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Protocadherin gamma subfamily A, 1

PCDHGA, Pcdh-gammaA
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, Protocadherins, CAN, Pcdh-alpha, p64
Papers on PCDHGA
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer.
Houlston et al., Edinburgh, United Kingdom. In Sci Rep, 2014
Gene based tests identified associations between CRC and PCDHGA genes (P < 2.90 × 10(-6)).
LC3-dependent intracellular membrane tubules induced by gamma-protocadherins A3 and B2: a role for intraluminal interactions.
Phillips et al., New York City, United States. In J Biol Chem, 2010
These results suggest that Pcdh-gammaA and -gammaB families can influence the shape of intracellular membranes by mediating intraluminal interactions within organelles.
Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells.
Yagi et al., Suita, Japan. In J Biol Chem, 2006
Here we investigated total allelic gene regulation in the Pcdh-alpha and -gamma clusters, including the C-type variable exons (C1 to C5) and the Pcdh-gammaA and -gammaB variable exons in single Purkinje cells.
Differential expression of individual gamma-protocadherins during mouse brain development.
Kemler et al., Freiburg, Germany. In Mol Cell Neurosci, 2005
Several individual members of the in total 22 Pcdhs-gamma were chosen to examine the expression of the three subfamilies, Pcdh-gammaA, -gammaB, and -gammaC.
Variation in the protocadherin gamma A gene cluster.
Owen et al., Cardiff, United Kingdom. In Genomics, 2003
We screened for variation in the 12 protocadherin gamma A (PCDHGA) genes of the protocadherin cluster on chromosome 5q31.
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