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Protocadherin beta 1

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, Pcdh-alpha, Protocadherins, CIs, Alpha-1
Papers on Pcdh-beta
Proteomics analysis reveals overlapping functions of clustered protocadherins.
Wang et al., Evanston, United States. In Mol Cell Proteomics, 2010
The three tandem-arrayed protocadherin (Pcdh) gene clusters, namely Pcdh-alpha, Pcdh-beta, and Pcdh-gamma, play important roles in the development of the vertebrate central nervous system.
Clustered protocadherin family.
Yagi, Suita, Japan. In Dev Growth Differ, 2008
In mammals, the clustered Pcdh family consists of three gene clusters: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma.
The role and expression of the protocadherin-alpha clusters in the CNS.
Yagi et al., Suita, Japan. In Curr Opin Neurobiol, 2006
The family of clustered protocadherins (clustered Pcdh family) is substructured into three distinct gene arrays in mammals: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma.
Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and -beta gene clusters.
Yagi et al., Suita, Japan. In Gene, 2005
Among coding SNPs (cSNPs), nonsynonymous (amino acid exchange) SNPs were 2.2 times more common than synonymous (silent) changes in the Pcdh-alpha variable exons, but only 1.2 times more common in the Pcdh-beta variable exons.
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.
Maniatis et al., Cambridge, United States. In Genome Res, 2001
The genomic organization of the human protocadherin alpha, beta, and gamma gene clusters (designated Pcdh alpha [gene symbol PCDHA], Pcdh beta [PCDHB], and Pcdh gamma [PCDHG]) is remarkably similar to that of immunoglobulin and T-cell receptor genes.
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