States. In Clin Cancer Res, 2012
Data show that PD-1, PD-L1, PD-L2, CCL17, and CCL22 mRNA was identified in papillomas.
OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease.
GeneRIF
London, United Kingdom. In J Immunol, 2012
OX40L and PD-L2 expressed on dendritic cells differentially regulate cytokine production during recall responses in the lung.
Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis.
GeneRIF
T'ai-chung-shih, Taiwan. In Rheumatology (oxford), 2011
Our results suggest that PD-1 G-536A, PD-L1 A8923C and PD-L2 C47103T polymorphisms are associated with the presence of ankylosing spondylitis.
Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.
GeneRIF
Wuhan, China. In World J Gastroenterol, 2011
Data suggest that PD-L1 may contribute to negative regulation of the immune response in chronic hepatitis B, and that PD-1 and PD-L1 and 2 may play a role in immune evasion of tumors.
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.
Impact
Vancouver, Canada. In Nature, 2011
As functional consequences of CIITA gene fusions, we identify downregulation of surface HLA class II expression and overexpression of ligands of the receptor molecule programmed cell death 1 (CD274/PDL1 and CD273/PDL2).
Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis.
GeneRIF
Montréal, Canada. In J Neuroinflammation, 2010
Data suggest that brain endothelial cells contribute to control T cell transmigration into the CNS and immune responses via PD-L2 but not PD-L1 expression.
